CardioVascular Journal of Afr ica (off icial journal for PASCAR) www.cvja.co.za 33 JOINT MEETING The 23rd Panafrican Course on Interventional Cardiology and 27th National Congress of the Moroccan Society of Cardiology
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 2 Disclaimer The Abstracts for SMC-PAFCIC 2022 were reviewed by the PASCAR Interventional Cardiology Task Force (PASCI) and not by the Editorin-Chief, Regional Editors or reviewers of the Cardiovascular Journal of Africa. Only accepted and presented abstracts are published. Twenty third PanAfrican Course on Interventional Cardiology SMC-PAFCIC 2022 13-15 October 2022 PAFCIC Board: Founding President: Mohamed Ben Farhat Course Chairman: Habib Gamra Course Directors: Mohamed Ben Farhat Habib Gamra Horst Sievert Course Co-Directors: Kais Battikh Fethi Betbout Alain Cribier Jean Fajadet Mohamed Jeilan Augusto Pichard Fehmi Remadi Patrick Serruys Mohamed Sobhy Ahmed Suliman Scientific Board: Habib Gamra, Tunisia Horst Sievert, Germany Kamal Chitkara, United Kingdom Mohamed Jeilan, Kenya Awad Mohamed, Sudan Emmy Okello, Uganda Ahmed Suliman, Sudan Kais Battikh, Tunisia Samir Ahnia, Algeria Mpiko Ntsekhe, South Africa Sonia Chabrak, Tunisia Edoardo Camenzind, France Jonathan Byrne, United Kingdom Salim Ben Khedda, Algeria Samir Ztot, Morrocco Fatma Ouarda, Tunisia Mohamed Sobhy, Egypt Adel Bouraghda, Algeria Sami Mourali, Tunisia David Kettles, South Africa Yemi Jonhson, Nigeria Roland N’guetta, Cote d’Ivoire Patrick Serruys, The Netherlands Fethi Betbout, Tunisia Fehmi Remadi, Tunisia Alain Cribier, France Augusto Pichard, USA Live Transmission Sites: • Cedars Sinai Medical Center – Los Angeles, USA • Humanitas Research Center, Milan, Italy • Sunninghill Hospital, Johannesburgh, South Africa • international Medical Center, Jeddah, Saudi Arabia • University Hospital, Casablanca, Morocco • Kings College Hospital, London, United Kingdom
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 3 AFRICA
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 4 In Association with Africa Fellows Summit How to: Step by step 10:00 – 11:00 How to perform PCI of a long CTO lesion by antegrade approach Step by Step PAFCIC Hall Chairs: Fahd Chaara – Omer Goktekin – Hadi Abu-Hantash – Awad Mohammed – Fehmi Remadi Facilitators: Ahmed El Guindy – Marouane Boukhris Online Moderator: Majed Hassine Live from International Medical Center Jeddah – KSA Operator: Khalid Tammam Antegrade Wire Esclation: Strategies in difficult anatomies Omer Goktekin, Turkey Using wires safely and effectively Marouane Boukhris, France Antegrade dissection and re-entry: what works and Ahmed ElGuindy, Egypt what does not? Thursday October 13th, 2022 11:00 – 12:00 How to perform Balloon Mitral Valvuloplasty Step by Step PAFCIC Hall Chairs: Kanji Inoue – Rachid Mechmeche – Mohamed Ben Farhat – Assad Chaara – Essia Boughezala – Fethi Betbout – Naima El Haitem Facilitators: Jamel Langar – Nesma Ben Dagha How to perform transseptal Ahmed Suliman, Sudan Introducing the Inoue balloon Kanji Inoue, Japan How to negotiate the balloon to the mitral valve Assad Chaara, Morocco Challenging cases Habib Gamra, Tunisia Q&A
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 5 AFRICA Thursday October 13th, 2022 12:00 – 13:00 How to treat aortic coarctation Step by Step PAFCIC Hall Chairs: Abdelfattah Abid – Nadia Felat – Fatima Ouarda – Abdelelil Farhati – Horst Sievert – Fekria Abid – Faouzi Maatouk Facilitators: Elyes Neffati – Dorra Abid Imaging assessment Dorra Abid, Tunisia 10 min Indications for intervention Maiy ElSayed, Egypt 10 min Modalities of intervention: balloon or stent? Ilyes Neffati, Tunisia 10 min Live in-a-box case of aortic coarctation Horst Sievert, Germany 10 min Complications and late follow-up Semi Mourali, Tunisia 10 min 13:00 – 14:00 LUNCH 14:00 – 14:45 Live from Humanitas Research Hospital Milan – Italy PAFCIC Hall Operator: Antonio Colombo Chairs: Mohamed Sobhy – Augusto Pichard – Imad Al Haddad – Amine Jemel – Khaled Ould Beya – Wissem Sdiri Comtemporary approach of complex PCI in Multivessel Disease Debate: Management of complex MVD in 2022 PCI is preferred to CABG in most patients Gregg Stone, USA CABG is superior to PCI in most patients Imed Frikha – Amine Jemel, Tunisia 14:45 – 15:15 15:30 – 16:30 Live from University Hospital Casablanca Step by Step Operator: El Ghali Benouna Chairs: Alain Cribier – Augusto Pichard – Mohamed Sobhy – Leila Bezdah – Essia Boughezala – Imad Al Haddad – Abdallah Mahdhaoui Facilitators: Kamel Boughalem – Nadhem Hajlaoui
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 6 Thursday October 13th, 2022 16:30 – 17:30 Challenging cases of TAVI Chairs: Alain Cribier – Morched Marouane – Kamel Boughalem – Mpiko Ntsekhe – Adel Etriby – Semia Emez – Abdelfattah Abid TAVI in a patient with a Starr mitral prosthetic valve: Nadhem Hajlaoui, Tunisia Does it matter? Life time management ahead of time Kamel Boughalem, France TAVI in a patient with aortic homograft Imad Al Haddad, Jordan TAVI: problematic scenario, how to manage? Mohamed Sobhy, Egypt 17:30 – 18:00 Visit of exhibitions Moderated Poster Session 1 Moderators: Fares Azaiez – Mehdi Boussaada – Najat Mouine – Nabil Berrada 18:00 – 19:00 European Heart Journal @ SMC – PAFCIC SMC Hall Chairs: Filippo Crea – Abdelhamid Moustaghfir – Habib Gamra – Mohamed Alami – Saadia Abir – Abdoul Kane – Abdallah Mahdhaoui The year 2022: Top papers in ischemic heart disease in the Filippo Crea, Italy European Heart Journal Challenges with research in Africa Mpiko Ntsekhe, South Africa Tunisian experience with Multi-center Controlled Randomized Rania Hammami, Tunisia Trials in interventional cardiology Revascularisation of patients with left ventricular dysfunction: Bernard Gersh, USA How and when? 18:00 – 19:00 Keynote Lecture SMC Hall Chairs: Mohamed Ben Farhat – Abdelhamid Moustaghfir – Lillia Zakhama – Horst Sievert – Rachid Boujenah – Habib Gamra Lessons from 20 years of TAVI: Implications for the introduction Alain Cribier, France of TAVI in Africa 19:30 – 20:00 Official Opening Ceremony
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 7 AFRICA 08:30 – 09:30 Africa PCR @ PAFCIC Live transmission from Sunninghill Hospital, Johannesburg, South Africa SMC Hall Operator: Farrel Hellig Chairs: Stephen Lee – Mpiko Ntekhe – Horst Sievert – Mohamed Sobhy – Kais Battikh – El Ghali Benouna – Jonathan Byrne – Fehmi Remadi Facilitators: Habib Gamra – Yemi Johnson Introduction – session objectives Mpiko Ntsekhe, South Africa Live transmission from Johannesburg Operator: Farrel Hellig, South Africa Take home message Ahmed Sulliman, Sudan Friday October 14th, 2022 Complex PCI with physiologic assessment and imaging 09:30 – 10:00 Keynote lecture live from Japan Supported by Terumo SMC Hall Chairs: Samir Ztot – Faouzi Drissi – Yemi Johnson – Roland Nguetta – Nashwa Abderrahim – Maboury Diao Retrograde CTO PCI: Where are we now? Shozo Ishihara, Japan 10:30 – 11:00 Visit of Exhibitions Moderated Poster Session 2 SMC Hall Moderators: Hédi Ben Slima – Hichem Denguir – El Ghali Benouna – Amale Tazi 09:30 – 11:00 CSI Africa @PAFCIC PAFCIC Hall Chairs: Horst Sievert – Fatima Ouarda – Nadia Fellat – Maiy El Sayed – Ilyes Neffati – Habiba Drissa – Abdehadi Alkadidi – Max Amor Transcatheter closure of paravalvar leaks: Rationale, 10 min techniques and outcome. Recorded case paravalvar leak closure. 12 min Martin Swaans, The Netherlands Pulmonary valve implantation, devices, results 10 min Recorded case of pulmonary valve implantation 12 min Mario Carminati, Italy Acute stroke intervention 10 min Recorded case of acute stroke intervention 12 min Horst Sievert, Germany
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 8 12:00 – 13:00 Catheter base therapy for refractory angina Live from Kings College Hospital, London Operators: Jonathan Hill – Ian Webb Chairs: Youssef Ben Ameur – Sana Ouali – Emmy Okello – Mohamed Jeilan – Abdeddayem Haggui – Majed Hassine – Morshed Marouane Facilitators: Jonathan Byrne – Kais Battikh Friday October 14th, 2022 Phamacotherapy for refractory angina Giuseppe Rosano, UK 13:00 – 14:30 LUNCH 14:30 – 15:30 Innovation session Techniques you have never seen before Chairs: Stephen Lee – Adel Etriby – Jamel Langar – Khelil Hamza – Leila Hached – Habib Boussadia – Semi Milouchi – Omer Goktekin Facilitators: Zied Ibn Elhadj – Ahmed Suliman Rendezvous techniques for peripheral artery disease Max Amor, France 7 min Snowy biodegradable PFO device Horst Sievert, Germany 7 min Pulmonary arterio-venous malformation embolization Khelil Hamza, Tunisia 7 min A new technique to close the LAA without leaving a device Stefan Bertog, USA 7 min A new technique to repair left ventricular rupture Farrel Hellig, South Africa 7 min New transcatheter therapy for HFrEF patients Horst Sievert, Germany 7 min PAFCIC Hall 15:30 – 16:30 Live from Shaab Khartoum Hospital Left main bifurcation PCI Operator: Awad Mohamed Chairs: Saad Subahi – Patrick Joly – Hadi Abu-Hantash – Habib Ben Ahmed – Fethi Betbout – Ibrahim Touré – Skander Ben Omrane – Ahmed Suliman Facilitators: Jonathan Byrne – Mejdi Ben Messaoud PAFCIC Hall
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 9 AFRICA 16:30 – 17:00 Visit of exhibitions Moderated Poster Session 3 Moderators: Hichem Denguir – Meriem Drissa – Zainab Raissouni – Mohamed Alami PAFCIC Hall Operator: Raj Makkar Chairs: Augusto Pichard – Rachid Boujenah – Mohamed Sobhy – Aicha Aouad – El Ghali Bennouna – Imad Al Haddad – Lilia Zakhama – Ramesh Daggubati Facilitators: Horst Sievert – Habib Gamra Live Transmission Operator: Raj Makkar Friday October 14th, 2022 17:00 – 18:30 Live transmission from Cedar Sinai Medical Center, Los Angeles, USA SMC Hall Tricuspid Valve implantation and repair Keynote Lecture New devices for aortic, mitral and tricuspid repair Raj Makkar, USA
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 10 Saturday October 15th, 2022 Chairs: Ramesh Daggubati – Mirvat Alasnag – Adel Etriby – Nadham Hajlaoui – Ilyes Neffati – Habib Gamra Facilitators: Jamel Langar – Samir Ztot Algorithmic approach for a calcified lesion Mohamed Sobhy, Egypt Use of imaging to assess calcium Habib Ben Ahmed, Tunisia When and how to use guide extensions Adel Etriby, Egypt How to proceed with a non-dilatable lesion Abdullah Shehab, United Arab Emirates Rotational atherectomy – step by step Ramesh Daggubati, USA 10:00 – 11:00 How to approach a heavily calcified lesion? SCAI @ PAFCIC session Chairs: Sidi Mhamed Ould Ethmane – Jawad Chaara –Rania Hammami – Leila Hached – Samir Kammoun – Habib Boussadia – Mourad Gahbiche Facilitators: Mustapha Hattaoui – Fehmi Remadi How do I manage HBR patients with ACS in Tunisia Mejdi Ben Messaoud How do I manage HBR patients with ACS in Morocco Samir Ztot, Morocco How do I manage HBR patients with ACS in Kenya Mohamed Jeilan How do I manage HBR patients with ACS in Nigeria Yemi Johnson 08:30 – 09:15 How to manage a high bleeding risk patient with ACS PAFCIC Hall Chairs: Marouane Boukhris – Faouzi Maatouk – Ramesh Daggubati – Majed Hassine – Mourad Jarrar – Donia Ben Zerouel – Helmi Kammoun Facilitators: Awad Mohamed – Kais Battikh Case 1 Selim Boudiche, Tunisia One remaining vessel, which one to choose? Ghizlane Cherradi, Morocco Case 3 Hadi Abu-Hantash, Jordan Case 4 Nashwa Abderrahim, Sudan Case 5 Maboury Diao, Senegal Take Home Message Awad Mohamed, Sudan 09:15 – 10:00 Challenging cases of primary PCI
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 11 AFRICA Chairs: Abdelhamid Moustaghfir – Habiba Drissa – Youssef Ben Ameur – Maiy El Sayed – Soraya Ben Youssef – Leila Bazdeh – Faouzi Drissi – Abdeljelil Farhati LAA Closure: Atrial appendage closure in 2022: How and when? Habib Gamra 11:00 – 12:00 Left atrial appendage closure in 2022. How and when? Supported by Boston Scientific PAFCIC Hall Chairs: Stephen Lee – Helmi Kammoun – Mohammed Sobhy – Abdullah Shehab – Kamel Boughalem – Faouzi Addad – Zied Iln El Hadj Facilitators: Awad Mohamed – Wissem Sdiri A little move turns into a nightmare Michael Haude, Germany Complication a severly calcific lesion Damiano Regazzoli, Italy Unexpected shock during TAV1 Augusto Pichard, USA What you fear most during TAV1 Patick Joly, France A complicated left main PCI Jonathan Byrne, UK Unreported technique for lost stent retrieval Jamel Langar, Tunisia Unusual coronary perforation Max Amor, France Balloon rupture during valvuloplasty Ahmed Suliman, Sudan 12:00 – 14:00 Complications by The masters under the auspices of GTCI – AGIC – PASCI – CardioAlex PAFCIC Hall Saturday October 15th, 2022 Chairs: Abdelhamid Moustaghfir – Mohamed Ben Farhat – Horst Sievert – Habib Gamra The future of PCI: Transitioning from Ischemia to Gregg Stone, USA Vulnerable Plaque 14:00 – 14:30 Closing keynote lecture PAFCIC Hall Closing remarks / Meeting highlights Mohamed Ben Farhat – Habib Gamra – Horst Sievert 11:00 – 11:30 Visit of exhibitions Moderated Poster Session 4 Moderators: Mehdi Boussaada – Nashwa Aberrahim – Aicha Aouad – Aida Soufiani
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 12 Thank you to our partners
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 13 AFRICA Entry ID Name Surname Country English Title 1382 BENDAHOU HAJAR Morocco Alterations in left ventricular function in patients with aortic stenosis and preserved ejection fraction: the value of global longitudinal strain. Experience of the cardiology department at IBN ROCHD hospital university in Casablanca. 1383 BENDAHOU HAJAR Morocco Gender can influence parameters and prognosis of mitral stenosis? Experience of the Cardiology department of the IBN ROCHD Casablanca hospital center. 1388 Amira ABOURICHE Morocco Insights into the clinical course and therapeutic response of Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients: Casablanca Cardio-Oncology Unit experience 1392 oumayma Hattab Morocco A severe non-ischemic hypokinetic cardiomyopathy revealing an axial ankylosing spondylitis: a case report 1397 Ahmed Makni Tunisia Ostial stenting versus left main cross-over stentig in isolated ostial left anterior descending artery disease 1398 Fekih Ridha Tunisia Heart failure with preserved ejection fraction: Association between the left atrium strain and the NT-ProBNP 1400 HAJAR BENDAHOU Morocco Evaluation of right ventricular dysfunction concomitant to left ventricular dysfunction in cardiotoxicity induced by Trastuzumab in patients followed for HER2+ breast cancer: Experience of the cardio-oncology unit at IBN ROCHD hospital university, CASABLANCA. 1401 El Ghiati Hanaa Morocco Management of hypertension in severe forms of Posterior Reversible Encephalopathy Syndrom (PRES) 1402 Tamirat Moges Moges Ethiopia Rheumatic mitral valve regurgitation diagnosed after device closure of Secundum Atrial Septal Defect in a 6-year-old girl from Ethiopia: Case report. case report 1405 HAJAR BENDAHOU Morocco Diabetes mellitus predisposes to the risk of cardiovascular mortality in patients with breast cancer? Experience of the cardio-oncology unit at IBN ROCHD hospital university, CASABLANCA. 1426 Lokman Hafsa Morocco RIGHT VENTRICULAR THROMBUS REVEALING BEHCET’S DISEASE 1427 OUAOUICHA. HIND Morocco INFERIOR STEMI REVEALING TYPE A AORTIC DISSECTION 1435 ZAKARIA EL MARRAKI Morocco Postpartum dilated cardiomyopathy associated with Pulmonary embolism relevant to APS(antiphospholipid syndrom): a rare association (case report) 1436 ZAKARIA EL MARRAKI Morocco Post-covid myocarditis simulating acute coronary syndrome: 1437 ZAKARIA EL MARRAKI Morocco Coronary aneurysm: a rare etiology of coronary syndrome with St segment elevation (case report) : 1441 DAHMANI Houda Morocco MD 1444 MAHOUNGOU MACKONIA Noel Maschell Morocco Epidemiological study of infective endocarditis at the IBN Rochd University Hospital in Casablanca. 1448 SARA ABOURADI Morocco Type 2 diabetics presumed to be normotensive: Masked hypertension, urinary albumin excretion rate and echocardiographic screening 1452 SARA ABOURADI Morocco Prognostic value of diastolic dysfunction in acute myocardial infarction: a prospective study. 1455 EL-AZRAK MOHAMMED Morocco Sudden cardiac death risk stratification of the early repolarization syndrome: An updated review of the literature 1470 Abid Slim Tunisia Assessment of glycated hemoglobin predictivity in the severity of coronary artery disease in patients with or without diabetes 1475 BOUHADOUNE YOUSSRA Morocco Right ventricular infarction: Epidemiological, clinical and angiographic characteristics and the outcomes through the experience of a Moroccan cardiology department
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 14 1481 Zaid AMMOURI Morocco High risk pulmonary embolism : Management in CHU Ibn Rochd cardiology intensive care unit 1482 Boutaleb Amine mamoun Morocco Guidewire induced distal obtuse marginal perforation : Case report and review of litterature 1483 Boutaleb Amine mamoun Morocco Coronary artery stent total dislodgement in brachial artery 1489 Nouha Mekki Tunisia Late complications following Fontan procedure: a unicenter case series 1491 Nouha Mekki Tunisia Percutaneous reinterventions following the Fontan procedure 1494 OUERGHI MOHAMED HICHEM Tunisia Percutaneous treatment of a giant aneurysm of carotid with a covered stent 1499 MAHOUNGOU MACKONIA Noel Maschell Morocco CLINICAL FINDINGS AND CHARACTERISTICS OF CULTURE-NEGATIVE INFECTIVE ENDOCARDITIS 1503 Maaroufi Anass Morocco Basal characteristics of the cardio-oncology registry of chemotherapy induced cardiovascular toxicity: about 2329 patients 1504 EL MOUSAID MERIEM Morocco Influence of Direct Oral Anticoagulants on Rates of Oral Anticoagulation for Atrial Fibrillation 1505 Maaroufi Anass Morocco Prevalence, predictors and real-world management of NSTEMI with multivessel diseases 1506 MAAROUFI ANASS Morocco Infective endocarditis profile, prognostic factors and in-hospital mortality: 6-year trends from a tertiary university center in Morocco 1508 Amri Meriam Morocco Clinical characteristics and prognosis of surgical patients due to infective endocarditis 1511 Amri Meriam Morocco Heart failure in endocarditis patients: characteristics and prognosis 1516 Chaima Ghorbel Tunisia Pulmonary arterial hypertension in pediatric cardiology Epidemiological profile, management and survival in Tunisia 1518 charif hana Morocco A LOOK AT SUPPORT HEART FAILURE : EXPERIENCE OF THE HEART FAILURE TREATMENT UNIT OF THE IBN ROCHD UNIVERSITY HOSPITAL 1520 Syrine Benjeddou Tunisia Heart Rate Recovery after exercise in children 1521 Emna Derbel Tunisia Perforated balloon technique: a safe and simple method to deal with noreflow phenomenon 1525 charif hana Morocco Particularity of congestive heart failure in elderly versus young moroccan patients . 1526 Fatma Sghaier Tunisia Three vessels coronary artery disease; A challenge to treat in Tunisian conditions 1527 Fatma Sghaier Tunisia Clinical, anatomical and prognostic characteristics of coronary artery disease in Tunisian diabetics 1530 Ali Khorchani Tunisia Echocardiographic findings in patients with improved heart failure 1531 BENOTHMAN Rihab Tunisia Pulmonary Valve Replacement After Tetralogy of Fallot Repair 1532 charif HANA Morocco Paradox of obesity is it valid in Moroccan patients followed with chronic heart failure with reduced ejection fraction ? 1533 Ali Khorchani Tunisia Clinical characteristics of patients with improved heart failure 1534 Taha Lassoued Tunisia Acute coronary syndrome revealing a Behcet’s Syndrome in a young man 1535 charif hana Morocco Sex-related differences in the incidence and prognosis of heart failure with impaired ejection fraction: an experience from the UHC Ibn Rochd of Casblanca, Morocco (about 4382 patients) 1537 Chawki Khawla Morocco The changing face of infective endocarditis over time : over 30 years comparative study 1539 Hala El Assili Morocco CHALLENGING PERSISTENT LEFT SUPERIOR VENA CAVA FOR CARDIAC DEVICE IMPLANTATION : TWO CASE REPORTS AND LITERATURE REVIEW 1547 Zaid Ammouri Morocco OUTCOMES AND PROGNOSIS OF ACUTE CORONARY SYNDROMES IN DIABETIC PATIENTS Entry ID Name Surname Country English Title
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 15 AFRICA 1548 HATIM HAJAR Morocco Moroccans' modifiable risk factors of severe heart failure : a descriptive study using routinely collected health database 1553 ETTACHFINI TAHA Morocco Arrhythmogenic Right Ventricular Cardiomyopathy Revealed by Ventricular Tachycardia 1554 ZAINAB BOUDHAR Morocco Atrial Fibrillation After Ischemic Stroke Detected by 24 hours Chest Holter Monitoring 1560 Skander Bouchnag Tunisia Biological predictive factors of in-hospital mortality in cardiogenic shock in the setting of STEMI. 1564 choukrani hanane Morocco Anemia as a severity factor in patients with myocardial infarction 1573 Bousnina Mouna Tunisia Paraortic ectopic thyroid: a case report 1574 HAJAR BENDAHOU Morocco Role of the inflammatory biomarkers to detection of the chronic progression rheumatic valvular diseases: Moroccan experience of the cardiology department at the CHU IBN ROCHD, CASABLANCA 1578 Bousnina Mouna Tunisia Axillary artery aneurysm revealed by acute ischemia of the upper extremity 1579 MAAROUFI ANASS Morocco qSofa score: a useful score to identify patients at risk of poor prognosis in infective endocarditis 1581 Marwa Abdelhedi Tunisia The impact of left ventricular geometry in right heart function in hypertensive patients. 1582 MAAROUFI ANASS Morocco Toxic cardiomyopathy due to Trastuzumab’s use in breast cancer patients in the cardio-oncology unit of Casablanca . 1583 Marwa Abdelhedi Tunisia The Impact of overweight in left atrial and left ventricular structure and function in hypertensive patients. 1588 AMINE BOUCHLARHEM Morocco The impact of prior antithrombotic use on thromboembolic events in patients with cardiovascular disease and severe COVID-19 infection. 1595 Abderrahmane Bouchaala Morocco Too much sugar blocks your heart? Sinoatrial arrests associated with diabetic ketoacidosis regressing to sinus rhythm after compensation of diabetic process 1600 NABAWI HIND Morocco Prosthetic valve thrombosis: a real challenge for caregivers (a case series of 9 patients ) 1606 Hamdi Sana Tunisia Prognostic value of Heart Rate Variability in patients treated with Cardiac resynchronization therapy ;Cardiology department, Military Hospital of Tunis 1609 Ella Lahmaier Tunisia Echocardiographic Evaluation in Neonates Suspected to Congenital Heart Disease 1616 KARIM Fatiha Morocco POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS): in young subjects (about 8 cases) 1623 HAYAR SALAH EDDINE Morocco Infective endocarditis with low C-reactive protein: is it worth considering? 1626 Amine Boufares Tunisia IMPACT OF DIPPER PROFILE ON TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK IN HYPERTENSIVE PATIENTS. A PROSPECTIVE STUDY 1627 zainab Boudhar Morocco Prevalence of arrhythmias on 24‑h ambulatory Holter electrocardiogram monitoring: from 24-h ambulatory holter electrocardiogram register of Mohammed VI university hospital of Marrakech. 1630 AMAMOU IMEN Tunisia Percutaneous treatment for complex coarctation of the aorta 1632 Ali Khorchani Tunisia A new feasible and safe access point in interventional cardiology : The trans-palmar acess 1633 Aiman Ghrab Tunisia Automatic coronary angiogram analysis algorithm: keyframe extraction phase 1634 Samia EJJEBLI Morocco Epidemiology and prognosis of coagulase-negative staphylococcal endocarditis Entry ID Name Surname Country English Title
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 16 1638 karim fatiha Morocco HIGH-GRADE ATRIO-VENTRICULAR BLOCK in young subjects SECONDARY TO VAGAL HYPERACTIVITY (About 3 cases) 1642 denguir hichem Tunisia Outcomes in ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention or pharmacoinvasive strategy in a single Tunisian center 1643 Hajri Yassmine Tunisia Noninvasive cardiovascular evaluation of patients with erectile dysfunction 1644 Kaouthar Hakim Tunisia Long-term outcomes in congenitally corrected transposition of the great arteries: La Rabta hospital experience 1645 Hajri Yassmine Tunisia Severity of erectile dysfunction and cardiovascular risk: a prospective study 1647 TAOUSSI OUMAIMA Morocco Epidemiological and etiological profile of Atrial Fibrillation: A Moroccan study 1653 Talhaoui Amira Tunisia Predictive factors for reoperation and death in operated atrioventricular ducts 1662 Asma Brahim Tunisia Contribution of the speckle tracking in the evaluation of left ventricule filling pressure in acute coronary syndromes 1664 Asma Brahim Tunisia The Correlation between 2D global longitudinal strain Echocardiography and Cardiac magnetic resonance to determine left ventricle myocardial scar burden (LVMS) in patients presenting with acute coronary syndrome (ACS) 1666 Bousnina Sabrine Tunisia Discordance between high gradients and moderately stenotic valve surfaces : A rare cause not to be ignored! 1668 HAYAR SALAH EDDINE Morocco Insights about unsual germs in infective endocarditis. 1676 fagouri jihane Morocco FALSE PANCREATITIS REVEALING INFECTIVE ENDOCARDITIS 1677 Abdeljelil Farhati Tunisia Successful recovery of central venous catheter fragment from the right atrium and right ventricle 1678 Abdeljelil Farhati Tunisia Percutaneous transcatheter closure of mitral prosthetic paravalvular leaks: a case report 1682 Zineb Fassi Fehri Morocco EFFECTS OF PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY ON LEFT VENTRICULAR, RIGHT VENTRICULAR AND LEFT ATRIAL DEFORMATION IN PATIENTS WITH ISOLATED AND SEVERE MITRAL STENOSIS : A STRAIN ANALYSIS. 1683 Zineb AGOUMY Morocco Surgical outcomes of patients with severe aortic regurgitation within markedly reduced left ventricular function: why should we operate 1684 SAMAH EL-MHADI Morocco Spectrum of cardiovascular involvement in Behçet Disease: Not only thrombosis! 1690 MAHOUNGOU MACKONIA Noel Maschell Morocco Relationship between cardiovascular risk and nocturnal systolic-diastolic arterial pressure in hypertensives at CHU-IBN Rochd. 1691 choukrani hanane Morocco Assessment of left diastolic function in patients with metabolic syndrome 1694 Badreddine Ben Kaab Ben Kaab Tunisia Pulse pressure is a predictive tool of cardiovascular events in Tunisian hypertensive patients 1695 Badreddine Ben Kaab Ben Kaab Tunisia Ambulatory blood pressure measurement : profile and correlation with cardiovascular events in treated hypertensive patients 1697 Sarra Chadli Morocco Intracardiac thrombosis and vascular involvement in Behçet's disease : two sides of the same coin? 1698 NAWEL DAHIMENE Algeria Runaway pacemaker phenomenon : when a patient almost passed away 1704 Belghait El Hajjaj Morocco An exceptional observation of a Ticagrelor induced delusion 1705 Benssied Asmae Morocco PROPHYLACTIC PACEMAKER IMPLANTATION IN STEINERT DISEASE: Case Report Entry ID Name Surname Country English Title
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 17 AFRICA Entry ID Name Surname Country English Title 1710 MALAK BENABDELLAH Morocco Complete heart block and pregnancy : a management dilemma 1714 Kamal Marzouki Morocco Myocardial infarction after Covid-19 vaccination: a causal link? 1717 NABAWI HIND Morocco poster: Prognostic factors of mortality during infectious endocarditis in the University Hospital of Marrakech 1723 Ben Salem Amal Tunisia Treatment of coronary bifurcation lesions with two-stent techniques: short- and long-term outcome in a north african referral hospital 1725 skander bouchnag Tunisia Drug-eluting versus bare-metal stents: is it a matter of vessel size? 1726 skander bouchnag Tunisia Vessel Size and Long-Term Outcome After Percutaneous Coronary Intervention With Drug Eluting Stent 1728 LARAICHI Zakariae Morocco Renal Artery Angioplasty in patients with Kidney Failure in Patients With Severe Atherosclerotic Renal Artery Stenosis and ischemia documented by ultrasound resistance index: a retrospective study of 48 consecutive patients. 1729 LAMYAA BAKAMEL Morocco Ventricular Septal Defect Post-Myocardial Infarction: About 7 Cases 1731 skander bouchnag Tunisia Concomitant Coronary Stent and Femoral Artery Thrombosis in the Setting of Heparin-induced Thrombocytopenia 1736 Chadli Sarra Morocco Cardiac amyloidosis : a race against time 1739 EL MIRE WAFA Morocco ALL IN ONE: THE 3 P PARADOXICAL EMBOLIC STROKE AND PULMONARY EMBOLISM IN A PATIENT WITH A PATENT FORAMEN OVAL 1740 Aissa mohamed selmen Tunisia Electrocardiographic criteria for left ventricular hypertrophy in aortic valve stenosis: Correlation with echocardiographic parameters 1742 Boudiche Selim Tunisia Two-Stent Strategies for the Treatment of Unprotected Left Main Bifurcations Lesions. A Five-Year Monocentric Experience. 1746 Boudiche Selim Tunisia Transcatheter Aortic Valve Implantation: Initial Experience and One-Year Outcomes from a Single Institute in Tunisia. 1751 Meryem Iben chekroun Iben chekroun Morocco Cardiovascular Magnetic Resonance in Cardiac Amyloidosis 1752 Houdhayfa HERMASSI Tunisia Neurological events are still a serious complication of infective endocarditis 1753 Houdhayfa HERMASSI Tunisia Usefulness of 64-slice multidetector computed tomography to detect coronary disease in patients prior to cardiac valve surgery 1754 Azaiez Fares Tunisia Angiographic features of myocardial infarction in young women 1756 Meriem Lamhani Morocco Cardiac arrythmias on hemodialysis 1759 Azaiez Fares Tunisia Female patients with myocardial infarction and non obstructive coronary arteries (MINOCA): Clinical characteristics, in-hospital complications and long-term mortality. 1761 Azaiez Fares Tunisia Myocardial infarction in young women: clinical profile and long term outcomes. 1762 Azaiez Fares Tunisia Impact of prior coronary artery bypass grafting in patients with an acute coronary syndrome 1764 Azaiez Fares Tunisia Angiographic factors associated with stent thrombosis 1765 Azaiez Fares Tunisia Prognosis of stent thrombosis 1766 Azaiez Fares Tunisia Angiographic profile of patients over the age of 75 years old presenting with acute coronary syndrome 1767 Azaiez Fares Tunisia Mid and long-term follow-up of patients aged over 75 years with acute coronary syndrome. 1770 Azaiez Fares Tunisia ST-Segment-Elevation Myocardial Infarction in COVID-19
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 18 MODERATED POSTER SESSION Submission ID: 1382 ALTERATIONS IN LEFT VENTRICULAR FUNCTION IN PATIENTS WITH AORTIC STENOSIS AND PRESERVED EJECTION FRACTION: THE VALUE OF GLOBAL LONGITUDINAL STRAIN. EXPERIENCE OF THE CARDIOLOGY DEPARTMENT AT IBN ROCHD HOSPITAL UNIVERSITY IN CASABLANCA. H. BENDAHOU, M. NJIE, K. BADAOUI, S. ABOURADI, Z. SOUKAINA, M. NJIE, M. AMRI, M. TAMIR, M. HABOUB, S. AROUS, G. BENNOUNA, A. DRIGHIL, L. AZZOUZI, R. HABBAL MOROCCO Introduction: Left ventricular longitudinal systolic function as well as longitudinal global strain (GLS) represent sensitive markers of subclinical LV systolic dysfunction. They are often altered in tight calcified aortic stenosis (AS) while the ejection fraction (LVEF) is preserved for a long time. The objective of our study was to assess the degree of early impairment of LGS and LV longitudinal systolic function compared to LVEF, thus their prognostic value in tight AS. Materials: We conducted a prospective study, fromOctober 2017 to June 2022, on patients with valvulopathies, collected from the day hospital, at the cardiology department of the CHU Ibn Rochd in Casablanca. We compared patients with tight BCR (G1) and those with moderately tight BCR (G2) and compared LVEF to SGL and peak S wave at the mitral annulus (S’VG) in the 2 groups. Results: Over the 4 years of study, out of a total of 720 patients with valvular heart disease, 252 had AS, 101 of which were isolated (39.9%). The mean age was 58.6 years (+/-10), with a sex ratio (M/F) of 0.7. The mean LVEF was 56.15% in G1 and 57.2% in G2, the mean SGL was -14.1+/- 3.34% in G1 versus -16.1+/- 4, 01% in the G2. LVS was significantly more altered in G1 (average LVS at 6cm/s versus 13cm/s in G2). SGL was altered while LVEF was still preserved in 68% and 34% respectively in the 2 groups (p=0.82 and 0.02). Submission ID: 1383 GENDER CAN INFLUENCE PARAMETERS AND PROGNOSIS OF MITRAL STENOSIS? EXPERIENCE OF THE CARDIOLOGY DEPARTMENT OF THE IBN ROCHD CASABLANCA HOSPITAL CENTER H. BENDAHOU, S. ZAHRI, M. NJIE, K. BADAOUI, E. TAMIR, M. AMRI, M. HABOUB, S. AROUS, G. BENNOUNA, A. DRIGHIL, L. AZZOUZI, R. HABBAL MOROCCO Introduction: Mitral stenosis (MS) is the most common valvular disease in Morocco, often due to acute articular rheumatism. It affects women more frequently. The aim of our study was to compare the clinical and echocardiographic characteristics qnd prognosis of MS according to gender. Materials and methods: We conducted a prospective study, fromOctober 2017 to June 2022, on patients with valvulopathies, collected from the day hospital, at the cardiology department of the CHU Ibn Rochd in Casablanca. We compared 2 groups: Group I (men), Group II (women). Study analysis was performed using SPSS version 20 software. Results: Over the 4 years of study, out of a total of 720 patients with valve disease, 331 patients had an MS (46%), of which 194 were tight. The average age was 60 years (+/- 10.27), with a sex ratio (M/F) of 0.7. We formed two groups: 96 men 28.9% (group I) and 235 women 71.1% (group II). Comparison of clinical data (history of rheumatic fever, repeated angina, stage of dyspnea, palpitations) revealed no significant difference, however there is a higher incidence of left atrial electrical hypertrophy in group I (p <0.001). Regarding the echocardiographic data, in men, the left atrium was more dilated (p=0.049), the mitral surface was tighter (p=0.024) and the right ventricular dilatation was more frequent (54% vs 28% with p=0.036). There was no significant difference in mean gradient, calcifications and therapeutic indication. Conclusion: Our study suggests that MS in humans is more severe with more impact on the size of the left atrium as well as on that of the right ventricle, without valvular anatomical difference and therefore without influence on the therapeutic indications. Submission ID: 1388 INSIGHTS INTO THE CLINICAL COURSE AND THERAPEUTIC RESPONSE OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY IN BREAST CANCER PATIENTS: CASABLANCA CARDIO-ONCOLOGY UNIT EXPERIENCE AMIRA ABOURICHE, HAJAR BENDAHOU, ANASS MAAROUFI, SOUKAINA ZAHRI, SAMIA EJJEBLI, LEILA AZZOUZI, RACHIDA HABBAL, SOUKAINA LABDELLAOUI, SOUHA SAHRAOUI, NEZHA TAWFIQ MOROCCO Background Anthracycline-induced cardiotoxicity is a rapidly evolving disease that can lead to chronic heart failure. Despite dosing limitations, the prevalence of anthracycline-induced cardiac dysfunction is estimated to be 6% for explicit heart failure and up to 18% for subclinical cardiac dysfunction. The purpose of this study was to determine the clinical significance of anthracycline-induced cardiomyopathy (AC-CMP) and its response to treatment for heart failure (HF). Methods We included 121 patients with a > 10% decrease in left ventricular ejection fraction (LVEF) with a value < 50% due to AC-CMP and Figure 1: Major Cardiac Events in the 3 Study Groups Conclusion: Our study showed the interest of the systematic evaluation of the systolic longitudinal function of the LV as well as the SGL since an alteration of these parameters influences the prognosis of patients with AS, which underlines the importance of incorporate GLS into AS evaluation algorithms.
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 19 AFRICA after exclusion of coronary artery disease. LVEF was measured at enrollment and remeasured periodically during a mean follow-up of 26 ± 8 months. Patients were classified as responders, partial responders, or non-responders based on their LVEF recovery. Serious adverse cardiac events were also recorded during the follow-up period. Results Treatment of HF had a response rate of 22%, a partial response rate of 33%, and a nonresponse rate of 45%. Comparing responders, partial responders and non-responders, responders had a lower rate of cumulative cardiac events (8%, 22% and 44%, respectively; p 0.003) (Fig.1). The percentage of responders decreased with increasing time between the end of chemotherapy and the start of HF treatment; no complete recovery of LVEF was observed after 11 Submission ID: 1392 A SEVERE NON-ISCHEMIC HYPOKINETIC CARDIOMYOPATHY REVEALING AN AXIAL ANKYLOSING SPONDYLITIS: A CASE REPORT OUMAYMA HATTAB, NOHA EL OUAFI MOROCCO Background Ankylosing spondyloarthritis is a chronic rheumatis disease that affects the vertebral colon and sacroiliac joint primarily, and peripheral joints secondly. Meanwhile it can have an extra articular manifestations such as cardiac, pulmonary, ophthalmologic, and neurologic. Cardiovascular involvement is a well-known side effect of AS, associated to a higher mortality and morbidity rate, the disease spectrum is large, comprising aortitis, valvular heart disease, conduction abnormalities, and cardiomyopathy. Interestingly, dilated cardiomyopathy has been associated with ankylosing spondylitis and reported in only in a few cases in the literature, but the pathophysiological mechanisms of this association remain poorly understood. Here we report a case of a 50 year old male without additional cardiovascular risk factors who was admitted to our cardiology department to manage an acute heart failure, his routine blood test were normal, he had normal coronary arteries on cardiac catheterization and his transthoracic echocardiography showed a newly severe hypokinetic cardiomyopathy, further investigations revealed ankylosing spondyloarthritis (AS) fortuitously diagnosed. He responded well to diuretics and non-steroidal anti-inflammatory drugs. The patient reported an improvement in his cardiac and joints symptoms, and repeat echocardiography showed an improvement Submission ID: 1397 OSTIAL STENTING VERSUS LEFT MAIN CROSSOVER STENTIG IN ISOLATED OSTIAL LEFT ANTERIOR DESCENDING ARTERY DISEASE AHMED MAKNI, TARAK ELLOUZE, SALMA CHARFEDDINE, RANIA HAMMAMI, AFIF REKIK, AMINE BAHLOUL, SOUAD MALLEK, FATEN TRIKI, MOUNA HENTATI, AIMAN GHRAB, LEILA ABID TUNISIA Introduction: Ostial lesion of left anterior descending coronary artery (LAD) remains challenging because of the unpredictable involvement of distal left main coronary artery (LM) which has been already suggested in intravascular ultrasound studies . Objective: We evaluated the impact on short, mid and long-term outcomes of ostial LAD disease treated by means of ostial stenting (the floatingstent) or left main (LM)-to-LAD cross-over stenting Methods: We included all patients ,between the 1st October 2012 and the 1st May 2018, with significant and isolated stenosis of the ostial LAD (ostium or the first 3 mm at the origin of the LAD) objectified at the coronary angiography and treated by percutaneous coronary intervention (PCI). A stenosis of the ostial LAD was considered significant if it is judged to be ≥50% at the coronary angiography. The complexity of the lesions and coronary disease was evaluated months (Fig. 2). Conclusion AC-CMP early detection and appropriate HF treatment can lead to an improvement in LVEF and a decrease in cardiac events. This highlights the importance of establishing a monitoring pathway using biomarkers and echocardiography. of his ejection fraction. AS is part of the group of chronic inflammatory that can have many extra articular manifestations including the cardiac injuries with poor outcomes. This association which remain rare and not sufficiently studied. Among this case we aim is to highlight the cardiac injuries in patient with ankylosing spondylitis (AS). Figure 2: Percentage of Responders Based on Time between Anthracycline end and HF Therapy initiation MODERATED POSTER SESSION
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 20 Submission ID: 1398 HEART FAILURE WITH PRESERVED EJECTION FRACTION: ASSOCIATION BETWEEN THE LEFT ATRIUM STRAIN AND THE NT-PROBNP RIDHA FEKIH, SAOUSSEN ANTIT, MARWA ABDELHEDI, KALTHOUM DRIDI, ELHEM BOUSSABEH, LILIA ZAKHAMA TUNISIA Background: Plasma concentration of NT-ProBNP is recommended as initial diagnostic test in patients with symptoms suggestive of Heart failure (HF) with preserved ejection fraction (HFpEF). The Peak atrial longitudinal strain (PALS) has been proposed as an alternative approach for left ventricular diastolic function assessment. Thus, we searched for a correlation between the PALS and the NT-ProBNP in patients with suspected HFpEF. Methods: This is a prospective descriptive study that included 67 patients with suggestive symptoms of HF, explored in the cardiology department of the hospital of the internal security forces of Marsa and having consulted between November 2021 and Mars 2022. Results: The mean age was 60±11 years, with a sex ratio of 0.76. Hypertension and obesity were the most common cardiovascular risk factors (80% and 51% respectively). Explorations objected a median NT-ProBNP of 76 mmHg [49-143] and a median PALS of 30.2 [23-32.4]. A value of NT Pro-BNP ≥125 pg/ml was found in 33% of the patients. In univariate analysis, PALS was significatively lower in patients with NT Pro-BNP ≥125 pg/ml (p= 0.02). In bivariate analysis, PALS was significatively and negatively correlated with NTPro BNP (p= 0.003, r= -0.36. The analysis of the Receiver operating characteristic curve showed that a value of PALS < 30.2 (sensibility= 63%, specificity= 77%) increases the likelihood of NT-Pro BNPI ≥125 pg/ml by 5.6 (OR= 5.6, 95% CI: 1.72-18.1). Conclusion: PALS, easily measured by echocardiography, could be used as an alternative parameter in the diagnosis of HFpEF. Keywords: Heart failure with preserved ejection fraction, NT-ProBNP, Left atrium strain. Table 1: Results of the comparative study between the two groups according to the technique of angioplasty according to ACC / AHA classification of coronary lesions. Patients have been stratified according to the stenting techniques adopted: ostial stenting (OS) or LM cross-over (CO). The primary endpoint was the occurrence of major cardiocerebrovascular events (MACCE) during the follow-up period of 12 months Results: Sixty consecutive patients (49 males, mean age 63.9±10.8 years old) have been analyzed. In CO patients the SYNTAX score (23.2±3.6 vs 17.9±4.2, p=0.04). On a mean follow-up of 11.06± 1.9 months, major adverse cardiac events (MACE) and target vessel revascularization (TVR) were 26.6%. Restenosis was higher in the OS than in CO group of patients and was located angiographically at the ostium (p =0.02). The 60 lesions of ostial LAD and associated lesions were revascularized. Two revascularization strategies were adopted: 50% (n = 30) of the patients had initially a “provisional-T-stenting” of the distal TCG bifurcation against 50% (n = 30) of patients who had ostial implantation stent with a slight protrusion in the LM bifurcation. The stenting procedure: the “float stenting technique” was associated Figure 1: Angioplasty of the ostial IVA according to the technique TCG - IVA Figure 2: Angioplasty of the ostial IVA according to the technique Floating stenting in one of our patients with a higher MACCE risk. The MACCE rate was higher with floating stenting in the order of 21.6% compared to 8.3% for cross-over stenting, with a statistically significant difference (p = 0.02). Conclusion: On long-term follow up CO appeared superior to OS technique for isolated ostial LAD disease particularly in calcified lesions. MODERATED POSTER SESSION
CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 21 AFRICA Submission ID: 1400 EVALUATION OF RIGHT VENTRICULAR DYSFUNCTION CONCOMITANT TO LEFT VENTRICULAR DYSFUNCTION IN CARDIOTOXICITY INDUCED BY TRASTUZUMAB IN PATIENTS FOLLOWED FOR HER2+ BREAST CANCER: EXPERIENCE OF THE CARDIO-ONCOLOGY UNIT AT IBN ROCHD HOSPITAL UNIVERSITY, CASABLANCA. H. BENDAHOU, A. ABOURICHE, A. MAAROUFI, S. BELKOUCHIA, H. KARMOUCHI, S. ZAGDANE, S. EJJEBLI, M. HABOUB, S. AROUS, G. BENNOUNA, R. HABBAL, S. ZAFAD, M. DAKIR, K. FARES ARAB, S. SAHRAOUI, N. TAWFIK MOROCCO Introduction: Trastuzumab (TZ), a monoclonal antibody, is used for the treatment of HER2- positive breast cancer, with a marked improvement in its prognosis. However, it is associated with significant left ventricular (LV) cardiotoxicity. But TZ related right ventricular (RV) dysfunction and its prognostic implications have rarely been reported. Objective: Determine the incidence and prognostic value of RV dysfunction cardiotoxicity. Method: We conducted a prospective study carried out at the Casablanca cardio-oncology unit from January 2017 and April 2022. The echocardiographic evaluation is carried out pre and post chemotherapy. LVEF, RV Function (Systolic Tricuspid Annulus Plane Excursion (TAPSE) and Peak the S wave in pulsed tissue Doppler mode (S’VD), pulmonary arterial pressure (PAPS), Vmax of the TI, the size of the IVC, were measured by echocardiography. Results: A total of 2329 patients were recruited to the cardio-oncology unit with a total of 2284 patients diagnosed with breast cancer, the average age was 53 ± 11 years. Of these patients, 1338 (58.6%) were on Trastuzumab. Trastuzumab-induced cardiotoxicity (TIC) was defined as a decrease in LVEF >10% at the lower limit of normal of 50%, after administration of trastuzumab. An alteration of LVEF was found in 306 cases (13.4%). Of this patients, 214 (70%) were symptomatic. Concerning the alteration of the RV concomitant with the alteration of the LV, 51 patients (16.8%) had a TAPSE<17mm with an S’RV<9.5m/s, with signs of right overload defined by PAPS>34mmHg in 18 patients, Vmax>3,4m/s in 14 patients, and dilated IVC in 13 patients. During the follow-up, the cessation of chemotherapy for all patients associating the biventricular alteration was mandatory with administration of the treatment of heart failure: beta-blocker, ACE inhibitor, and Aldactone and close monitoring every month. Reversibility was noted in 17 patients with biventricular cardiotoxicity, with a control LVEF of 53%±5, and a TAPSE>18mm, after 6 months of post-chemotherapy follow-up. Conclusion: TIC in patients with HER2+ breast cancer is often reversible. But the presentation of a concomitant dysfunction of the LV and the RV makes this reversibility weaker. This suggests that RV dysfunction has very important prognostic value and its persistence during follow-up needs to be evaluated in further studies. Submission ID: 1401 MANAGEMENT OF HYPERTENSION IN SEVERE FORMS OF POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROM (PRES) H.EL GHIATI, J. FAGOURI, N. MOUINE, A. BENYASS, H.BALKHI MOROCCO Background: The PRES is a clinical-radiological syndrome indicating spontaneously reversible brain suffering. It combines essentially neurological manifestations with white matter signal abnormalities in magnetic resonance imaging. The aim of our work is to focus on the clinical and evolutionary features of severe forms of PRES in order to identify therapeutic (especially the management of hypertension) and prognostic considerations. Materials and methods: This is a retrospective study conducted in the surgical intensive care unit (ICU) of the Mohamed V Military Training Hospital of Rabat over a period of 13 years including severe forms of PRES. Results: Eleven cases of PRES in its severe forms have been collected. The average age was 30 years with a clear predominance of women (90.91%). High blood pressure was present in all cases. Neurological signs were mainly represented by generalized seizures, headache and confounding syndrome. Two patients had status epilepticus, while one had respiratory distress following acute pulmonary edema. In addition, one patient had brainstem injury. After adequate medical management, the evolution was favorable in all patients with complete clinical-radiological reversibility despite their initial severity. Conclusion: Management of hypertension is crucial in serious forms of PRES. An adapted treatment helps prevent permanent neurological sequelae and ensure clinical-radiological reversibility. MODERATED POSTER SESSION
AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 22 Submission ID: 1402 RHEUMATIC MITRAL VALVE REGURGITATION DIAGNOSED AFTER DEVICE CLOSURE OF SECUNDUM ATRIAL SEPTAL DEFECT IN A 6-YEAR-OLD GIRL FROM ETHIOPIA: CASE REPORT. CASE REPORT TAMIRAT MOGES, HELEN MINTESINOT, KUMELACHEW GETAHUN, ALI DAWD MOHAMED ETHIOPIA Background: Severe mitral valve regurgitation and Atrial septal defect are seldom reported due to rheumatic etiology. Objective: - We aimed to report an unusual coincidence of Atrial septal defect (ASD) with rheumatic mitral valve regurgitation (RMVR) and to discuss the clinical findings. Case report: A 6-year-old female child was treated with transcatheter closure of a large ASD (15mm) using a 17 mm size Amplatzer septal occluder (ASO) some 2 years back. MV apparatus was reported normal at the initial and the post-operative echocardiographic study. One year and 7 months after her procedure, she presented to the pediatric emergency ward with shortness of breath, orthopnea, paroxysmal nocturnal dyspnea and bilateral pedal edema. She was admitted as NYHA class 4, class C heart failure. She had cardiomegaly on the Chest X-ray. ECG showed bi-atrial and ventricular enlargement. Echocardiographic study showed well-functioning ASO in its proper position without dislodgement or impingement of the device on the valve leaflets. The anterior mitral valve leaflet (AMVL) was markedly thickened and had restricted motion. The posterior mitral valve leaflet (PMVL) was also thickened and foreshortened. Color-doppler study showed severe eccentric MR. A diagnosis of well-functioning ASD device with severe RMVR was made and secondary prophylaxis was started with benzathine penicillin 600,000 iu IM on monthly basis. She was treated for heart failure and discharged in good condition to be linked to the cardiac surgery unit. Discussion: MV disease coexisting with an ASD could either be congenital or acquired. The echocardiographic finding in the current patient fulfils the world heart federation (WHF) criteria for the diagnosis of RHD. In addition, the patient is from rheumatic fever high endemic area and the common complications of ASO described in the literature were absent. Although, device-associated damage of the MV is considered when an oversized ASD-device causes continuous traction on the insufficient rim to the mitral annulus resulting in annular dilatation, the size of the ASO used in the current patient was appropriately sized. The current case report helps to draw attention to the uncommon association of severe RMVR with transcatheter closure of a large ASD and shares a similar experience. Conclusion: This is a rare coincidence between congenital ASD with RMV disease which requires careful investigation and decision. Keywords: ASD, Rheumatic, Mitral regurgitation Submission ID: 1405 DIABETES MELLITUS PREDISPOSES TO THE RISK OF CARDIOVASCULAR MORTALITY IN PATIENTS WITH BREAST CANCER? EXPERIENCE OF THE CARDIO-ONCOLOGY UNIT AT IBN ROCHD HOSPITAL UNIVERSITY, CASABLANCA. H. BENDAHOU, A. ABOURICHE, A. MAAROUFI, Y. ETTAGMOUTI, H. KARMOUCHI, Z. AMMOURI, S. BELKOUCHIA, M. HABOUB, S. AROUS, G. BENNOUNA, R. HABBAL, M. DAKIR, S. ZAFAD, K. FARES ARAB, S. SAHRAOUI, N. TAWFIK MOROCCO Introduction: Type 2 diabetes mellitus (DM) is a known cardiovascular disease (CVD) risk factor that is also associated with an increased risk of breast cancer (BC) and a poorer prognosis according to recent studies. Objective: The aim of our study was to assess the impact of DM on all cause, cancer-specific, CVD-related and kidney-disease mortality in BC patients. Methods: This retrospective study included 2284 female BC survivors recruited from the registry of the cardio-oncology unit of Casablanca, who were diagnosed with primary invasive BC between 2017 and 2022 and an age-matched comparison group without BC. We estimated multivariable-adjusted hazard ratios (HRs) for mortality rates with 95% confidence intervals (CI). Results: Among BC patients (N=2284), over a median follow-up of 8 years, we estimated all-cause deaths, cancer and CVD deaths respectively to 165, 43 and 38. When comparing mortality in women with and without breast cancer, we found that DM was associated with : all-cause mortality MODERATED POSTER SESSION
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