CARDIOVASCULAR JOURNAL OF AFRICA • Volume 26, No 1, January/February 2015
12
AFRICA
Conclusion
We evaluated aortic stiffness parameters in childhood-onset
asthma in children with a diagnosis of asthma of at least three
years’ duration (average duration from diagnosis: 8.1
±
2.8
years). We did not find any difference between chidhood-onset
asthma patients and the control group with regard to aortic
stiffness parameters (DIS, S, Ep and Ep*). There was also no
difference in these parameters when we compared patients with
mild asthma and those with moderate asthma. These results may
be due to the anti-inflammatory effect of inhaled corticosteroid
treatment.
Since there is no study in the literature evaluating abdominal
aortic stiffness in childhood-onset asthma patients, we could
not compare our results with other studies. Further studies are
needed to validate these results.
References
1.
Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic
inflammatory phenotype is associated with systemic inflammation in
asthma.
Chest
2012;
142
: 86–93.
2.
Michelson PH, Williams LW, Benjamin DK, Barnato AE. Obesity.
inflammation. and asthma severity in childhood: data from the National
Health and Nutrition Examination Survey 2001–2004.
Ann Allergy
Asthma Immunol
2009;
103
: 381–385.
3.
Deraz TE, Kamel TB, El-Kerdany TA, El-Ghazoly HM. High-sensitivity
C reactive protein as a biomarker for grading of childhood asthma in
relation to clinical classification. induced sputum cellularity. and spirom-
etry.
Pediatr Pulmonol
2012;
47
: 220–225.
4.
Sattar N. Inflammation and endothelial dysfunction: intimate compan-
ions in the pathogenesis of vascular disease?
Clin Sci
2004; 106: 443–445.
5.
Safar ME, Blacher J, Jankowski P. Arterial stiffness. pulse pressure.
and cardiovascular disease-is it possible to break the vicious circle.
Atherosclerosis
2011;
218
: 263–271.
6.
Agarwal SK, Heiss G, Barr RG, Chang PP, Loehr LR, Chambless LE,
et
al
. Airflow obstruction. lung function. and risk of incident heart failure:
the Atherosclerosis Risk in Communities (ARIC) study.
Eur J Heart Fail
2012;
14
: 414–422.
7.
Iribarren C, Tolstykh IV, Miller MK, Sobel E, Eisner MD. Adult
asthma and risk of coronary heart disease. cerebrovascular disease. and
heart failure: a prospective study of 2 matched cohorts.
Am J Epidemiol
2012;
176
: 1014–1024.
8.
Jacobs Jr DR, Yatsuya H, Hearst MO, Thyagarajan B, Kalhan R,
Rosenberg S,
et al
. Rate of decline of forced vital capacity predicts
future arterial hypertension: the coronary artery risk development in
young adults study.
Hypertension
2012;
59
: 219–225.
9.
Majoor CJ, Kamphuisen PW, Zwinderman AH, Ten Brinke A, Amelink
M, Rijssenbeek-Nouwens L,
et al
. Risk of deep vein thrombosis and
pulmonary embolism in asthma.
Eur Respir J
2013;
42
: 655–661.
10. Lacombe F, Dart A, Dewar E, Jennings G, Cameron J, Laufer E.
Arterial elastic properties in man: A comparison of echo-Doppler indi-
ces of aortic stiffness
. Eur Heart J
1992;
13
: 1040–1045.
11. Okubo M, Ino T, Tkahashi K, Kishiro M, Akimoto K, Yamashiro Y.
Age dependency of stiffness of the abdominal aorta and the mechanical
properties of the aorta in Kawasaki disease in children.
Pediatr Cardiol
2001;
22
: 198–203.
12. Levent E, Ozyürek AR, Ulger Z. Evaluation of aortic stiffness in tobac-
co-smoking adolescents.
J Adolesc Health
2004;
34
: 339–343.
13. Levent E, Gökşen D, Ozyürek AR. Stiffness of the abdominal aorta in
obese children.
J Pediatr Endocrinol Metab
2002;
15
: 405–409.
14. Ulger Z, Aydinok Y, Gurses D, Levent E, Ozyurek AR. Stiffness of the
abdominal aorta in beta-thalassemia major patients related with body
iron load.
J Pediatr Hematol Oncol
2006;
28
: 647–652.
15. Lage SG, Kopel L. Arterial elastic properties: Comparison of results
and units.
J Am Coll Cardiol
1992;
20
: 1046–1047.
16. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald
M,
et al
. Global strategy for asthma management and prevention:
GINA executive summary.
Eur Respir J
2008;
31
: 143–178.
17. Sahn DJ, DeMaria A, Kisslo J, Weyman A. The committee on M-mode
standardization of the American Society of Echocardiography. Results
of a survey of echocardiographic measurements.
Circulation
1978;
58
:
1072–1083.
18. Sattar N. Inflammation and endothelial dysfunction: intimate compan-
ions in the pathogenesis of vascular disease?
Clin Sci
2004;
106
: 443–445.
19. Iribarren C, Tolstykh IV, Eisner MD. Are patients with asthma at
increased risk of coronary heart disease?
Int J Epidemiol
2004;
33
:
743–748.
20. Schanen JG, Iribarren C, Shahar E, Punjabi NM, Rich SS, Sorlie PD.
et
al
. Asthma and incident cardiovascular disease: the Atherosclerosis Risk
in Communities Study.
Thorax
2005;
60
: 633–638.
21. Vignola AM, Chanez P, Campbell AM, Souques F, Lebel B, Enander
I,
et al
. Airway inflammation in mild intermittent and in persistent
asthma.
Am J Respir Crit Care Med
1998;
157
: 403–409.
22. Grisham MB, Jourd’heuil D, Wink DA. Chronic inflammation and
reactive oxygen and nitrogen metabolism implications in DNA damage
and mutagenesis.
Aliment Pharmacol Ther
2000;
14
: 3–9.
23. Libby P. Inflammation in atherosclerosis.
Nature
2002: 868–874.
24. Mahmud A, Feely J. Arterial stiffness is related to systemic inflamma-
tion in essential hypertension.
Hypertension
2005;
46
: 1118–1122.
25. Onufrak S, Abramson J, Vaccarino V. Adult-onset asthma is associ-
ated with increased carotid atherosclerosis among women in the
Atherosclerosis Risk in Communities (ARIC) study.
Atherosclerosis
2007;
195
: 129–137.
26. Otsuki M, Miyatake A, Fujita K, Hamasaki T, Kasayama S. Reduced
carotid atherosclerosis in asthmatic patients treated with inhaled corti-
costeroids.
Eur Respir J
2010;
36
: 503–508.
27. Weiler Z, Zeldin Y, Magen E, Zamir D, Kidon MI. Pulmonary function
correlates with arterial stiffness in asthmatic patients.
Respir Med
2010;
104
: 197–203.
28. Sun WX, Jin D, Li Y, Wang RT. Increased arterial stiffness in stable and
severe asthma.
Respir Med
2014;
108
: 57–62.
29. Cakmak A, Zeyrek D, Cece H, Erel O. The relationship between carotid
intima-media thickness and oxidative stress in asthmatic children.
Asian
Pac J Allergy Immunol
2010;
28
: 256–261.