CARDIOVASCULAR JOURNAL OF AFRICA • Vol 24, No 7, August 2013
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AFRICA
the literature. We surmise this was because of their more risky
profiles despite the fact that their EuroSCOREs were similar
to those of the control group. Rates of mortality and morbidity
were found to be similar in both groups, possibly due to the small
number of patients in the study.
Conclusion
Our study shows that pre-operative use of levosimendan in
cardiac valve surgery patients with low ejection fractions
and/or pulmonary arterial hypertension resulted in improved
haemodynamic parameters, which may have provided better and
faster recovery after CPB. In larger studies with more patients,
the positive effects of levosimendan on clinical outcomes may be
seen more clearly.
References
1.
Cevese PG, Gallucci V, Valfre C, et al. Pulmonary hypertension in
mitral valve surgery.
J Cardiovasc Surg (Torino)
1980;
2
1: 7–10.
2.
Vincens JJ, Temizer D, Post JR,
et al
. Long-term outcome of cardiac
surgery in patients with mitral stenosis and severe pulmonary hyperten-
sion.
Circulation
1995;
92
: II137–142.
3.
Figgit DP, Gillies PS, Goa KL. Levosimendan.
Drugs
2001;
61
:
613–627.
4.
De Hert SG, Lorsomradee S, Cromheecke S,
et al
. The effects of levo-
simendan in cardiac surgery patients with poor left ventricular function.
Anesth Analg
2007;
104
: 766–773.
5.
Toller WG, Stranz C. Levosimendan, a new inotropic and vasodilator
agent.
Anesthesiology
2006;
104
: 556–569.
6.
Raja SG, Rayen BS. Levosimendan in cardiac surgery: current best
available evidence.
Ann Thorac Surg
2006;
81
: 1536–1546.
7.
Mebazaa A, Barraud D, Welschbillig S. Randomized clinical trials with
levosimendan.
Am J Cardiol
2005;
96
: 74G–79G.
8.
Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents
for acute heart failure syndromes.
Am J Cardiol
2005;
96
: 68G–73G.
9.
McBride BF, White CM. Levosimendan: implications for clinicians.
J
Clin Pharmacol
2003;
43
: 1071–1081.
10. Tritapepe L, De Santis V, Vitale D,
et al.
Preconditioning effects of
levosimendan in coronary artery bypass grafting--a pilot study.
Br J
Anaesth
2006;
96
: 694–700.
11. Leppikangas H, Järvelä K, Sisto T,
et al
. Preoperative levosimendan
infusion in combined aortic valve and coronary bypass surgery.
Br J
Anaesth
2011;
106
: 298–304.
12. Brezina A, Riha H, Pirk J. Prophylactic application of levosimendan in
cardiac surgical patients with severe left ventricle dysfunction.
Exp Clin
Cardiol
2009;
14
: e31–34.
13. Tritapepe L, De Santis V, Vitale D,
et al
. Levosimendan pre-treatment
improves outcomes in patients undergoing coronary artery bypass graft
surgery.
Br J Anaesth
2009;
102
: 198–204.
14. Follath F, Franco F, Cardoso JS. European experience on the practical
use of levosimendan in patients with acute heart failure syndromes.
Am
J Cardiol
2005;
96
: 80G–85G.
15. Tachibana H, Cheng HJ, Ukai T,
et al
. Levosimendan improves LV
systolic and diastolic performance at rest and during exercise after heart
failure.
Am J Physiol Heart Circ Physiol
2005;
288
: H914–922.
16. Lilleberg J, Nieminen MS, Akkila J,
et al.
Effects of a new calcium
sensitizer, levosimendan, on haemodynamics, coronary blood flow and
myocardial substrate utilization early after coronary artery bypass graft-
ing.
Eur Heart
J 1998;
19
: 660–668.