AFRICA Cardiovascular Journal of Africa • SAHS Biennial Congress 2024 8 Submission ID: 1622 Introduction Nocturnal blood pressure is a predictor of cardiovascular disease irrespective of daytime blood pressure. The magnitude of nocturnal blood pressure can be altered by various factors including sleep duration. Sleep dysregulation (short and long sleep duration) may be evident in individuals with depressive symptoms and is associated with increased nocturnal blood pressure, however, data in young populations are scant. The aim of this study was to investigate whether associations exist between nocturnal blood pressure and sleep duration in young adults with and without depressive symptoms. Methods We included apparently healthy individuals with (N=257) and without (N=531) depressive symptoms aged 20-30 years. Participants were normotensive at screening (clinic blood pressure <140/90 mmHg). We determined nocturnal blood pressure from 24-hour ambulatory blood pressure monitoring while sleep duration was assessed using diary cards and Acti-heart data. Stratification of individuals with and without depressive symptoms were based on the assessment of depression severity with the 9-item Patient Health Questionnaire (none-to-minimal symptoms and moderate-to-severe symptoms, respectively). Results Sleep duration was higher in individuals with depressive symptoms compared to those without depressive symptoms (p=0.004). After multiple adjustments for covariates, an independent negative association (Adjusted R-squared=0.109; β=-0.19; p=0.002) was observed between nocturnal diastolic blood pressure and sleep duration in individuals with depressive symptoms only. Conclusion The negative association between nocturnal diastolic blood pressure and sleep duration may indicate that longer sleep duration may be play a protective role against the elevated nocturnal blood pressure in individuals with depressive symptoms. Name: Presenting Author Information Article Category Abstract Title North-West University Gontse.Mokwatsi@nwu.ac.za English Abstract Researchers/Clinicians - Early, mid & senior career Association between nocturnal blood pressure and sleep duration in individuals with and without depressive symptoms Author Affiliation: Email: Gontse Mokwatsi Science Theme Basic Author Name & Surname Title Expertise Affiliation Email Country Gontse Mokwatsi Dr Hypertension and blood pressure monitoring North-West University Gontse.Mokwatsi@nwu.ac.za South Africa ORAL PRESENTATION
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