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‘Statins are first-line therapy in patients with
hyperlipidaemia because they clearly prevent cardiovascular
events,’ said Dr Robert Boggs, director of outcomes research,
Centre for Observational and Real-world Evidence (CORE)
at Merck. ‘This study demonstrates not only the value of
helping patients adhere to their statin therapy but, in some
cases, the need for additional treatments to get their LDL-C
down to reasonable thresholds.’
Researchers estimated that reducing the LDL-C levels of
the subgroup who were above the threshold could avoid 1
173 cardiovascular disease events. If those patients were given
the necessary treatments to lower their bad cholesterol levels
to the recommended threshold, the reduced risk would save
about $1 455 per person.
This study is fairly unique because researchers were able
to analyse the records of patients from the entire state of
Indiana. Therefore, the results are more representative of
the state’s population and may have greater public health
implications than studies conducted with, for instance,
patients of a single health system.
‘The presence of the health information exchange in
Indiana was a crucial factor in being able to do this study,’
said Dr Titus Schleyer, the first author on the article and
a research scientist at Regenstrief Institute. ‘The Indiana
Network for Patient Care allows us to gather health data
from large numbers of people on an ongoing basis. While
that information is a by-product of going to the doctor, it is
tremendously useful for research.’
This study provides evidence to health insurance agencies
and physicians that there are opportunities to improve care
and reduce the cost of treating cardiovascular events with
more aggressive therapy for bad cholesterol. Schleyer hopes
information from studies like these could eventually be used
to identify populations at risk and help prevent negative
outcomes.
In addition to his appointment as a Regenstrief Institute
investigator, Schleyer is a faculty member of Indiana
University School of Medicine. The study team also included
Dr Siu Hui, Dr Jane Wang, Dr Zuoyi Zhang and Dr Jarod
Baker from Regenstrief Institute.
Source:
Medical Brief 2019