CARDIOVASCULAR JOURNAL OF AFRICA • Volume 35, No 3, September – October 2024 AFRICA 171 zation: retrospective study of tolerance, radiation and recurrence rate. Quant Imaging Med Surg 2015; 5(6): 806–814. 25. Karahan O, Balkan M, Hafız E, Khalil E. Investigation of biological effects of n-butyl 2 cyanoacrylate. Aegean J Med Sci 2020; 1: 20–31. [Article in Turkish] 26. Jones AD, Boyle EM, Woltjer R, Jundt JP, Williams AN. Persistent type IV hypersensitivity after cyanoacrylate closure of the great saphenous vein. J Vasc Surg Cases Innov Tech 2019; 5(3): 372–374. 27. Sermsathanasawadi N, Hanaroonsomboon P, Pruekprasert K, Prapassaro T, Puangpunngam N, Hongku K, et al. Hypersensitivity reaction after cyanoacrylate closure of incompetent saphenous veins in patients with chronic venous disease: A retrospective study. J Vasc Surg Venous Lymphat Disord 2021; 9(4): 910–915. 28. Aballay AM, Recio P, Slater H, Goldfarb IW, Tolchin E, Papasavas P, et al. The use of esmarch exsanguination for the treatment of extremity wound burns. Ann Burns Fire Disasters 2007; 20(1): 22–24. 29. Grebing BR, Coughlin MJ. Evaluation of the Esmarch bandage as a tourniquet for forefoot surgery. Foot Ankle Int 2004; 25(6): 397–405. 30. De Maeseneer MG, Kakkos SK, Aherne T, Baekgaard N, Black S, Blomgren L, et al., Editor’s Choice – European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. Eur J Vasc Endovasc Surg 2022; 63(2): 184–267. Erratum in: Eur J Vasc Endovasc Surg 2022; 64(2–3): 284–285. Experts challenge ‘one-size-fits-all’ aspirin guidelines Heart disease researchers have identified a group of patients in whom, they suggest, international guidelines on aspirin use for heart health may not apply. In a research letter published in Circulation, the findings of a review of data from three clinical trials challenges current best practice for use of the drug for primary prevention of heart disease or stroke (atherosclerotic cardiovascular disease). The research examined the results from clinical trials involving more than 47 000 patients in 10 countries, including the US, the UK and Australia, which were published in 2018. The analysis focused on findings for a subgroup of 7 222 patients who were already taking aspirin before the three trials started. Those studied were at increased risk of cardiovascular disease and were taking aspirin to prevent the first occurrence of a heart attack or stroke. The data showed a higher risk of heart disease or stroke: 12.5 versus 10.4% for patients on aspirin before the trials and who then stopped, compared with those who stayed on the drug. Analyses also found no significant statistical difference in the risk for major bleeding between the two groups of patients. The research was led by Professor J William McEvoy, Established Professor of Preventive Cardiology at University of Galway and Consultant Cardiologist at Saolta University Health Care Group, in collaboration with researchers from the University of Tasmania and Monash University, Melbourne. McEvoy said they had ‘challenged the notion that aspirin discontinuation is a one-size-fits-all approach’ and had noted results from observational studies, suggesting a 28% higher risk of heart disease or stroke among adults prescribed aspirin to reduce the risk for a first heart attack or stroke, but who subsequently chose to stop taking the aspirin without being told to do so by their doctor. Based in large part on three major clinical trials published in 2018, international guidelines no longer recommend the routine use of aspirin to prevent the first occurrence of heart attack or stroke. Importantly, aspirin remains recommended for high-risk adults who have already had a heart disease or stroke event, to reduce the risk of a second event. The move away from primary prevention aspirin in recent guidelines is motivated by the increased risk of major bleeding seen with this common medication in the three trials, albeit major bleeding is relatively uncommon on aspirin and was most obvious only among trial participants who were started on aspirin during the trial, rather than those who were previously taking aspirin safely. These trials primarily tested the effect of starting aspirin among adults who had not previously been treated with the drug to reduce the risk of atherosclerotic cardiovascular disease. Less is known about what to do in the common scenario of adults who are already safely taking aspirin for primary prevention. McEvoy said: ‘Our findings of the benefit of aspirin in reducing heart disease or stroke without an excess risk of bleeding in some patients could be because adults already taking aspirin without a prior bleeding problem are inherently lower risk for a future bleeding problem from the medication. Therefore, they seem to get more of the benefits of aspirin with fewer risks. ‘These results are hypothesis-generating, but at present are the best available data. Until further evidence becomes available, it seems reasonable that people already safely treated with low-dose aspirin for primary prevention may continue to do so, unless new risk factors for aspirin-related bleeding develop.’ Source: MedicalBrief 2024
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