AFRICA Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 28 Figure 1.3: Changes in weekly A) food intake and B) normalized food intake in female SHR. Food intake was measured weekly from the week of surgery (Sx) and continuing through the 10-week intervention period (week 0 to 10). The dotted line at week 0 separates the preintervention period (baseline) from the 10-week CPS intervention period. Both food intake and normalized food intake significantly decreased in all groups overtime. Ovariectomized groups had an increased food intake compared to sham-operated groups. However, when normalized to body mass, ovariectomized groups had decreased food intake compared to sham-operated groups. Data expressed as mean ± SD, n=9 per group. Ctr Light, control lighting; CPS, chronic phase shift; Ovx, ovariectomy, Sx, pre-surgery food intake. ###, p<0.0001 change overtime; *, p<0.05 vs sham-operated groups; ***, p<0.0001 vs shamoperated groups. Figure 1.4: Changes in weekly A) water intake and B) normalized water intake in female SHR. Water intake was measured weekly from the week of surgery (Sx) and continuing through the 10-week intervention period (week 0 to 10). The dotted line at week 0 separates the pre-intervention period (baseline) from the 10-week CPS intervention period. Both water intake and normalized water intake significantly decreased in all groups overtime. Water intake was increased in ovariectomized groups 3 weeks following surgery, and from week 4 of CPS intervention the water intake was increased in the CPS groups compared to the control light groups. However, when normalized to body mass, ovariectomized groups has decreased water intake compared to sham-operated groups. Data expressed as mean ± SD, n=9 per group. Ctr Light, control lighting; CPS, chronic phase shift; Ovx, ovariectomy, Sx, pre-surgery water intake. ##, p<0.01 and ###, p<0.0001 change overtime; †, p<0.05 vs CPS groups; *, p<0.05 vs sham-operated groups Figure 1.5: Changes in weekly A) systolic and B) diastolic blood pressure (BP) in female SHR during the 10-week CPS intervention. The BP was measured noninvasively using a NIBP250 monitor system. The systolic BP and diastolic BP remained similar across all groups, with no significant effect of CPS or estrogen deficiency. Data expressed as mean ± SD, n=9 per group. Ctr Light, control lighting; CPS, chronic phase shift; Ovx, ovariectomy; BP, blood pressure. Figure 1.6: Changes in A) weekly fasting blood glucose concentrations and B) 3-hour oral glucose tolerance test (OGTT) results in female SHR. The fasting blood glucose concentrations were measured weekly during the 10-week CPS intervention. The 3-hour OGTT was performed 3 days before the end of the 10-week CPS intervention. No significant differences were observed in fasting blood glucose or glucose tolerance between all the groups. Data expressed as mean ± SD, n=9 per group. Ctr Light, control lighting; CPS, chronic phase shift; Ovx, ovariectomy. Submission ID: 1638 continued POSTER PRESENTATION
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