Cardiovascular Journal of Africa: Vol 24 No 8 (September 2013) - page 12

CARDIOVASCULAR JOURNAL OF AFRICA • Vol 24, No 8, September 2013
302
AFRICA
Conclusion
Fish oil supplementation is a useful tool to increase the
dietary intake of n-3 essential fatty acids. However, due to the
absence of a food supplement regulatory structure in South
Africa, there is concern about the safety, purity and quality of
the fish oil supplements surveyed. This analysis has shown a
small improvement in the accuracy of EPA content declared
on supplement labels compared to the 2009 survey. It was also
evident that a higher percentage of supplements contained DHA
levels higher than declared.
Fish oil supplements remain expensive and are deemed to
be unaffordable for the majority of South African consumers. A
relatively large number of supplements were found to be in the
early stages of rancidity. Of greater concern was the peroxide
(rancidity) level of more than 80% of supplements, which were
higher than the recommended content as specified by GOED.
17
Dietary intakes of oxidised fatty acids may pose deleterious
health effects.
Compared to the previous survey, it seems that manufacturers
have increased the DHA-to-EPA ratio as well as the concentration
of these two components. Some of the surveyed supplements
had EPA and DHA contents much higher than the standard 180
mg EPA and 120 mg DHA per 1 000 mg fish oil. This can be
attributed to the EE and/or rTG content of these preparations.
The safety of EE and rTG has not been confirmed in humans.
The authors thank Mr Alfred Hlabana from the CPUT Functional Foods
Research Unit for his assistance in analysing the fish oil supplement samples
and the South African Cancer Association (CANSA) for financial support to
conduct the survey.
References
1.
Calzolari I, Fumagalli S, Marchionni N, Di Bari M,
et al.
Polyunsaturated
fatty acids and cardiovascular disease.
Curr Pharm Des
2009;
15
(36):
4094–4102.
2.
Calder PC. Fatty acids and inflammation: The cutting edge between
food and pharma.
Eur J Pharmacol
2011;
668
: S50–58.
3.
Birch EE, Carlson SE, Hoffman DR, Fitzgerald-Gustafson KM, Fu
VL, Drover JR, Castañeda YS,
et al.
The DIAMOND (DHA Intake
And Measurement Of Neural Development) study: a double-masked,
randomized controlled clinical trial of the maturation of infant visual
acuity as a function of the dietary level of docosahexaenoic acid
. Am J
Clin Nutr
2010;
91
(4): 848–859.
4.
DeFilippis AP and Sperling LS. Understanding omega-3s.
Am Heart J
2006
;
151
:564–570.
5.
Opperman AM, Marais DW, Benadé AJS. Washout kinetics of eicosa-
pentanoic and docosahexanoic acid from human plasma after supple-
mentation with salmon oil.
S Afr J Clin Nutr
2010;
29
: S8.
6.
Harris WS. Omega-3 fatty acids and cardiovascular disease: a case
for omega-3 index as a new risk factor.
Pharmacol Res
2007;
55
(3):
217–223.
7.
Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association
between omega-3 fatty acid supplementation and risk of major cardio-
vascular disease events: a systematic review and meta-analysis.
J Am
Med Assoc
2012;
308
(10): 1024–1033.
8.
Kwak SM, Myung SK, Lee YJ, Seo HG; Korean Meta-analysis Study
Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic
acid and docosahexaenoic acid) in the secondary prevention of cardio-
vascular disease: a meta-analysis of randomized, double-blind, placebo-
controlled trials.
Arch Intern Med
2012;
172
(9): 686–694.
9.
Jump DB, Depner CM, Tripathy S. Omega-3 fatty acid supplementation
and cardiovascular disease.
J Lipid Res
. jlr.R027904. First Published on
August 17, 2012.
10. Marik PE, Varon J. Omega-3 dietary supplements and the risk of
cardiovascular events: a systematic review.
Clin Cardiol
2009;
32
(7):
365–372.
11. Aranceta J, Pérez-Rodrigo C. Recommended dietary reference intakes,
nutritional goals and dietary guidelines for fat and fatty acids: a system-
atic review.
Br J Nutr
2012;
107
Suppl 2: S8–22.
12. International Society for the Study of Fatty Acids and Lipids.
Recommendations for the intake of polyunsaturated fatty acids in
healthy adults. 2004.
/ (accessed 12 December
2012).
13. Opperman AM, Marais DW, Benadé AJS. Analysis of omega-3 fatty
acid content of South African fish oil supplements
. Cardiovasc J Afr
2011;
22
: 324–329.
14. Recknagel RO, Glende EA. Spectrophotometric detection of lipid
conjugated dienes.
Meth Enzymol
1984;
105
: 331–337.
15. Khodaparast MHH, Haghdoost A and Movahhed GG. New source of
butein in root of
Salvia leriifolia
(Nowroozak).
J Agric Environ Sci
2008;
4
(6): 731–736.
16. Benadé AJ, Fincham JE, Smuts CM, Tung MT, Chalton D, Kruger M,
et al
. Plasma low density lipoprotein composition in relation to athero-
sclerosis in nutritionally defined Vervet monkeys.
Atherosclerosis
1988;
74
(1–2): 157–168.
17. Global Organization for EPA and DHA Omega-3. 2012. GOED volun-
tary monograph (v. 4).
[15 February
2013].
18. Food and Drug Administration. New Dietary Ingredients in Dietary
Supplements – Background for Industry. FDA. [10 March 2013].
19. European Union’s Food Supplements Directive. Directive 2002/46/EC
of the European Parliament and of the Council of 10 June 2002 on the
approximation of the laws of the Member States relating to food supple-
ments. [10 March 2013].
20. Turner R, McLean CH, Silvers KM. Are the health benefits of fish oils
limited by products of oxidation?
Nutr Res Rev
2006;
19
(1): 53–62.
21. Spiteller G. The relation of lipid peroxidation processes with atherogen-
esis: a new theory on atherogenesis.
Mol Nutr Food Res
2005;
49
(11):
999–1013.
22. Penumetcha M, Khan N, Parthasarathy S. Dietary oxidized fatty acids:
an atherogenic risk?
J Lipid Res
2000;
41
(9): 1473–1480.
23. Staprans I, Pan XM, Rapp JH, Feingold KR. The role of dietary
oxidized cholesterol and oxidized fatty acids in the development of
atherosclerosis.
Mol Nutr Food Res
2005;
49
(11): 1075–1082.
24. Yoerger DM, Best CA, McQuillan BM, Supple GE, Guererro JL,
Cluette-Brown JE, Hasaba A, Picard MH, Stone JR, Laposata M. Rapid
fatty acid ethyl ester synthesis by porcine myocardium upon ethanol
infusion into the left anterior descending coronary artery.
Am J Pathol
2006;
168
: 1435–1442.
25. Alhomsi K, Selig M, Sustic T, Katrangi E, Weissig V, Laposata M.
Induction of apoptosis and necrosis in human peripheral blood mono-
nuclear cells by fatty acid ethyl esters.
Alcohol Clin Exp Res
2008;
32
:
534–543.
26. Bearer CF, Gould S, Emerson R, Kinnunen P, Cook CS. Fetal alcohol
syndrome and fatty acid ethyl esters.
Pediatr Res
1992;
31
: 492–495.
27. Saghir M, Werner J, Laposata M. Rapid
in vivo
hydrolysis of fatty acid
ethyl esters, toxic nonoxidative ethanol metabolites.
Am J Physiol
1997;
273
: G184–190.
28. Lopez-Huertas E. The effect of EPA and DHA on metabolic syndrome
patients: a systematic review of randomised controlled trials.
Br J Nutr
2012;
107
: S185–194.
29. Mori TA, Burke V, Puddey IB,
et al.
Purified eicsapentaenoic and doco-
sahexaenoic acids have differential effects on serum lipids and lipopro-
teins, LDL particle size, glucose, and insulin in mildly hyperlipidemic
men.
Am J Clin Nutr
2000;
71
: 1085–1094.
30. Griffin MD, Sanders TA, Davies IG,
et al.
Effects of altering the ratio of
dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and
postprandial lipemia in men and postmenopausal women aged 45-70 y:
the OPTILIP Study.
Am J Clin Nutr
2006;
84
: 1290–1298.
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