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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 27, No 5, September/October 2016

298

AFRICA

22. Altura BM, Altura BT, Carella A, Gebrewold A, Murakawa T, Nishio

A. Mg

2

+

–Ca

2

+

interaction in contractility of vascular smooth muscle:

Mg

2

+

versus organic calcium channel blockers on myogenic tone

and agonist-induced responsiveness of blood vessels.

Can J Physiol

Pharmacol

1987;

65

: 729–745.

23. Euser AG, Cipolla MJ. Magnesium sulfate for the treatment of eclamp-

sia: a brief review.

Stroke

2009;

40

(4): 1169–1175.

24. Yener AU, Ozkan T, Cicek MC, Baysal E, Dogan E, Cicek OF,

et al

.

Magnesium; the electrolyte that delays the formation of atrial fibrilla-

tion.

Exp Clin Cardiol

2014;

20

(1): 2624–2633.

25. Vigorito C, Giordano A, Ferraro P, Acanfora D, De Caprio L, Naddeo

C,

et al

. Hemodynamic effects of magnesium sulfate on the normal

human heart.

Am J Cardiol

1991;

67

(16): 1435–1437.

26. Resnick LM, Gupta RK, DiFabio B, Barbagallo M, Mann S, Marion R,

et al

. Intracellular ionic consequences of dietary salt loading in essential

hypertension. Relation to blood pressure and effects of calcium channel

blockade.

J Clin Invest

1994;

94

(3): 1269–1276.

27. Cunningham J, Rodrıguez M, Messa P. Magnesium in chronic kidney

disease Stages 3 and 4 and in dialysis patients.

Clin Kidney J

2012;

5

(Suppl 1): i39–i51.

28. Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship

between serum magnesium values, lipids and anthropometric risk

factors.

Atherosclerosis

2008;

196

: 413–419.

Confidence Through Clinical

and Real World Experience

1-3

Millions of Patients Treated Across Multiple Indications

4

#1 NOAC prescribed by Cardiologists

*

References:

1.

Patel M.R., Mahaffey K.W., Garg J.

et al.

Rivaroxaban versus warfarin in non-valvular atrial fibrillation.

N Engl J Med

. 2011;365(10):883–91.

2.

Tamayo S., Peacock W.F., Patel M.R.,

et al.

Characterizing major bleeding in patients with nonvalvular atrial fibrillation: A pharmacovigilance study of 27 467 patients taking rivaroxaban.

Clin Cardiol

. 2015;38(2):63–8.

3.

Camm A.J., Amarenco P., Haas S.

et al.

XANTUS: A Real-World,

Prospective, Observational Study.

4.

Calculation based on IMS Health MIDAS, Database: Monthly Sales December 2015.

For fullprescribing information,refer to thepackage insertapprovedby theMedicinesRegulatoryAuthority (MCC). S4 XARELTO

®

10 (Film-coated tablets)

.Reg.No.

:42/8.2/1046.Eachfilm-coated tabletcontainsrivaroxaban10mg.

PHARMACOLOGICALCLASSIFICATION:

A.8.2Anticoagulants.

INDICATION:

Prevention of venous thromboembolism (VTE) in patients undergoing major orthopaedic surgery of the lower limbs. S4 XARELTO

®

15 and XARELTO

®

20 (Film-coated tablets). Reg. No.: XARELTO

®

15: 46/8.2/0111; XARELTO

®

20: 46/8.2/0112. Each film

coated tablet contains rivaroxaban 15 mg (XARELTO

®

15) or 20 mg (XARELTO

®

20).

PHARMACOLOGICAL CLASSIFICATION:

A.8.2 Anticoagulants.

INDICATIONS:

(1) Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (SPAF); (2)

Treatment of deep vein thrombosis (DVT) and for the prevention of recurrent deep vein thrombosis (DVT) and pulmonary embolism (PE); (3) Treatment of pulmonary embolism (PE) and for the prevention of recurrent pulmonary embolism (PE) and deep vein thrombosis (DVT).

HCR:

Bayer (Pty) Ltd, Reg. No.: 1968/011192/07, 27 Wrench Road, Isando, 1609. Tel: 011 921 5044 Fax: 011 921 5041.

L.ZA.MKT.GM.01.2016.1265

*Impact RX Data Oct - Dec 2015

NOAC: Non Vitamin K Oral Anticoagulant