Cardiovascular Journal of Africa: Vol 23 No 9 (October 2012) - page 16

CARDIOVASCULAR JOURNAL OF AFRICA • Vol 23, No 9, October 2012 486 AFRICA
Stenting decreased the pulse-delay index from 8.11 ± 3.36 to
3.19 ± 1.78 (p < 0.001). Additionally, significant reductions were
noted in the EDV (pAb < 0.001, pDs < 0.001), LDV (pAb = 0.002,
pDs < 0.001), AT (pAb < 0.001, pDs = 0.020), PHT (pAb < 0.001,
TABLE 2. DOPPLER ECHOCARDIOGRAPHIC PROFILE OFABDOMINALAND DESCENDINGAORTA
BEFOREANDAFTER STENTING (IN PERCENTAGE CHANGE COLUMN, POSITIVEVALUES SHOW
REDUCTIONWHEREAS NEGATIVES SHOW INCREASE INVALUESAFTER STENTING)
Doppler echocardiographic profile
Mean values before stenting Mean values after stenting Mean percentage change after stenting (%)
Abdominal
aorta
Descending
aorta
Abdominal
aorta
Descending
aorta
Abdominal
aorta p-value
Descending
aorta p-value
PSV (m/s) 0.58 ± 0.13 3.84 ± 0.77 0.77 ± 0.20 2.41 ± 0.51 –37.60 ± 35.37 < 0.001 34.88 ± 18.83 < 0.001
EDV (m/s) 0.42 ± 0.15 1.93 ± 0.67 0.21 ± 0.10 0.56 ± 0.33 44.76 ± 32.92 < 0.001 65.04 ± 29.45 < 0.001
LDV (m/s) 0.27 ± 0.09 0.87 ± 0.51 0.19 ± 0.07 0.29 ± 0.14 22.83 ± 32.91 0.002 61.45 ± 27.27 < 0.001
AT (m/s) 229.07 ± 75.48 101.30 ± 56.11 102.14 ± 34.47 68.99 ± 26.32 50.35 ± 23.33 < 0.001 12.45 ± 64.18 0.020
PHT (m/s) 196.39 ± 91.86 163.68 ± 82.72 61.00 ± 19.54 57.26 ± 27.24 59.51 ± 29.14 < 0.001 48.50 ± 62.49 < 0.001
Mean velocity (m/s) 0.38 ± 0.10 1.86 ± 0.45 0.35 ± 0.10 0.96 ± 0.24 1.00 ± 35.74 < 0.001 45.15 ± 21.28 < 0.001
Mean PG 0.69 ± 0.33 19.81 ± 7.96 0.70 ± 0.44 6.58 ± 3.08 –26.95 ± 86.39 0.932 57.81 ± 36.62 < 0.001
D/S ratio velocity 0.72 ± 0.24 0.50 ± 0.15 0.27 ± 0.13 0.22 ± 0.10 59.68 ± 19.65 < 0.001 48.54 ± 37.37 < 0.001
VTI 31.96 ± 9.41 152.85 ± 56.39 24.02 ± 6.90 58.65 ± 17.59 18.34 ± 33.39 0.005 57.37 ± 19.97 < 0.001
Time to peak systolic velocity (m/s) 370.61 ± 76.40 239.59 ± 43.47 243.35 ± 36.05 203.30 ± 41.56 31.48 ± 17.40 < 0.001 11.00 ± 27.40 0.026
Pulse delay – 8.11 ± 3.36 – 3.19 ± 1.78 – – 54.62 ± 26.91 < 0.001
Pulsatility index – 0.89 ± 0.30 – 1.75 ± 0.51 – – –119.57 ± 110.16 < 0.001
PSV: peak systolic velocity, EDV: early diastolic velocity, LDV: late diastolic velocity, AT: systolic acceleration time, PHT: pressure half-time, PG: peak
gradient, D/S: diastolic velocity/systolic velocity, VTI: velocity time integral.
All p-values are from paired t-test and p < 0.05 is considered significant.
TABLE 3. DIAGNOSTICVALUES OF DIFFERENT CUT-OFF POINTS OF ECHOCARDIOGRAPHIC PROFILES OFABDOMINAL
AND DESCENDINGAORTA TO DIFFERENTIATE SIGNIFICANT COARCTATION (PRE-STENTING CONDITION) FROM POST-
STENTING CONDITION ORWITHOUT COARCTATION (ALL DATA DERIVED FROM ROC CURVEANALYSIS)
Echocardiographic index AUC p-value Cut-off point Sensitivity (%) Specificity (%)
Abdominal aorta
PSV (m/s) 0.816 < 0.001 0.655 73.9 73.9
EDV (m/s) 0.902 < 0.001 0.325 82.6 87
LDV (m/s) 0.747 0.004 0.205 69.6 65.2
AT (m/s) 0.940 < 0.001 131.00
146.50
91.3
82.6
87
91.3
PHT (m/s) 0.960 < 0.001 83.5
106.00
91.3
87
82.6
100
Mean velocity (m/s) 0.616 0.177 - - -
Mean PG 0.560 0.489 - - -
D/S ratio velocity 0.968 < 0.001 0.43 95.7 87
VTI 0.757 0.003 27.5 73.9 69.6
Time to peak systolic velocity (m/s) 0.953 < 0.001 308.5 82.6 100
Descending aorta
PSV (m/s) 0.938 < 0.001 3.09
3.37
90.9
81.8
87
100
EDV (m/s) 0.965 < 0.001 0.96 90.9 87
LDV (m/s) 0.922 < 0.001 0.385 90.9 82.6
AT (m/s) 0.696 0.025 77.43 68.2 69.6
PHT (m/s) 0.900 < 0.001 85.5 81.8 87
Mean velocity (m/s) 0.969 < 0.001 1.18
1.33
95.5
90.9
87
91.3
Mean PG 0.949 < 0.001 10.50 90.9 91.3
D/S ratio velocity 0.931 < 0.001 0.365 81.8 91.3
VTI 0.980 < 0.001 87.50
94.5
90.9
86.4
91.3
100
Time to peak systolic velocity (m/s) 0.698 0.023 242.50 50 91.3
Pulse delay 0.957 < 0.001 5.98 87 95.7
Pulsatility index 0.945 < 0.001 1.21 87 91.3
PSV: peak systolic velocity, EDV: early diastolic velocity, LDV: late diastolic velocity, AT: systolic acceleration time, PHT: pressure half-time, PG: peak
gradient, D/S: diastolic velocity/systolic velocity, VTI: velocity time integral, AUC: area under curve.