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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 27, No 1, January/February 2016
20
AFRICA
PR interval, was significantly higher among SCA children with
ECG abnormalities in this study. Studies have shown that elevated
triglyceride levels independently predicted the development of
coronary artery disease and myocardial infarction.
23
Also, it was
reported recently that an elevated level of triglycerides, which is
already known to be linked with endothelial dysfunction, is an
independent predictor of pulmonary hypertesion in patients with
SCA.
29
Raised triglyceride levels is an important cardiovascular
risk factor for atherogenesis, as other abnormalities of the
lipid profile are much more likely and are a readily available
complement to atheromatous plaque formation and progression.
Our study was limited by the small sample size, which
may have affected proper data interpretation and the overall
generalisability of the findings. Also, fasting samples for lipid
estimations were not taken. However, non-fasting lipid levels
have been significantly correlated with fasting triglyceride levels,
and there is new evidence to show that triglyceride levels
measured in the fasting or non-fasting state are important in
determining the prognosis of cardiovascular diseases.
Conclusion
This study showed that lipid and electrocardiographic
abnormalities were common among the children with SCA
attending the paediatric out-patient clinic of WGH, Ilesa, and
they were closely related to the cardiovascular risk of these
patients.
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