Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 7 AFRICA ORAL PRESENTATION Submission ID: 1619 Introduction Depressed baroreceptor sensitivity (BRS) is evident in hypertension, reported as a critical contributor to cardiovascular disease (CVD) risk in adults. Moreover, poor CVD outcomes are imminent pertaining to chronic kidney disease and heart failure. However, if the same associations can be discerned in younger cohorts are unknown. Our study therefore aimed to determine if BRS relates to kidney function and family history (FH) of CVD and lifestyle risk factors in prepubescent boys stratified by blood pressure status. Methods Our study included 40 black and 41 white boys (aged 6 – 8 years) from North-West, South Africa. Anthropometric and basic demographic data were collected (including information on FH. Cardiovascular measures included blood pressure (BP) and beat-to-beat Finometer measurement for BRS calculation. Urine samples were analysed to determine the albumin-to-creatinine ratio (ACR), indicative of kidney function. For statistical analysis, stratification was based on BP status of normal or elevated. Results The elevated BP group (n=37; 46%) had more Black boys (p=0.003). BRS (p=0.56) and ACR (p=0.92) were comparable between the normal and elevated BP groups. Within the normal BP group, BRS correlated with ACR in single (r=-0.43; p=0.006) and partial (r=-0.41; p=0.01) regression analysis after adjusting for ethnicity, age, and waist circumference. This association was confirmed in backward multiple linear regression analysis (β=-0.38; p=0.009) adjusting for age, ethnicity, waist circumference and mean arterial pressure. In the elevated BP group, BRS associated with FH in single (r=-0.39; p=0.02), partial (r=-0.55; p=0.001) and backward multiple linear regression analysis (β=-0.54; p=0.001). No association between BRS and ACR was evident in the elevated BP group. Conclusion We observed a cardioprotective relationship between BRS and kidney function in boys with normal blood pressure. Whereas, in boys with elevated blood pressure, their predisposed FH related cardiovascular risk may be amplified by lower BRS. Name: Presenting Author Information Article Category Abstract Title Hypertension in Africa Research Team, MRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom lisa.uys@nwu.ac.za English Abstract Researchers/Clinicians - Early, mid & senior career Baroreceptor sensitivity, kidney function and positive family history of cardiovascular and lifestyle risk in boys with normal and elevated blood pressure Author Affiliation: Email: Dr Lisa Uys Science Theme Population Authors Name & Surname Title Expertise Affiliation Email Country Lisa Uys Dr Cardiovascular Physiology Hypertension in Africa Research Team, MRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom lisa.uys@nwu.ac.za South Africa Wayne Smith Prof Cardiovascular Physiology Hypertension in Africa Research Team, MRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom wayne.smith@nwu.ac.za South Africa Carina Mels Prof Cardiovascular Physiology & Biochemistry Hypertension in Africa Research Team, MRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom carina.mels@nwu.ac.za South Africa Annemarie Wentzel Dr Cardiovascular Physiology Hypertension in Africa Research Team, MRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom annemarie.wentzel@nwu.ac.za South Africa
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