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CARDIOVASCULAR JOURNAL OF AFRICA • Volume 32, No 4, July/August 2021
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207
inhibitors.
23
This fact is illustrated by findings that elevated EAT
aromatase levels may delay or prevent the occurrence of various
cardiovascular diseases
.
In this study we found a significant negative correlation
between severity of coronary artery lesions and level of aromatase
protein in the CHD group. However, aromatase activity was not
evaluated in this study and the relationship between aromatase
protein level, aromatase activity and coronary artery disease
needs further study.
Conclusion
Our data show that reduced aromatase expression in EAT
correlated with coronary atherosclerotic lesions. Decreased
EAT aromatase protein levels may aggravate the severity of
atherosclerosis. Future studies should evaluate the mechanisms
regulating aromatase transcription and translation in EAT.
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