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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 29, No 4, July/August 2018

AFRICA

261

FFR/iFR (fractional flow reserve/instantaneous free-wave

ratio) helps to identify haemodynamically significant disease

in non-culprit vessels.

Many patients in the developing world live far away from

cities and the need for urgent repeat revascularisation may

translate into a mortality difference due to treatment delay.

Saving costs initially via the IRA-only approach could incur

higher costs at a later stage and this is particularly relevant in

the African setting since most patients are liable for ‘out-of

pocket’ expenses.

The counter argument that the initial strategy should be primary

percutaneous coronary intervention (PPCI) of the IRA-only was

made by Dr Suliman who presented the evidence cited below:

All studies did not demonstrate a mortality benefit and event

rates were primarily driven by the need for repeat revascu-

larisation.

All studies cited above performed complete revascularisation

on the IRA-only without any attempt to risk-stratify the

haemodynamic significance of the lesions in the non-IRA

vessels using non-invasive testing. The Prague 13 trial, which

excluded patients with angina more than a month before

STEMI, was equivocal.

Patients with left main stem or proximal significant disease in

the N-IRA should undergo full revascularisation with PCI or

coronary artery bypass grafting (CABG).

FFR is not available in most cardiac catheterisation laborato-

ries on the African continent.

On average, one to two extra stents were used in patients

undergoing complete revascularisation and extra contrast

was used, adding a significant financial burden. Such valuable

resources can be shifted to perform more primary angioplasty

procedures for STEMI patients.

Dr Suliman concluded by advocating a strategy of culprit-

artery only and non-invasive ischaemia-testing for limited-resource

settings. At the end of the debate, the audience was almost evenly

split when polled regarding the two approaches. Results of

ongoing trials are eagerly awaited to shed more light on the subject

References

1.

Ibanez B, James S, Agewall S,

et al

. 2017 ESC Guidelines for the

management of acute myocardial infarction in patients presenting

with ST-segment elevation: the task force for the management of acute

myocardial infarction in patients presenting with ST-segment elevation

of the European Society of Cardiology (ESC).

Eur Heart J

2018;

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(2):

119–177.

2.

Wald DS, Morris JK, Wald NJ,

et al.

Randomized trial of preventa-

tive angioplasty in myocardial infarction.

N Engl J Med

2013;

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(12):

1115–1123.

3.

Gershlick, AH, Khan, JN, Kelly DJ,

et al

. Randomized trial of complete

versus lesion-only revascularization in patients undergoing primary

percutaneous coronary intervention for STEMI and multivessel disease:

the CvLPRIT trial.

J Am Coll Cardiol

2015;

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(10): 963–972.

4.

Engstrøm T, Kelbæk H, Helqvist S,

et al

. Complete revascularisation

versus treatment of the culprit lesion only in patients with ST-segment

elevation myocardial infarction and multivessel disease (DANAMI-3—

PRIMULTI): an open-label, randomised controlled trial.

Lancet

2015;

386

(9994): 665–671.

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Smits PC, Abdel-Wahab M, Neumann FJ,

et al.

Fractional flow reserve-

guided multivessel angioplasty in myocardial infarction.

N Engl J Med

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Hlinomaz O, Groch L, Poloková K,

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South Africa–Cuba medical training programme: flawed but successful

After more than 20 years, the contentious South Africa–

Cuba medical training programme is being downscaled.

Business Day’

s Tamar Kahn assessed the situation as the

largest-ever cohort of 720 students prepares to return to

embark on local clinical training.

More than 20 years ago, Desmond Kegakilwe left

Tlakgameng village in rural North West to study medicine in

Cuba. According to a

Business Day

report, back then there

were few local doctors serving in his community and little

hope for young people from underprivileged backgrounds

who aspired to a medical career. Today he is the acting

clinical manager at Ganyesa District Hospital near Vryburg,

and five of the eight doctors employed at the rural facility are

Cuban-trained South Africans.

‘Obviously it was not an easy route, but rural areas now

have permanent South African doctors who can speak the

language of their patients. Some of us would never have

had the opportunity to study medicine in South Africa,’

Kegakilwe says.

The report says South Africa began sending aspirant

doctors to train in Cuba in 1997 under a deal that also saw

Cuba send its doctors to work in South Africa’s rural areas.

The South Africans joined students from all over the world

taking advantage of the many medical schools created under

Fidel Castro’s watch to provide personnel for his country’s

free universal healthcare system.

South Africa recruited bright young people from

underprivileged backgrounds and sent them to Cuba on

bursaries that required them to work for an equal number

of years in the state sector after they had qualified. But,

the report says, the programme was contentious from the

beginning, as the ANC-led government maintained close

political ties to Castro, in recognition of his support for the

organisation when it was in exile during apartheid.

continued on page 264…