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CARDIOVASCULAR JOURNAL OF AFRICA • Vol 24, No 2, March 2013

AFRICA

e3

In these two cases, the occurrence of both ST-segment and

T-wave alternans in the right precordial leads was observed

during the recovery phase from febrile states, rather than at peak

hyperthermia, without associated ventricular arrhythmias. In this

regard, the cellular mechanism of ST–T-wave alternans may be

related to incomplete recovery of the ionic current balance, and

these kinds of alternans in Brugada electrocardiogram may be

regarded as normal during the recovery phase from febrile states.

Electrophysiology may be useful for the diagnosis of Brugada

syndrome and risk stratification of individuals with a Brugada

electrocardiogram. This was not done in these two cases.

References

1.

Porres JM, Brugada J, Urbistondo V, García F, Reviejo K, Marco P

Fever unmasking the Brugada syndrome.

Pacing Clin Electrophysiol

2002;

25

: 1646–1648.

2.

Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R,

Corrado D,

et al.

Brugada syndrome: report of the second consensus

conference.

Heart Rhythm

2005;

2

: 429–440, erratum on 905.

3.

Keller DI, Rougier JS, Kucera JP, Benammar N, Fressart V, Guicheney

P,

et al

. Brugada syndrome and fever: genetic and molecular characteri-

zation of patients carrying SCN5A mutations.

Cardiovasc Res

2005;

67

: 510–519.

4.

Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A,

et al

. Induced Brugada-type electrocardiogram, a sign for imminent

malignant arrhyth­mias.

Circulation

2008;

117

: 1890–1893.

5.

Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko DV, Nesterenko

VV,

et al

. Ionic mechanisms responsible for the electrocardiographic

phenotype of the Brugada syndrome are temperature dependent.

Circ

Res

1999;

85

: 803–809.

6.

Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Spontaneous

T wave alternans in a patient with Brugada syndrome – responses

to intravenous administration of class I antiarrhythmic drug, glucose

tolerance test, and atrial pacing.

J Cardiovasc Electrophysiol

2005;

16

:

217–220.

7.

Tada T, Kusano KF, Nagase S, Banba K, Miura D, Nishii N,

et al

.

Clinical significance of macroscopic T-wave alternans after sodium

channel blocker administration in patients with Brugada syndrome.

J

Cardiovasc Electrophysiol

2008;

19

: 56–61.

8.

Fish JM, Antzelevitch C. Cellular mechanism and arrhythmogenic

potential of T-wave alternans in the Brugada syndrome.

J Cardiovasc

Electrophysiol

2008;

19

: 301–308.

9.

Morita H, Nagase S, Kusano K, Ohe T. Spontaneous T wave alter-

nans and premature ventricular contractions during febrile illness in

a patient with Brugada syndrome.

J Cardiovasc Electrophysiol

2002;

13

: 816–818.

10. Ortega-Carnicer J, Benezet J, Ceres F. Fever-induced ST-segment

elevation and T-wave alternans in a patient with Brugada syndrome.

Resuscitation

2003;

57

: 315–317.