CARDIOVASCULAR JOURNAL OF AFRICA • Volume 29, No 6, November/December 2018
AFRICA
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by the same physician, and there was a lack of inter-observer
variability. Lastly, manual measurement of the Tp-e and Tp-e/
QT interval may be less reliable than measurements that are
conducted with digital systems.
Conclusions
This study showed that the new TDR parameters: Tp-e interval,
Tp-e/QT ratio and QTd were increased in children with ARC;
however, the heterogeneity of TDR seems to occur independently
of acute inflammation and the number of valves involved. The
prolonged Tp-e interval and increased Tp-e/QT ratio might be
useful markers for predicting myocardial involvement in children
with ARC. These parameters may be used as minor criteria
in RF. Therefore prospective follow-up studies are needed to
evaluate TDR parameters in children with RC, both before and
after treatment.
References
1.
Parnaby MG, Carapetis JR. Rheumatic fever in indigenous Australian
children
. J Paediatr Child Health
2010;
46
: 527–533.
2.
Guilherme L, Kalil J. Rheumatic fever and rheumatic heart disease:
Cellular mechanisms leading to autoimmune reactivity and disease.
J
Clin Immunol
2010;
30
: 17–23.
3.
Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden
of group A streptococcal diseases.
Lancet Infect Dis
2005;
5
: 685–694.
4.
Carapetis JR, McDonald M, Wilson NJ. Acute rheumatic fever.
Lancet
2005;
366
(9480): 155–168.
5.
Cunningham MW. Autoimmunity and molecular mimicry in the patho-
genesis of post-streptococcal heart disease.
Front Biosci
2003;
8
: 533–543.
6.
Guilherme L, Oshiro SE, Fae KC,
et al
. T-cell reactivity against strep-
tococcal antigens in the periphery mirrors reactivity of heart infiltrating
T lymphocytes in rheumatic heart disease patients.
Infect Immun
2001;
69
: 5345–5351.
7.
Da Silva NA, Pereira BA. Acute rheumatic fever. Still a challenge.
Rheum Dis Clin North Am
1997;
23
: 545–568.
8.
Remigio de Aguiar MI, Saraiva LC, Santos CL. QT Dispersion predict-
ing acute rheumatic carditis.
Cardiol Young
2010;
20
: 473–476.
9.
Polat TB, Yalcin Y, Akdeniz C, Zeybek C, Erdem A, Celebi A. QT
dispersion in acute rheumatic fever
. Cardiol Young
2006;
16
: 141–146.
10. Alp H, Baysal T, Altın H, Karata
ş
Z, Karaarslan S. QT and P-wave
dispersions in rheumatic heart disease: prospective long-term follow up.
Pediatr Int
2014;
56
: 681–688.
11. Kors JA, Ritsema van Eck HJ, van Herpen G. The meaning of the Tp-Te
interval and its diagnostic value.
J Electrocardiol
2008;
41
: 575–580.
12. Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT,
et al
. T(p-e)/QT ratio as an index of arrhythmogenesis.
J Electrocardiol
2008;
41
: 567–574.
13. Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis
J,
et al.
; American Heart Association Committee on Rheumatic Fever,
Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Disease in the Young. Revision of the Jones criteria for the diagnosis
of acute rheumatic fever in the era of Doppler echocardiography: a
scientific statement from the American Heart Association.
Circulation
2015;
131
(20): 1806–1818.
14. Lai WW, Geva T, Shirali GS, Frommelt PC, Humes RA, Brook MM,
et al
. Guidelines and standards for performance of a pediatric echocar-
diogram: a report from the Task Force of the Pediatric Council of the
American Society of Echocardiography.
J Am Soc Echocardiogr
2006;
19
: 1413–1430.
15. Quiñones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA.
Recommendations for quantification of Doppler echocardiogra-
phy: a report from the Doppler Quantification Task Force of the
Nomenclature and Standards Committee of the American Society of
Echocardiography.
J Am Soc Echocardiogr
2002;
15
: 167–184.
16. Karadeniz C, Ozdemir R, Demir F,
et al
. Increased P-wave and
QT dispersions necessitate long-term follow-up evaluation of Down
syndrome patients with congenitally normal hearts.
Pediatr Cardiol
2014;
35
: 1344–1348.
17. Bazett HC. An analysis of the time relations of electrocardiograms.
Heart
1920;
7
: 353–370
18. Sap F, Karatas Z, Altin H,
et al.
Dispersion durations of P-wave and QT
interval in children with congenital heart disease and pulmonary arterial
hypertension.
Pediatr Cardiol
2013;
34
: 591–596.
19. Kilicaslan F, Tokatli A, Ozdag F,
et al
. Tp-e interval, Tp-e/QT ratio,
and Tp-e/QTc ratio are prolonged in patients with moderate and severe
obstructive sleep apnea.
Pacing Clin Electrophysiol
2012;
35
: 966–972.
20. Dilaveris PE, Gialafos EJ, Sideris SK,
et al
. Simple electrocardiographic
markers for the prediction of paroxysmal idiopathic atrial fibrillation.
Am Heart J
1998;
135
: 733–738.
21. Pye M, Quinn AC, Cobbe SM. QT interval dispersion: a noninvasive
marker of susceptibility to arrhythmia in patients with sustained
ventricular arrhythmias?
Br Heart J
1994;
71
: 511–514.
22. Higham PD, Hilton CJ, Aitcheson DA, Furniss SS, Bourke JP, Campbell
RWF. QT dispersion does reflect regional variation in ventricular recov-
ery.
Circulation
1992;
86
: 1–392.
23. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and
the electrocardiographic manifestations of the long-QT syndrome.
Circulation
1998;
98
: 1928–1936.
24. Yan GX, Martin J. Electrocardiographic T wave: a symbol of trans-
mural dispersion of repolarization in the ventricles.
J Cardiovasc
Electrophysiol
2003;
14
: 639–640.
25. Haarmark C, Hansen PR, Vedel-Larsen E,
et al
. The prognostic value of
the Tpeak–Tend interval in patients undergoing primary percutaneous
coronary intervention for ST-segment elevation myocardial infarction.
J
Electrocardiol
2009;
42
: 555–560.
26. Castro Hevia J, Antzelevitch C, Tornes Barzaga F,
et al
. Tpeak–Tend
and Tpeak–Tend dispersion as risk factors for ventricular tachycardia/
ventricular fibrillation in patients with the Brugada syndrome.
J Am
Coll Cardiol
2006;
47
: 1828–1834.
27. Panikkath R, Reinier K, Uy-Evanado A,
et al
. Prolonged Tpeak-to-
Tend interval on the resting ECG is associated with increased risk of
sudden cardiac death.
Circ Arrhythm Electrophysiol
2011;
4
: 441–447.
28. Lubinski A, Kornacewicz-Jach Z, Wnuk-Wojnar AM,
et al.
The termi-
nal portion of the T wave: a new electrocardiographic marker of risk of
ventricular arrhythmias.
Pacing Clin Electrophysiol
2000;
23
: 1957–1959.
29. Mozos I, Serban C. The relation between QT interval and T-wave vari-
ables in hypertensive patients.
J Pharm Bioallied Sci
2011;
3
: 339–344.
30. Acar G, Yorgun H, Inci MF,
et al
. Evaluation of Tp-e interval and Tp-e/
QT ratio in patients with ankylosing spondylitis.
Mod Rheumatol
2014;
24
: 327–330.
31. Akcay A, Acar G, Sayarlioglu M,
et al
. QT dispersion and transmural
dispersion of repolarization in patients with familial Mediterranean
fever.
Mod Rheumatol
2009;
19
: 550–555.