CARDIOVASCULAR JOURNAL OF AFRICA • Vol 22, No 3, May/June 2011
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153
cular diseases: part I: general considerations, the epidemiologic transi-
tion, risk factors, and impact of urbanization.
Circulation
2001;
104
:
2746–2753.
74. Walker AR, Sareli P. Coronary heart disease: outlook for Africa.
J R Soc
Med
1997;
90
: 23–27.
75. Ferris WF, Naran NH, Crowther NJ, Rheeder P, van der ML, Chetty
N. The relationship between insulin sensitivity and serum adiponectin
levels in three population groups.
Horm Metab Res
2005;
37
: 695–701.
76. Mbanya JC, Motala AA, Sobngwi E, Assah FK, Enoru ST. Diabetes in
sub-Saharan Africa.
Lancet
2010;
375
: 2254–2266.
77. Ali AT, Crowther NJ. Body fat distribution and insulin resistance.
S Afr
Med J
2005;
95
: 878–880.
78. Van der Merwe M-T, Crowther NJ, Schlaphoff GP, Gray IP, Joffe BI,
Lönnroth PN. Evidence for insulin resistance in black women from
South Africa.
Int J Obes
2000;
24
: 1340–1346.
79. Goedecke JH, Levitt NS, Lambert EV, Utzschneider KM, Faulenbach
MV, Dave JA,
et al
. Differential effects of abdominal adipose tissue
distribution on insulin sensitivity in black and white South African
women.
Obesity
2009;
17
: 1506–1512.
80. Crowther NJ, Ferris WF, Ojwang PJ, Rheeder P. The effect of abdominal
obesity on insulin sensitivity and serum lipid and cytokine concentra-
tions in African women.
Clin Endocrinol
(Oxf)
2006;
64
: 535–541.
81. Walker AR, Walker BF, Manetsi B, Tsotetsi NG, Walker AJ. Obesity in
black women in Soweto, South Africa: minimal effects on hypertension,
hyperlipidaemia and hyperglycaemia.
J R Soc Hlth
1990;
110
: 101–103.
82. Ali AT, Crowther NJ. The relationship between national socio-econom-
ic variables and obesity prevalence rates in Africa and Europe.
J
Endocrinol Metab Diabetes S Afr
2010;
15
: 29.
83. Eckel RH. Insulin resistance: an adaptation for weight maintenance.
Lancet
1992;
340
: 1452–1453.
84. Swinburn BA, Nyomba BL, Saad MF, Zurlo F, Raz I, Knowler WC,
et
al
. Insulin resistance associated with lower rates of weight gain in Pima
Indians.
J Clin Invest
1991;
88
: 168–173.
85. Frayn KN, Humphreys SM, Coppack SW. Net carbon flux across
subcutaneous adipose tissue after a standard meal in normal-weight and
insulin-resistant obese subjects.
Int J Obes Relat Metab Disord
1996;
20
: 795–800.
86. Pond CM. Adipose tissue and the immune system.
Prostaglandins
Leukot Essent Fatty Acids
2005;
73
: 17–30.
87. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C,
et al
. Beneficial effects of leptin on obesity, T cell hyporesponsiveness,
and neuroendocrine/metabolic dysfunction of human congenital leptin
deficiency.
J Clin Invest
2002;
110
: 1093–1103.
88. Young C, Jarrell BE, Hoying JB, Williams SK. A porcine model for
adipose tissue-derived endothelial cell transplantation.
Cell Transpl
1992;
1
: 293–298.
89. Tholpady SS, Llull R, Ogle RC, Rubin JP, Futrell JW, Katz AJ. Adipose
tissue: stem cells and beyond.
Clin Plast Surg
2006;
33
: 55–62.
90. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H,
et al
.
Human adipose tissue is a source of multipotent stem cells.
Mol Biol
Cell
2002;
13
: 4279–4295.
91. Wickham MQ, Erickson GR, Gimble JM, Vail TP, Guilak F. Multipotent
stromal cells derived from the infrapatellar fat pad of the knee.
Clin
Orthop Relat Res
2003;
412
: 196–212.
92. Gimble J, Guilak F. Adipose-derived adult stem cells: isolation, charac-
terization, and differentiation potential.
Cytotherapy
2003;
5
: 362–369.
93. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ,
et al
.
Multilineage cells from human adipose tissue: implications for cell-
based therapies.
Tissue Eng
2001; 7: 211–228.
94. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble
JM. Surface protein characterization of human adipose tissue-derived
stromal cells.
J Cell Physiol
2001;
189
: 54–63.
95. Gimble JM, Guilak F. Differentiation potential of adipose derived adult
stem (ADAS) cells.
Curr Top Dev Biol
2003;
58
: 137–160.
96. Rangappa S, Fen C, Lee EH, Bongso A, Sim EK. Transformation of
adult mesenchymal stem cells isolated from the fatty tissue into cardio-
myocytes.
Ann Thorac Surg
2003;
75
: 775–779.
97. Sommer B, Sattler G. Current concepts of fat graft survival: histology
of aspirated adipose tissue and review of the literature.
Dermatol Surg
2000;
26
: 1159–1166.
98. Kwan MD, Slater BJ, Wan DC, Longaker MT. Cell-based therapies for
skeletal regenerative medicine.
Hum Mol Genet
2008;
17
: R93–R98.
99. Slater BJ, Kwan MD, Gupta DM, Panetta NJ, Longaker MT.
Mesenchymal cells for skeletal tissue engineering.
Expert Opin Biol
Ther
2008;
8
: 885–893.
100. Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI, Helder
MN. Adipose stem cells for intervertebral disc regeneration: current
status and concepts for the future.
J Cell Mol Med
2008;
12
: 2205–2216.
101. Smaldone MC, Chen ML, Chancellor MB. Stem cell therapy for
urethral sphincter regeneration.
Minerva Urol Nefrol
2009;
61
: 27–40.
102. Nathan S, Das DS, Thambyah A, Fen C, Goh J, Lee EH. Cell-based
therapy in the repair of osteochondral defects: a novel use for adipose
tissue.
Tissue Eng
2003;
9
: 733–744.
103. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ,
Bovenkerk JE,
et al
. Secretion of angiogenic and antiapoptotic factors
by human adipose stromal cells.
Circulation
2004;
109
: 1292–1298.
104. Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose
tissue-derived stem cells differentiate into endothelial cells
in vitro
and
improve postnatal neovascularization
in vivo. Biochem Biophys Res
Commun
2005;
332
: 370–379.
105. Murohara T, Shintani S, Kondo K. Autologous adipose-derived regen-
erative cells for therapeutic angiogenesis
. Curr Pharm Des
2009;
15
:
2784–2790.
106. Rigotti G, Marchi A, Galie M, Baroni G, Benati D, Krampera M,
et al
.
Clinical treatment of radiotherapy tissue damage by lipoaspirate trans-
plant: a healing process mediated by adipose-derived adult stem cells.
Plast Reconstr Surg
2007;
119
: 1409–1422.
107. KimWS, Park BS, Sung JH. The wound-healing and antioxidant effects
of adipose-derived stem cells.
Expert Opin Biol Ther
2009;
9
: 879–887.
108. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis
of mesenchymal stem cells from bone marrow, umbilical cord blood, or
adipose tissue.
Stem Cells
2006;
24
: 1294–1301.
109. Brey EM, Patrick CW, Jr. Tissue engineering applied to reconstructive
surgery.
IEEE Eng Med Biol Mag
2000;
19
: 122–125.
110. Stosich MS, Mao JJ. Adipose tissue engineering from human adult stem
cells: clinical implications in plastic and reconstructive surgery.
Plast
Reconstr Surg
2007; 119: 71-83.
111. Parker AM, Katz AJ. Adipose-derived stem cells for the regeneration of
damaged tissues.
Expert Opin Biol Ther
2006;
6
: 567–578.
112. Stosich MS, Bastian B, Marion NW, Clark PA, Reilly G, Mao JJ.
Vascularized adipose tissue grafts from human mesenchymal stem cells
with bioactive cues and microchannel conduits.
Tissue Eng
2007;
13
:
2881–2890.
113. Halberstadt C, Austin C, Rowley J, Culberson C, Loebsack A, Wyatt
S,
et al
. A hydrogel material for plastic and reconstructive applications
injected into the subcutaneous space of a sheep.
Tissue Eng
2002;
8
:
309–319.
114. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI,
Castle AL,
et al
. Surgical implantation of adipose tissue reverses diabe-
tes in lipoatrophic mice.
J Clin Invest
2000;
105
: 271–278.
115. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ,
et al
.
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin
resistance in patients receiving HIV protease inhibitors.
AIDS
1998;
12
: F51–F58.
116. Davison SP, Timpone J, Jr., Hannan CM. Surgical algorithm for
management of HIV lipodystrophy.
Plast Reconstr Surg
2007;
120
:
1843–1858.
117. Aust L, Devlin B, Foster SJ, Halvorsen YD, Hicok K, du LT et al. Yield
of human adipose-derived adult stem cells from liposuction aspirates.
Cytotherapy
2004;
6
: 7–14.
118. Kim DH, Je CM, Sin JY, Jung JS. Effect of partial hepatectomy on in
vivo engraftment after intravenous administration of human adipose
tissue stromal cells in mouse.
Microsurgery
2003;
23
: 424–431.
119. Lee JA, Parrett BM, Conejero JA, Laser J, Chen J, Kogon AJ,
et al
.
Biological alchemy: engineering bone and fat from fat-derived stem
cells.
Ann Plast Surg
2003;
50
: 610–617.
120. Cowan CM, Shi YY, Aalami OO, Chou YF, Mari C, Thomas R,
et al
.
Adipose-derived adult stromal cells heal critical-size mouse calvarial
