CARDIOVASCULAR JOURNAL OF AFRICA • SMC-PAFCIC Abstracts October 2022 33 AFRICA 8 % in group A) (p = 0.06). Average hospital stay in group M was 29 days versus 27 days in group A. Conclusion: There were considerable differences in preoperative characteristics, microbiology, and outcomes between patients who underwent surgery for isolated aortic valve IE and those who were operated for isolated mitral valve IE. Submission ID: 1511 HEART FAILURE IN ENDOCARDITIS PATIENTS: CHARACTERISTICS AND PROGNOSIS AMRI MERIAM, MAAROUFI ANASS, ZAHRI SOUKAINA, HABBOUB MERYEM, AROUSS SALIM, BENOUNA EL GHALI MOHAMMED, DRIGHIL ABDENASSER, AZZOUZI LEILA, HABBAL RACHIDA MOROCCO Background and Objectives: Heart failure (HF) is the most common complication of infective endocarditis. Our aim were to determine the clinical, echocardiographic, and microbiological variables associated with HF in patients with infective endocarditis and to investigate variables associated with in-hospital and 1-year mortality and association of surgery with outcome. Methodology: A retrospective analysis of confirmed cases of Infective Endocarditis (IE) in both native and prosthetic valves, according to Duke Criteria, admitted to a Moroccan tertiary hospital between December 2013 and June 2022. The main outcome measures In-hospital and 1-year mortality. Results and discussion: Out of 123 patients with infective endocarditis and known HF status enrolled, 77 (62%) had Heart Failure, and 46 (38%) were classified as having New York Heart Association class III or IV symptom status. Within the subset with HF, 54 (70%) underwent valvular surgery during the hospitalization duration. In-hospital mortality was 20.9 % for the entire HF cohort, with lower mortality observed in patients undergoing valvular surgery compared with medical therapy alone ((15% vs 47%), respectively; P < 0.05). One-year mortality was 20% in patients undergoing valvular surgery vs 57 % in those not undergoing surgery (P < .05). Cox proportional hazards modeling with propensity score adjustment for surgery showed that advanced age, health care-associated infection, causative microorganism (Staphylococcus aureus or fungi), severe HF (New York Heart Association class III or IV) at admission, stroke, and prosthetic valves were independently associated with 1-year mortality, whereas valvular surgery during the initial hospitalization was associated with lower mortality. Conclusion: In this cohort of patients with infective endocarditis complicated by HF, severity of HF was strongly associated with surgical therapy and subsequent mortality, whereas valvular surgery was associated with lower in-hospital and 1-year mortality. Submission ID: 1516 PULMONARY ARTERIAL HYPERTENSION IN PEDIATRIC CARDIOLOGY EPIDEMIOLOGICAL PROFILE, MANAGEMENT AND SURVIVAL IN TUNISIA GHORBEL CHAYMA, HAKIM KAOUTHAR, BEN OTHMAN RIHAB, NOUHA MEKKI, MSAED HELA, SABRINE SOUDANI, HMAEIR ELEE, ZEREI KARAM, SOULA MOHAMED AMINE, TALHAOUI AMIRA, FATMA OUARDA TUNISIA Background: Pulmonary arterial hypertension (PAH group 1) in pediatric population has a specific etiologies even that it shares common features of adult disease. Children have a greater predominance of idiopathic pulmonary arterial hypertension (IPAH) and pulmonary arterial hypertension (PAH) associated with congenital heart disease (PAH-CHD). Objective: The aim of this work is to identify the epidemiological, clinical, hemodynamic profile of PAH as well as its therapeutic implications in a pediatric cardiology department Methods: To meet our objective, we conducted a descriptive retrospective study of 42 patients who were hospitalized for PAH (group 1 of the European Society of cardiology classification) in the pediatric cardiology department of the University Hospital La Rabta. Results: Our population includes 42 patients with an average age of 22.5 years [5-37], with a female predominance of 66.7%. PAH was idiopathic in 35.7% and was associated with congenital heart disease in 64.28%. The various congenital heart diseases found in our patients were mainly in the form of VSD (ventricular septal defect) (26.19%) followed by complete AVSD (atrioventricular septum defect) in 23.8%. Four cases of PDA (persistent arterial duct) were found (9.52%), one case of UVH (Univentricular Heart) and one case of TA (truncus arteriosis). The most found associated pathology (10.7%) was T21 (trisomy 21). Fifty percent of our patients were asymptomatic at the interrogation (50%). However, the various functional signs reported by the patients were dyspnea in 35.7%, and it was associated with syncope in 4 patients. On cardiac ultrasound, the mean PAPS was 95.87mm Hg [60-180]. At the cardiac catheterization, we found an average hemodynamic PAPm of 76.38mmHg [40-133] and an average PAPS of 104.37mmHg [50-160mmHg]. Medical treatment was put in 73.8% of cases, including 70.96% in the form of bosentan and 16.12% in the form of sildenafil. The clinical evolution was favorable in 7.1%, on the other hand a persistence of dyspnea is found in 6% of the cases, only one case developed heart failure and 7.1% were lost to follow-up. Six patients were died Conclusion: The field of pediatric PH still needs specific clinical trials to develop specific treatment strategies. Faced with the gravity of the prognosis of PAH in children, it is necessary, on the one hand, to insist on the marketing of specific treatment for PAH which are not yet available in our country. On the other hand, we must try to speed up surgical procedures so as to no longer have forms of PAH attached to potentially curable pathologies. MODERATED POSTER SESSION
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