CARDIOVASCULAR JOURNAL OF AFRICA • Volume 28, No 5, September/October 2017
AFRICA
303
Inhibition of proliferation and induction of autophagy by atorvastatin
in PC3 prostate cancer cells correlate with downregulation of Bcl2 and
upregulation of miR-182 and p21.
PloS One
2013;
8
(8): e70442.
10. Besbes S, Mirshahi M, Pocard M, Billard C. New dimension in
therapeutic targeting of Bcl-2 family proteins.
Oncotarget
2015;
6
(15):
12862–12871.
11. Lindstrom R, Lindholm P, Kallijarvi J, Palgi M, Saarma M, Heino
TI. Exploring the conserved role of MANF in the Unfolded protein
response in
Drosophila melanogaster. PloS One
2016;
11
(3):e0151550.
12. Xi Y, Shen W, Ma L, Zhao M, Zheng J, Bu S,
et al
. HMGA2
promotes adipogenesis by activating C/EBPbeta-mediated expression
of PPARgamma.
Bioch Biophys Res Commun
2016;
472
(4): 617–623.
13. Anilkumar U, Prehn JH. Anti-apoptotic Bcl-2 family proteins in acute
neural injury. Frontiers Cellr Neurosci 2014;
8
: 281.
14. Van Vre EA, Ait-Oufella H, Tedgui A, Mallat Z. Apoptotic cell death
and efferocytosis in atherosclerosis.
Arterioscler Thromb Vasc Biol
2012;
32
(4): 887–893
15. Yang J, Pan Y, Li X, Wang X. Atorvastatin attenuates cognitive deficits
through Akt1/caspase-3 signaling pathway in ischemic stroke.
Brain Res
2015;
1629
: 231–239.
16. Kutuk O, Basaga H. Bcl-2 protein family: implications in vascular apop-
tosis and atherosclerosis.
Apoptosis
2006;
11
(10): 1661–1675.
17. Rodrigues Diez R, Rodrigues-Diez R, Lavoz C, Rayego-Mateos S,
Civantos E, Rodriguez-Vita J,
et al.
Statins inhibit angiotensin II/Smad
pathway and related vascular fibrosis, by a TGF-beta-independent
process.
PloS One
2010;
5
(11): e14145.
18. Hosomi N, Nagai Y, Kohriyama T, Ohtsuki T, Aoki S, Nezu T,
et al
. The
Japan Statin Treatment Against Recurrent Stroke (J-STARS): a multi-
center, randomized, open-label, parallel-group study.
EBioMedicine
2015;
2
(9): 1071–1078.
19. Rutishauser J. The role of statins in clinical medicine – LDL-cholesterol
lowering and beyond.
Swiss Med Weekly
2006;
136
(3–4): 41–49.
20. Sacco RL, Liao JK. Drug Insight: statins and stroke.
Nature Clin Prac
Cardiovasc Med
2005;
2
(11): 576–584.
21. Hu LH, Zhang T, Shao Q, Li DD, Jin SX, Nie P,
et al
. Atorvastatin
suppresses oxidized LDL-induced dendritic cell-like differentiation
of RAW264.7 cells regulated by the p38 MAPK pathway.
Molec Cell
Biochem
2012;
371
(1–2): 105–113.
22. Yang JW, Hu ZP. Neuroprotective effects of atorvastatin against cere-
bral ischemia/reperfusion injury through the inhibition of endoplasmic
reticulum stress.
Neural Regen Res
2015;
10
(8): 1239–1244.
23. Abo El-Khair DM, El-Safti Fel N, Nooh HZ, El-Mehi AE. A compara-
tive study on the effect of high cholesterol diet on the hippocampal CA1
area of adult and aged rats.
Anat Cell Biol
2014;
47
(2): 117–126.
24. Pal S, Ghosh M, Ghosh S, Bhattacharyya S, Sil PC. Atorvastatin
induced hepatic oxidative stress and apoptotic damage via MAPKs,
mitochondria, calpain and caspase12 dependent pathways.
Food Chem
Toxicol
2015;
83
: 36–47.
25. Sanbe T, Tomofuji T, Ekuni D, Azuma T, Irie K, Tamaki N,
et al
.
Vitamin C intake inhibits serum lipid peroxidation and osteoclast differ-
entiation on alveolar bone in rats fed on a high-cholesterol diet.
Arch
Oral Biol
2009;
54
(3): 235–240.
26. Samout N, Bouzenna H, Ettaya A, Elfeki A, Hfaiedh N.
Antihypercholesterolemic effect of
Cleome arabica
L. on high-cholester-
ol diet induced damage in rats.
Exp Clin Sci J
2015;
14
: 791–800.
27. Beason DP, Hsu JE, Marshall SM, McDaniel AL, Temel RE, Abboud
JA,
et al.
Hypercholesterolemia increases supraspinatus tendon stiffness
and elastic modulus across multiple species.
J Shoulder Elbow Surg
2013;
22
(5): 681–686.
28. Ntchapda F, Djedouboum A, Talla E, Sokeng Dongmo S, Nana P,
Adjia H,
et al.
Hypolipidemic and anti-atherogenic effect of aqueous
extract leaves of
Ficus glumosa
(Moraceae) in rats.
Exp Gerontol
2015;
62
: 53–62.
29. Pal S, Sarkar A, Pal PB, Sil PC. Protective effect of arjunolic acid against
atorvastatin induced hepatic and renal pathophysiology via MAPK,
mitochondria and ER dependent pathways.
Biochimie
2015;
112
: 20–34.
30. Zhang L, Cheng L, Wang Q, Zhou D, Wu Z, Shen L,
et al.
Atorvastatin
protects cardiomyocytes from oxidative stress by inhibiting LOX-1
expression and cardiomyocyte apoptosis.
Acta Biochim Biophys Sinica
2015;
47
(3): 174–182.
31. Mason RP, Sherratt SC, Jacob RF. Eicosapentaenoic acid inhibits
oxidation of ApoB-containing lipoprotein particles of different size
in vitro
when administered alone or in combination with atorvastatin
active metabolite compared with other triglyceride-lowering agents.
J
Cardiovasc Pharmacol
2016;
68
(1): 33–40.
32. De la Sierra A, Pinto X, Guijarro C, Miranda JL, Callejo D, Cuervo
J,
et al.
Prevalence, treatment, and control of hypercholesterolemia in
high cardiovascular risk patients: evidences from a systematic literature
review in Spain.
Adv Ther
2015;
32
(10): 944–961.
33. Liang SJ, Zeng DY, Mai XY, Shang JY, Wu QQ, Yuan JN,
et al.
Inhibition of Orai1 store-operated calcium channel prevents foam cell
formation and atherosclerosis.
Arterioscler Thromb Vasc Biol
2016;
36
(4): 618–628.
34. Lin SJ, Hsieh FY, Chen YH, Lin CC, Kuan, II, Wang SH,
et al
.
Atorvastatin induces thrombomodulin expression in the aorta of
cholesterol-fed rabbits and in TNFalpha-treated human aortic endothe-
lial cells.
Histol Histopathol
2009;
24
(9): 1147–1159.
35. Qian J, Keyes KT, Long B, Chen G, Ye Y. Impact of HMG-CoA reduc-
tase inhibition on oxidant-induced injury in human retinal pigment
epithelium cells.
J Cell Biochem
2011;
112
(9): 2480–2489.
36. Chen TL, Zhu GL, He XL, Wang JA, Wang Y, Qi GA. Short-term
pretreatment with atorvastatin attenuates left ventricular dysfunction,
reduces infarct size and apoptosis in acute myocardial infarction rats.
Int J Clin Exp Med
2014;
7
(12): 4799–4808.