Copyright: Clinics Cardive Publishing (Pty) Ltd. publisher
of Cardiovascular Journal of Africa.
Abstract
Aim:
Infective endocarditis remains a serious condition with a high mortality rate. However, surgical treatment of infective endocarditis still raises some questions despite the researches. This study aimed to analyse the early- and mid-term outcomes of patients with infective endocarditis who required surgical treatment and to identify perioperative risk factors for mortality and morbidity.
Methods: Between April 2019 and January 2024, 70 patients who were diagnosed with infective endocarditis according to the Modified Duke criteria and underwent cardiac surgery in our clinic, retrospectively.
Results: The results showed that in the preoperative period, older age, previous surgery/intervention, and chronic renal failure were associated with higher mortality in the postoperative period. Long cross-clamp and cardiopulmonary bypass times increased the mortality as the complexity of the intraoperative case increased. Patients requiring postoperative mechanical and inotropic support had a worse prognosis (p<0.05).
Conclusion: The present study identified potential genetic markers increasing susceptibility/risk of MI in the study population. Our study provides a platform for future large scale genetic studies and identifying individuals who at risk of developing MI. The present study emphasise the development of treatments strategies based on genetic make- up of individual.
Glossary of Abbreviations: IE: Infective Endocarditis, CT: Computed Tomography, CABG: Coronary Artery Bypass Grafting, AVR: Aortic Valve Replacement, MVR: Mitral Valve Replacement, TVR: Tricuspid Valve Replacement, PVR: Pulmonary Valve Replacement, MBVP: Mitral Balloon Valvuloplasty, ECMO: Extracorporeal Membrane Oxygenation, IABP: Intraaortic Balloon Pump, MAIF: Mitral-aortic intervalvular fibrosa, CPB: Cardiopulmonary Bypass, CPR: Cardiopulmonary Resuscitation.
Methods: Between April 2019 and January 2024, 70 patients who were diagnosed with infective endocarditis according to the Modified Duke criteria and underwent cardiac surgery in our clinic, retrospectively.
Results: The results showed that in the preoperative period, older age, previous surgery/intervention, and chronic renal failure were associated with higher mortality in the postoperative period. Long cross-clamp and cardiopulmonary bypass times increased the mortality as the complexity of the intraoperative case increased. Patients requiring postoperative mechanical and inotropic support had a worse prognosis (p<0.05).
Conclusion: The present study identified potential genetic markers increasing susceptibility/risk of MI in the study population. Our study provides a platform for future large scale genetic studies and identifying individuals who at risk of developing MI. The present study emphasise the development of treatments strategies based on genetic make- up of individual.
Glossary of Abbreviations: IE: Infective Endocarditis, CT: Computed Tomography, CABG: Coronary Artery Bypass Grafting, AVR: Aortic Valve Replacement, MVR: Mitral Valve Replacement, TVR: Tricuspid Valve Replacement, PVR: Pulmonary Valve Replacement, MBVP: Mitral Balloon Valvuloplasty, ECMO: Extracorporeal Membrane Oxygenation, IABP: Intraaortic Balloon Pump, MAIF: Mitral-aortic intervalvular fibrosa, CPB: Cardiopulmonary Bypass, CPR: Cardiopulmonary Resuscitation.
Keywords:
Infective Endocarditis, Cardiac surgery
Submitted: November 29, 2024;
Accepted: January 30, 2025;
Published: June 30, 2025
Cardiovasc J Afr 2025; 36: 102-109
Volume 36, Issue 2
Cardiovasc J Afr 2025; 36: 102-109
Volume 36, Issue 2
DOI Citation Reference: dx.doi.org/10.5830/CVJA-2025-007