CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 57 AFRICA Submission ID: 1691 ASSESSMENT OF LEFT DIASTOLIC FUNCTION IN PATIENTS WITH METABOLIC SYNDROME HANANE CHOUKRANI, ANASS MAAROUFI, SARA ABOURADI, RACHIDA HABBAL MOROCCO Background: There are several definitions of metabolic syndrome, but it is most commonly diagnosed when ≥ 3 of the following criteria are present: excess abdominal fat , high fasting blood glucose, hypertension, high triglycerides , low HDL cholesterol. The incidence of metabolic syndrome often parallels that of obesity and type 2 diabetes. It is very common; in the United States, > 40% of people > 50 years of age may have metabolic syndrome. The aim of this study was to assess left diastolic function by echocardiographic parameters in patients with metabolic syndrome without known cardiovascular disease. This study included 125 people who were divided into two groups with a similar mean age, a group with metabolic syndrome n=60 with an age: 63+/-1.7 years and a group without metabolic syndrome n=65, age: 60+/-2.3 years). Left ventricular wall thickness, LV mass were calculated according to the TM mode. The ejection fraction was calculated in simpson biplane. LV diastolic function was assessed by fast filling rate (E-rate), atrial systolic rate (A-rate), and E/A ratio by analyzing the transmitral flow. The Tei index, which reflects both diastolic and systolic LV function, was also calculated. In the metabolic syndrome group, LV wall thickness and LV mass were higher (p<0.001), there was no significant difference in LVEF between the two groups. However, mitral flow parameters and Tei were significantly different between the metabolic syndrome (0.64+/-0.12 and 0.39+/-0.06, respectively) and non-metabolic syndrome groups (0.9+/-0.23 and 0.28+/-0.07) (p<0.001), independent of the presence of LV hypertrophy. These results indicate that the metabolic syndrome is related to the presence of diastolic cardiac dysfunction independently of LV hypertrophy and systolic dysfunction. Submission ID: 1694 PULSE PRESSURE IS A PREDICTIVE TOOL OF CARDIOVASCULAR EVENTS IN TUNISIAN HYPERTENSIVE PATIENTS SAOUSSEN ANTIT, BADREDDINE BEN KAAB, FEKIH RIDHA, AMINE BOUFARES, CYRINE ANTIT, LHEM BOUSSABAH, MOEZ THAMEUR, LILIA ZAKHAMA TUNISIA Introduction: Pulse pressure (PP) reflects the level of arterial stiffness in great vessels. We aimed to confirm that pulse pressure predicted the onset of cardiovascular events. Methods: This is a prospective descriptive study that included 240 hypertensive patients, treated in the outpatient clinic of the Internal Security Forces Hospital in La Marsa, having consulted between 2015 and 2016 and followed for five years. of 61% compared to isolated hypertension. The less than frequent non-dipper character was more associated with cardiovascular events in 75% of cases in our study. Conclusion: Hypertension associated with cardiovascular risks potentiates the occurrence of cardiovascular events even more when it has a nondipper character. Results: The mean age was 57.4±9.5 years, with a sex ratio of 1.3. Diabetes and hypertension were the most common cardiovascular risk factors. Diabetes and dyslipidemia were associated with an increase in pulse pressure but not significantly (p = 0.07 and 0.22 respectively). A significant increase in pulse pressure was noted when moving from the younger group of patients to the older one (p=0.01). On univariate analysis, a significant correlation was observed between pulse pressure, acute coronary syndrome (ACS) (p = 0.01) and heart failure (HF) (p = 0.04). A cutoff value of 60 of PP was obtained to predict the onset of global cardiovascular events with a significant correlation (p = 0.01). On multivariate analysis, a significant correlation was observed between pulse PP, ACS (p = 0.01), HF (p <0.01), stroke (p <0.01) and o global cardiovascular events (p = 0.02). Conclusion: The increase of PP, as measured by ambulatory blood pressure measurements (ABPM), is a predictor of cardiovascular events in a Tunisian treated hypertensive population. Submission ID: 1695 AMBULATORY BLOOD PRESSURE MEASUREMENT: PROFILE AND CORRELATION WITH CARDIOVASCULAR EVENTS IN TREATED HYPERTENSIVE PATIENTS SAOUSSEN ANTIT, BADREDDINE BEN KAAB, RIDHA FEKIH, AMINE BOUFARES, CYRINE ANTIT, MOEZ THAMEUR, ELHEM BOUSSABAH, LILIA ZAKHAMA TUNISIA Background: Cardiovascular risk is directly correlated to the circadian blood pressure profile. The aim of this work was to analyze the profile of Ambulatory blood pressure measurement (ABPM) in treated hypertensive patients as well as evaluate the incidence of cardiovascular events over the medium term, in order to study the ABPM parameters that can predict the occurrence of cardiovascular events. Methods: We conducted a prospective descriptive study of 240 hypertensive patients who were treated and who had had ABPM during their follow-up at our Cardiology Department, with consultations between 2015 and 2016. Results: The mean age of our population was 57.4 ± 9.54 years, with a sex ratio of 1.33. Diabetes was the most common risk factor associated with hypertension (42.1%), followed by obesity (39.2%). This is a high cardiovascular risk population with 61% of patients with 3 or more risk factors and 56.9% with high and very high risk according to the SCORE score. The MAPA analysis showed that the mean 24-hour SSP was 129.5 ± 14 mmHg and the mean 24-hour MAP was 74.7± 9.8 mmHg. Electrical HVG was found in 7.2% of patients. Microalbuminuria was documented in 31.5% of patients and proteinuria in 6.8% of patients. Forty-three cardiovascular events were identified during the 4-year follow-up of our patients with a mean time to onset of 14.5 ± 9 months. In univariate analysis, there was a significant difference between patients with and without a cardiovascular event in terms of age (p=0.026), mean SBP both overall (p=0.011), diurnal (p=0.042) and nocturnal (p=0.005), maximum DBP (p=0.035) and PP (p=0.001). In multivariate analysis, the independent factors associated with cardiovascular events were mean nocturnal SBP (OR=1.04; CI=1.01-1.07; p=0.001) and maximum DBP (OR=0.96; CI=0.920.99; p=0.02). Conclusion: ABPM is an interesting prognostic tool in hypertensive patients, allowing the prediction of long-term cardiovascular events. MODERATED POSTER SESSION
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