Cardiovascular Journal of Africa

Volume 36, Issue 3

Secondary prevention and management of dyslipidaemia in patients with coronary artery disease on statin therapy in a tertiary academic centre in Johannesburg

Optimal low-density lipoprotein cholesterol (LDL-C) control in patients with established atherosclerotic cardiovascular disease (ASCVD) is defined as LDL-C levels less than 1.4 mmol/L and a reduction of >50% in baseline LDL-C levels. This study aims to assess LDL-C control in patients with ASCVD on statin treatment in a tertiary academic hospital.

Right ventricular function, pulmonary hypertension and incident mortality in heart failure: Insights from a West-African cohort

Few studies have assessed the prevalence and independent prognostic relevance of right ventricular dysfunction (RVD) and pulmonary hypertension (PH) in Africans with heart failure (HF) despite the different trajectories of HF in Africans compared to other ethnicities. We investigated the frequency and independent associations of RVD and PH with incident death in Nigerian-Africans with...

Krüppel-like factor 5 transcription factor is a positive regulator of NRG-1 in human coronary artery smooth muscle cells

Structural remodelling of the heart and blood vessels is an important basis for the development of cardiovascular disease. Krüppel-like factor 5 (KLF5), an important regulator of cardiovascular remodelling, promotes vascular smooth muscle cell (VSMC) proliferation and inflammatory responses. Neuregulin 1 (NRGI) is a positive regulator of angiogenesis, and its receptors are human epidermal growth...

Repolarisation disturbances in ischaemic stroke: unveiling the prognostic role of the frontal QRS-T angle

Ischaemic stroke is frequently associated with electrocardiographic (ECG) abnormalities, including repolarisation disturbances. These disturbances, often seen as prolonged QT intervals or altered T-wave morphology, reflect impaired ventricular repolarisation and have been linked to an increased risk of cardiovascular events. One specific marker, the frontal QRS-T angle (FQRS-T angle), which...