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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 31, No 3, May/June 2020

AFRICA

161

8.

Sodi-Pallares D, Ponce de León J, Bisteni A, Medrano GA. Potassium,

glucose, and insulin in myocardial infarction.

Lancet

1969;

1

(7609):

1315–1316.

9.

Reikerås O, Gunnes P, Sorlie D, Ekroth R, Mjos OD. Metabolic effects

of high doses of insulin during acute left ventricular failure in dogs.

Eur

Heart

J 1985;

6

: 458–464.

10. Grossman AN,

Opie

LH, Beshansky JR, Ingwall JS, Rackley CE,

Selker

HP. Glucose-insulin-potassium revived: current status in acute

coronary syndromes and the energy-depleted heart.

Circulation

2013;

127

: 1040–1048.

11. Carvalho G, Pelletier P, Albacker T,

et al.

Cardioprotective effects of

glucose and insulin administration while maintaining normoglycemia

(GIN therapy) in patients undergoing coronary artery bypass grafting.

J Clin Endocrinol Metab

2011;

96

(5): 1469–1477.

12. Selker HP, Beshansky JR, Sheehan PR,

et al.

Out-of-hospital admin-

istration of intravenous glucose-insulin-potassium in patients with

suspected acute coronary syndromes: the IMMEDIATE randomized

controlled trial.

J Am Med Assoc

2012;

307

(18): 1925–1933.

13. Deedwania P, Kosiborod M, Barrett E,

et al.

Hyperglycemia and acute

coronary syndrome: a scientific statement from the American Heart

Association Diabetes Committee of the Council on Nutrition, Physical

Activity, and Metabolism.

Circulation

2008;

117

(12): 1610–1619.

14. Ferrannini G, de Bacquer D, de Backer G, Kotseva K, Mellbin L, Wood

D, Ryden L on behalf of the EUROASPIRE V collaborators. Screening

for glucose perturbations and risk factor management in dysglycemic

patients with coronary artery disease – a persistent challenge in need of

substantial improvement: a report from ESC EORP EUROASPIRE V.

Diabetes Care

2020;

43

: 726–733.

Significant financial stress associated with 13-fold higher odds of having a heart attack

Significant financial stress is associated with a 13-fold

higher odds of having a heart attack, according to research

presented at the 18th Annual Congress of the South African

Heart Association.

‘The role of psychosocial factors in causing disease is a

neglected area of study in South Africa, perhaps because

there are so many other pressing health challenges such

as tuberculosis and HIV,’ said lead author Dr Denishan

Govender, associate lecturer, University of theWitwatersrand,

Johannesburg.

‘The INTERHEART study showed that psychosocial

factors are independently associated with acute myocardial

infarction (heart attack) in Africa but as far as we are aware

there are no other published local data,’ said last author

Professor Pravin Manga, professor of cardiology, University

of the Witwatersrand.

This study included 106 patients with acute myocardial

infarction who presented to a large public hospital in

Johannesburg. A control group of 106 patients without cardiac

disease was matched for age, gender and race. All participants

completed a questionnaire about depression, anxiety, stress,

work stress and financial stress in the previous month. The

Likert scale was used to grade the experience of each condition.

Regarding financial stress, patients were graded with no

financial stress if they were coping financially; mild financial

stress if they were coping financially but needed added

support; moderate financial stress if they had an income

but were in financial distress; and significant financial stress

if they had no income and at times struggled to meet basic

needs. Levels of psychosocial conditions were compared

between groups and used to calculate associations with

having a heart attack.

Self-reported stress levels were common, with 96% of

heart attack patients reporting any level of stress, and 40%

reporting severe stress levels. There was a three-fold increased

risk of myocardial infarction if a patient had experienced

any level of depression (from mild to extremely severe) in the

previous month compared to those with no depression.

Both work stress and financial stress were associated

with a higher risk of acute myocardial infarction. The odds

of myocardial infarction was 5.6 times higher in patients

with moderate or severe work stress compared to those with

minimal or no stress. Patients with significant financial stress

had a 13-fold higher odds of having a myocardial infarction.

Dr Govender said: ‘Our study suggests that psychosocial

aspects are important risk factors for acute myocardial

infarction. Often patients are counselled about stress after

a heart attack but there needs to be more emphasis prior to

an event. Few doctors ask about stress, depression or anxiety

during a general physical and this should become routine

practice, like asking about smoking. Just as we provide advice

on how to quit smoking, patients need information on how

to fight stress.’

Professor Manga said: ‘There is growing recognition that

many developing countries are experiencing an increasing

prevalence of chronic diseases of lifestyle such as myocardial

infarction, and South Africa is no exception. Our study

shows that psychosocial aspects are an area of cardiovascular

prevention that deserves more attention.’

Dr David Jankelow, chairman of the SA Heart 2017

congress, commented: ‘We know that the depressed cardiac

patient is at greater risk. We as clinicians need to identify

themmuch earlier, so that they can be referred for appropriate

intervention. Cardiac rehabilitation together with counselling

and reassurance will play an important role as well.’

Professor Fausto Pinto, ESC immediate past president and

course director of the ESC programme in South Africa, said:

‘Psychosocial factors including stress at work, depression and

anxiety contribute to the risk of developing cardiovascular

disease and having a worse prognosis. European prevention

guidelines say that psychosocial risk-factor assessment

should be considered in people with, or at high risk of,

cardiovascular disease to identify possible barriers to lifestyle

change or adherence to medication.’

Source:

European Society of Cardiology Press Office