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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 28, No 1, January/February 2017

AFRICA

7

myocardial infarction.

Am Heart J

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. Frequency, significance and cost of recurrent ischemia after

thrombolytic therapy for acute myocardial infarction. TAMI Study

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. Am J Cardiol

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7.

Uzunhasan I, Bader K, Okçun B, Hatemi AC, Mutlu H. Correlation of

the Tei index with left ventricular dilatation and mortality in patients

with acute myocardial infarction.

Int Heart J

2006;

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8.

Karatzis EN, Giannakopoulou AT, Papadakis JE, Karazachos AV,

Nearchou NS. Myocardial performance index (Tei index): Evaluating its

application to myocardial infarction.

Hellenic J Cardiol

2009;

50

: 60–65.

PubMed PMID: 19196622.

9.

Poulsen SH, Jensen SE, Nielsen JC, Møller JE, Egstrup K. Serial

changes and prognostic implications of a Doppler derived index of

combined left ventricular systolic and diastolic myocardial performance

in acute myocardial infarction.

Am J Cardiol

2000;

85

: 19–25. PubMed

PMID: 11078230.

10. Sahin DY, Gür M, Elbasan Z, Uysal OK, Özaltun B,

Ş

eker T,

et al

.

Relationship between myocardial performance index and severity of

coronary artery disease assessed with SYNTAX score in stable coronary

artery disease.

Echocardiography

2013;

30

(4): 385–391. PubMed PMID:

23228100.

11. Turfan M, Akyel A, Bolayir HA, Vatankulu MA, Aktürk M, Yetkin I,

et

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. Correlation of the myocardial performance index with plasma B-type

natriureticpeptide levels in type 2 diabetes mellitus and impaired glucose

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Kardiol Pol

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12. Mandelzweig L, Battler A, Boyko V, Bueno H, Danchin N, Filippatos

G,

et al

. The second Euro Heart Survey on acute coronary syndromes:

characteristics, treatment, and outcome of patients with ACS in Europe

and the Mediterranean Basin in 2004.

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2006;

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PubMed PMID: 16908490.

Confidence Through Clinical

and Real World Experience

1-3

Millions of Patients Treated Across Multiple Indications

4

#1 NOAC prescribed by Cardiologists

*

References:

1.

Patel M.R., Mahaffey K.W., Garg J.

et al.

Rivaroxaban versus warfarin in non-valvular atrial fibrillation.

N Engl J Med

. 2011;365(10):883–91.

2.

Tamayo S., Peacock W.F., Patel M.R.,

et al.

Characterizing major bleeding in patients with nonvalvular atrial fibrillation: A pharmacovigilance study of 27 467 patients taking rivaroxaban.

Clin Cardiol

. 2015;38(2):63–8.

3.

Camm A.J., Amarenco P., Haas S.

et al.

XANTUS: A Real-World,

Prospective, Observational Study.

4.

Calculation based on IMS Health MIDAS, Database: Monthly Sales December 2015.

For fullprescribing information,refer to thepackage insertapprovedby theMedicinesRegulatoryAuthority (MCC). S4 XARELTO

®

10 (Film-coated tablets)

.Reg.No.

:42/8.2/1046.Eachfilm-coated tabletcontainsrivaroxaban10mg.

PHARMACOLOGICALCLASSIFICATION:

A.8.2Anticoagulants.

INDICATION:

Prevention of venous thromboembolism (VTE) in patients undergoing major orthopaedic surgery of the lower limbs. S4 XARELTO

®

15 and XARELTO

®

20 (Film-coated tablets). Reg. No.: XARELTO

®

15: 46/8.2/0111; XARELTO

®

20: 46/8.2/0112. Each film

coated tablet contains rivaroxaban 15 mg (XARELTO

®

15) or 20 mg (XARELTO

®

20).

PHARMACOLOGICAL CLASSIFICATION:

A.8.2 Anticoagulants.

INDICATIONS:

(1) Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (SPAF); (2)

Treatment of deep vein thrombosis (DVT) and for the prevention of recurrent deep vein thrombosis (DVT) and pulmonary embolism (PE); (3) Treatment of pulmonary embolism (PE) and for the prevention of recurrent pulmonary embolism (PE) and deep vein thrombosis (DVT).

HCR:

Bayer (Pty) Ltd, Reg. No.: 1968/011192/07, 27 Wrench Road, Isando, 1609. Tel: 011 921 5044 Fax: 011 921 5041.

L.ZA.MKT.GM.01.2016.1265

*Impact RX Data Oct - Dec 2015

NOAC: Non Vitamin K Oral Anticoagulant