AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 46 Submission ID: 1606 THIS STUDY AIMS TO EVALUATE THE PROGNOSTIC VALUE OF HEART RATE VARIABILITY (HRV) STUDY FOR DEATH AND NYHA CLASS IMPROVEMENT IN PATIENTS WITH SYMPTOMATIC ADVANCED HEART FAILURE UNDERGOING CARDIAC RESYNCHRONIZATION THERAPY (CRT) SANA HAMDI, ABDEDDAYEM HAGGUI, WAFA FEHRI TUNISIA Objectives: This study aims to evaluate the prognostic value of heart rate variability (HRV) study for death and NYHA class improvement in patients with symptomatic advanced heart failure undergoing cardiac resynchronization therapy (CRT). Background: Data on the prognostic value of HRV in patients treated with CRT are scarce. To our knowledge, the present study is the first to describe the relationship between the baseline HRV values and the response to CRT in an African population. Methods: We analyzed the relationship between pre-implant time-domain HRV parameters (SDANN: Standard Deviation of the Averages of NN intervals in all 5 min segments of the entire recording, SDNN: Standard Deviation of all NN intervals, rMSSD: the squared root of the mean of the sum of the squares of differences between adjacent NN intervals, pNN50: number of adjacent NN intervals differing by more than 50 ms divided by the total number of all NN intervals) and the clinical response to CRT assessed by NYHA class improvement and one-year mortality. This was a descriptive study that included 31 patients with symptomatic advanced heart failure in normal sinus rhythm treated with CRT in the cardiology department in the Military Hospital of Tunis. Results: All the time-domain HRV parameters were abnormally low in our population compared with baseline values in favor of sympathetic hypertonia and decreased parasympathetic tone. The alteration of HRV did not depend on the ischemic or non-ischemic nature of the underlying heart disease. Altered heart rate variability was proportional to the reduction of the left ventricular ejection fraction. In our study, a preserved baseline HRV (defined as SDANN>= 93 ms) was associated with a lower one-year mortality rate, a lower rate of rehospitalization for heart failure and a better clinical response to CRT. In multivariate analysis, preserved HRV appears to be a predictive factor of good response to CRT. These results are in agreement with those reported in the literature by various investigators: MUSILAK and all, KAMEN and all and others. Conclusions: The analysis of HRV and clinical response to CRT suggests that autonomic dysfunction identifies patients with limited benefit from CRT. Pre-implant HRV analyses may help to optimize qualification for CRT. Submission ID: 1609 ECHOCARDIOGRAPHIC EVALUATION IN NEONATES SUSPECTED TO CONGENITAL HEART DISEASE ELLA LAHMAIER, KAOUTHAR HAKIM, RIHAB BEN OTHMEN, MOHAMED AMINE SOULA, SABRINE SOUDANI, KARAM ZAREI, SYRINE BEN JEDDOU, CHAIMA GHORBEL, HELA MSAED, FATMA OUARDA TUNISIA Background: Congenital heart disease heart disease (CHD) is the most common congenital disorder in newborns. This condition have different presentations; from defects that can progress asymptomatically to complex anomalies with significant symptoms and high mortality. Objective: The aim of our study, was to assess the prevalence of CHDs among newborns referred to our department with clinical history and symptoms suggestive CHD. Methods: Monocentric, descriptive study performed on 300 newborn suspected to have CHD, referred to our cardio pediatric department for ultrasound examination, from March 2022 to July 2022. Patent ductus arteriosus and patent foramen oval in pattern newborns were exclude. Congenital heart disease (CHD) is the most form Results: From 300 included neonates, we noted male predominance of 56%. Sex ratio was 1,3. Prenatal diagnosis was made only in a limited number of patients, accounting for only in 32 (10%) infants. Heart murmur, cyanosis and oxygen dependence was main indications to transthoracic echocardiography (TTE) examination observed in 30, 22 and 15 respectively. Overall, echocardiographic findings were normal in 163 (54%) infants. Low risk-CHDs were found in 71(50%) patients; ventricular septal defect, atrial septal defect and atrioventricular septal defect was found in 35, 32, and 4 patients respectively. Medium risk-CHD were noted in 59 (32%) newborn. Among this group, we found mainly neonatal hypertension in 19% and tetralogy in 13%. High risk-CHDs such as truncus arteriosus, transposition of great arteries, total Anomalous Pulmonary Venous Return were found in 17 (10%). Conclusion: Our Results showed that almost half of symptomatic neonates was found to have CHD. This highlights the importance of clinical examination in newborns. Hence, our study gives the green light to a large prescription of ultrasound examination as soon as clinical abnormalities are found in newborns. Submission ID: 1616 POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS): IN YOUNG SUBJECTS (ABOUT 8 CASES) KARIM FATIHA, IMANE TLOHI, KHALIL MARIA, HAROUNA SEYDOU, FADOUL ADAM MOROCCO Introduction: Postural orthostatic tachycardia syndrome (POTS) is a common form of dysautonomia that is little known and underdiagnosed, especially in young people. It is an orthostatic intolerance associated with excessive tachycardia ≥ 30 bpm when standing (within 10 minutes) with multiple and recurrent somatic symptoms over 6 months. Its impact is major on the quality of life but the prognosis is most often favorable. Objective: The aim of this study is to underline the frequency and the impact of POTS on the quality of life and the interest of the exploration of the ANS to make the diagnosis. Patients and methods: This retrospective study includes a group of 8 patients with POTS from 19 to 28 years old (average age equal to 23.5 ± 4. years) followed in the cardiology department at the Casablanca University Hospital. Autonomic tests include deep breathing, isometric contraction, hyperventilation, orthostatic test and mental stress. MODERATED POSTER SESSION
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