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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 32, No 4, July/August 2021
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Long term prophylaxis and management
of Angina Pectoris
1
No first-pass metabolism.
100% bioavalability
2,3
Twice-daily dosing
regimen shown to avoid withdrawal and tolerance
4
References:
1.
Ismo
®
South African SAHPRA aproved package insert.
2.
Ismo 20 Product Monograph(2015)
.
3.
Abshagen,U. 1992. Pharmacokinetics of isosorbide mononitrate. The American Journal of Cradiology,
[online] 70 (17),pp.G61-G66
4.
Thadani U, Maranda CR, Amsterdam E, et al. Lack of Pharmacological Tolerance and Rebound Angina Pectoris during Twice-daily Therapy with isosorbide-5-mononitrate.
Annals of Internal Medicine. 1994.; 120: 353-359.
ISMO
®
-20 R/7.1.4/136. Each Ismo
®
-20 Tablet contains Isosorbide-5-mononitrate 20mg.
S3
For full prescribing information, please refer to the approved package insert
Pharmaco Distribution (Pty) Ltd.
3 Sandown Valley Crescent, South Tower, 1st Floor
Sandton, 2196. PO Box 786522, Sandton, 2146. South Africa
Tel: +27 11 784 0077. Fax: +27 11 784 6994.
www.pharmaco.co.zaISA_21_01
Trust the Original!
abdominal aortic aneurysm in the Medicare population.
N Engl J Med
2015;
373
(4): 328–338.
12. Bastos RM, Filho AR, Blasbalg R, Caffaro RA, Karakhanian WK,
Rocha AJ. A multidetector tomography protocol for follow-up of endo-
vascular aortic aneurysm repair.
Clinics
2011;
66
(12): 2025–2029.
13. Ay D, Erdolu B, Yumun G,
et al
. The effect of anatomical factors on
mortality rates after endovascular aneurysm repair.
Cardiovasc J Afr
2016;
27
(1): 12–15.
14. Cho JS, Dillavou ED, Rhee RY, Makaroun MS. Late abdominal aortic
aneurysm enlargement after endovascular repair with the Excluder
device.
J Vasc Surg
2004;
39
(6): 1236–1241; discussion 2141–2142.
15. Rand T, Uberoi R, Cil B, Munneke G, Tsetis D. Quality improvement
guidelines for imaging detection and treatment of endoleaks following
endovascular aneurysm repair (EVAR
). Cardiovasc Intervent Radiol
2012;
36
(1): 35–45.
16. Stavropoulos SW, Charagundla SR. Imaging techniques for detection
and management of endoleaks after endovascular aortic aneurysm
repair.
Radiology
2007;
243
(3): 641–655.
17. Rhee SJ, Ohki T, Veith FJ, Kurvers H. Current status of management of
type II endoleaks after endovascular repair of abdominal aortic aneu-
rysms.
Ann Vasc Surg
2003;
17
(3): 335–344.
18. Cao P, De Rango P, Verzini F, Parlani G. Endoleak after endovascular
aortic repair: classification, diagnosis and management following endo-
vascular thoracic and abdominal aortic repair.
J Cardiovasc Surg
2010;
51
(1): 53–69.
19. Broker HS, Foteh KI, Murphy EH,
et al
. Device-specific aneurysm sac
morphology after endovascular aneurysm repair: evaluation of contem-
porary graft materials.
J Vasc Surg
2008;
47
(4): 702–706.
20. Sirignano P, Menna D, Capoccia L,
et al.
Preoperative intrasac throm-
bus load predicts worse outcome after elective endovascular repair
of abdominal aortic aneurysms.
J Vasc Interv Radiol
2015;
26
(10):
1431–1436.
21. Blankensteijn J.D, Prinssen M. Does fresh clot shrink faster than preex-
istent mural thrombus after endovascular AAA repair?
J Endovasc Ther
2002;
9
: 458–463.
22. Çil BE, Canyi
ğ
it M, Çiftçi TT,
et al
. Endovascular treatment of aortic
lesions using the Medtronic
®
Talent system: single center experience with
mid-term follow-up.
Anatol J Cardiol
2008;
8
(2): 134–138.