AFRICA CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 32 Submission ID: 1505 PREVALENCE, PREDICTORS AND REAL-WORLD MANAGEMENT OF NSTEMI WITH MULTIVESSEL DISEASES MAAROUFI ANASS, AMMOURI ZAID, BELKOUCHIA SAMI, HABOUBMERIEM, AROUS SALIM, BENOUNA EL GHALI, AZZOUZI LEILA, DRIGHIL ABDENNACER, HABBAL RACHIDA MOROCCO Background: Non-ST elevation myocardial infarction (NSTEMI) has higher postdischarge mortality than ST-elevation myocardial infarction (STEMI). Prognosis worsens in those with multivessel coronary disease (MVD). However, information about the prevalence and extent of MVD in NSTEMI is limited, in turn limiting insights into optimal treatment strategies. This study aimed to define the prevalence and extent of MVD, preferred treatment strategies and the predictors of MVD in a real-world NSTEMI population. Methods: The informatic data of patients admitted with acute coronary syndrome between 2020 and 2022 was used to identify consecutive patients presenting with NSTEMI diagnosis . Based on clinical and angiographic details, patients were categorized by the number of significantly diseased vessels (0,1,2,3-VD), defined by a stenosis of ≥70%, or ≥50% in the left main coronary artery. Data was analysed retrospectively. Results: Among 764 patients admitted for acute coronary syndrome, NSTEMI counted for 331 patients (43.3%), the prevalence of MVD (2- or 3 VD) among them was 27%. Multivariate logistic regression modelling showed age, male gender, diabetes, dyslipidaemia and prior myocardial infarction predicted MVD over 1-VD or 0-VD. Percutaneous coronary intervention (PCI) was performed in 71% of patients with MVD. This comprised 75% of 2-VD patients and only 42 % of 3-VD patients, with 31 % referred for coronary bypass grafting. Among MVD patients treated with PCI, 86% had their culprit lesion treated alone in the index admission. Conclusions: In this NSTEMI cohort, over 27% had MVD. Notably, a minority of patients with MVD undergoing PCI received multivessel revascularisation. This real-world practice emphasises that further evaluation is required to determine whether complete revascularisation is beneficial in NSTEMI, as reported for STEMI. Submission ID: 1506 INFECTIVE ENDOCARDITIS PROFILE, PROGNOSTIC FACTORS AND IN-HOSPITAL MORTALITY: 6-YEAR TRENDS FROM A TERTIARY UNIVERSITY CENTER IN MOROCCO MAAROUFI ANASS, NOEL MASCHELL MAHNOUNGOU, ZAHIDI HATIM, HABOUB MERIEM, AROUS SALIM, BENOUNA EL GHALI, AZZOUZI LEILA, DRIGHIL ABDENNACER, HABBAL RACHIDA MOROCCO Background: Infective endocarditis (IE) stills an serious health problem with high morbimortality rates. Even though it’s present in clinical practice , epidemiological and microbiological data remain scarce, especially in developing countries. Aim: This study aims to describe IE epidemiological, clinical, and microbiological profile in a tertiary university center in Morocco, and to identify in-hospital mortality rate and predictors. Methods: An observational, retrospective study of 122 patients, who fulfilled modified Duke’s criteria during a six-year enrollment period, from January 2017 to June 2022. The primary outcome was defined as in-hospital mortality analyzed according to treatment received (medical or surgical). Multivariate analysis was used to identify mortality predictors. Results: The median age was 40 years (Q1 -Q3 27-51), and 59% were male. Echocardiogram demonstrated vegetations in 75 %. An infective agent was identified in 31%, of culture positive endocarditis Staphylococcus species respresented (32%), Streptococcus (29%) which were the most prevalent. Overall in-hospital mortality was 17%, surgical patients represented only 5% of deceased patients . On multivariate analysis, previous structural heart disease (OR, 3.1), and aortic valve infection (OR, 3.1) were all-cause death predictors. Surgical treatment was the only variable related to a better outcomes (OR, 0.45; 95% Confidence Interval, 0.2-0.9). Conclusion: This study presents IE profile and all-cause mortality in a large patient’s cohort, comprising a 6-years’ time window, a rare initiative in developing countries. male patients predominated, while Staphycocci species were the main microbiological agents. Patients conservatively treated presented higher mortality than surgically managed ones. Epidemiological studies from developing countries are essential to increase IE understanding. Submission ID: 1508 CLINICAL CHARACTERISTICS AND PROGNOSIS OF SURGICAL PATIENTS DUE TO INFECTIVE ENDOCARDITIS AMRI MERIAM, MAAROUFI ANASS, BENNANI GHALI, HABOUB MERYEM, AROUSS SALIM, BENOUNA EL GHALI MOHAMMED, DRIGHIL ABDENASSER, AZZOUZI LEILA, HABBAL RACHIDA MOROCCO Introduction: Infective endocarditis (IE) is a non contagious infection sof the endocardium and heart valves or of a prosthetic valvular implant. It is associated with high mortality. Surgery may improve survival and reduce complications. Background and purpose: We investigated differences in clinical presentation, microbiology, and short- and long-term results according to the affected valve in patients who underwent surgery for left-sided native valve IE. Methodology: This was a single-center retrospective study between 2014 and 2022 of 123 patients who met the Duke criteria for Infective endocarditis diagnosis. 20 patients with isolated mitral valve IE (group M) and 12 patients with isolated aortic valve IE (group A) underwent surgery following diagnosis. Results and discussion: The average age of patients in group M was 41 ± 9 years, whereas in group A the patients were 38 ± 7 years old (p = 0.05). Females accounted for 39 % of patients in group M, whereas they were 27 % of patients in group A (p < 0.001). Abscesses were more common in group A (27%) than in group M (8%). Staphylococcus aureus was more frequent in group M (19%) than in group A (7%; p < 0.05). The duration from symptom onset to diagnosis was longer in group A (mean of 1 month) than in group M (mean of 15 days), but the time from diagnosis to surgery was shorter in group A than in group M. All patients underwent surgery more than 48 hours after diagnosis and 90-day mortality was Higher in group M (10 % versus MODERATED POSTER SESSION
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