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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 31, No 6, November/December 2020
302
AFRICA
Elevated UA level was significantly associated with the
metabolic syndrome and dyslipidaemia, including high LDL-C
levels, hypercholesterolaemia and hypertriglyceridaemia.
27
Hypercholesterolaemia was significantly associated with higher
cardiovascular disease risk,
28
and hyperhomocysteinaemia was
significantly associated with stroke risk.
29
Therefore, we selected
TC, TG, Hcy and LDL-C to combine with UA.
The combination of UA
+
Hcy
+
TG-TC-LDL-C- could
significantly increase the risk of stroke for females and all
participants. There were also significant associations
between the combinations UA
+
Hcy
+
TG
+
TC
+
LDL-C- and
UA
+
Hcy
+
TG
+
TC
+
LDL-C
+
and the risk of stroke. However, the
sample size was relatively small with some of these combinations.
More studies with larger sample sizes are needed to shed light on
the association between the combinations of UA level and other
serological indicators and stroke risk.
As a community-based, cross-sectional study, we must
consider the limitations in deriving conclusions. First, based
on the characteristics of a cross-sectional study, our results
can be used as a preliminary cause hypothesis only and further
research is needed to verify the hypothesis. Second, due to the
small sample size of HS, we did not explore the association
between UA level and HS across quartiles of UA. Finally, in
estimating the associations between different combinations of
UA, Hcy, TG, TC and LDL-C and stroke, the small sample sizes
of different combinations may have limited the statistical power.
Conclusion
We observed significant associations between UA level and stroke
as well as IS in females but not in males. Female hypertensive
patients may benefit from managing UA at the normal levels for
stroke prevention.
This work was supported by the Sanming Project of Medicine in Shenzhen
[SZSM201803080], the Nanshan Science and Technology Innovation Bureau
[No. 2017057], the Philosophy and Social Sciences key research-based project
in Shaanxi Province (JKWH2019-Z03), the Philosophy and Social Sciences
research planning project in Heilongjiang Province (18GLB030), and the
Sichuan Medical and Health Law Research Center Project (YF18-Y03).
Jing Shi and Guanyun Yan contributed equally to this article. Fulan Hu
and Ran Wang contributed equally to this article.
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