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21 / 64

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 31, No 3, May/June 2020 AFRICA 129
1996: 380: 435–439.
21. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications
of angiogenesis. Nature 2011: 473: 298–307.
22. Klufas MA, Chan RV. Intravitreal anti-VEGF therapy as a treatment
for retinopathy of prematurity: what we know after 7 years. J Pediatr
Ophthalmol Strabismus 2015: 52: 77–84.
23. Eldweik L, Mantagos IS. Role of VEGF inhibition in the treatment of
retinopathy of prematurity. Semin Ophthalmol 2016: 31: 163–168.
24. Wong RK, Hubschman S, Tsui I. Reactivation of retinopathy of prema-
turity after ranibizumab treatment. Retina 2015: 35: 675–680.
25. Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, et
al. New insights in diagnosis and treatment for retinopathy of prematu-
rity. Int Ophthalmol 2016: 36: 751–760.
26. Belcik JT, Qi Y, Kaufmann BA, et al. Cardiovascular and systemic
microvascular effects of anti-vascular endothelial growth factor therapy
for cancer. J Am Coll Cardiol 2012: 60: 618–625.
27. Hu K, Liu D, Herrmann S, et al. Clinical implication of mitral annular
plane systolic excursion for patients with cardiovascular disease. Eur
Heart J Cardiovasc Imaging 2013: 14: 205–212.
28. O’Leary PW. Pediatric diastology: use and limitations of Doppler
echocardiography in the evaluation of ventricular diastolic function in
children. Prog Pediatr Cardiol 1999: 10: 83–93.
29. Anavekar NS, Oh JK. Doppler echocardiography: a contemporary
review. J Cardiol 2009: 54: 347–358.
30. Bruch C, Marin D, Kuntz S, et al. [Analysis of mitral annulus excursion
with tissue Doppler echocardiography. Noninvasive assessment of left
ventricular, diastolic dysfunction]. Z Kardiol 1999: 88: 353–362.
31. Waggoner AD, Bierig SM. Tissue Doppler imaging: a useful echocar-
diographic method for the cardiac sonographer to assess systolic and
diastolic ventricular function. J Am Soc Echocard 2001: 14: 1143–1152.
32. Cho JY, Kim KH. Evaluation of arterial stiffness by echocardiography:
methodological aspects. Chonnam Med J 2016: 52: 101–106.
Trust the ! Original
S3 ISMO-20 R/7.1.4/136. Isosorbide-5-mononitrate 20 mg/tablet.
For full prescribing information, please refer to package insert.
Pharmaco Distribution (Pty) Ltd. 3 Sandown Valley Crescent, South Tower, 1st Floor, Sandton, 2196; PO Box 786522, Sandton, 2146, South Africa. Tel: + 27 11 784 0077.
Website:
1 Long-term prophylaxis and management of Angina Pectoris
2,3 = 100% bioavailability No first-pass metabolism
4 Twice daily dosage regimen shown to avoid withdrawal and tolerance
References: 1. South African approved ISMO package insert. 2. Ismo 20 Product Monograph (2015). 3. Abshagen, U., 1992. Pharmacokinetics of isosorbide mononitrate.
The American Journal of Cardiology, [online] 70(17), pp.G61-G66. 4. Thadani U, Maranda CR, Amsterdam E, et al. Lack of Pharmacological Tolerance and Rebound
Angina Pectoris during Twice-daily Therapy with Isosorbide-5-Mononitrate. Annals of Internal Medicine. 1994; 120:353-359. IS_0120.