CARDIOVASCULAR JOURNAL OF AFRICA • Volume 25, No 3, May/June 2014
110
AFRICA
Mean platelet volume is associated with myocardial
perfusion defect in diabetic patients
Savas Sarikaya, Safak Sahin, Lutfi Akyol, Elif Borekci, Yunus Keser Yilmaz, Fatih Altunkas,
Kayihan Karaman, Seyhan Karacavus, Ali Riza Erbay
Abstract
Aim:
Our aim was to evaluate whether there was a relation-
ship between mean platelet volume and myocardial perfusion
defect in diabetic patients using myocardial perfusion imaging.
Method:
Forty-four diabetic patients with myocardial perfu-
sion defect (group 1) and 44 diabetic patients without myocar-
dial perfusion defect (group 2), matched for age and gender,
were retrospectively examined. Levels of mean platelet
volume (MPV) in the two groups were assessed.
Results:
MPVwas higher in group 1 than group 2 patients (8.76
±
0.76 and 8.25
±
0.78 fl), respectively,
p
=
0.003). Levels of
glucose, triglycerides (TG), total cholesterol (TC), low-density
lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, haemoglobin (Hb) and glycosylated haemoglobin
(HbA
1c
), and body mass index (BMI) in the two groups were
not statistically significantly different. Multivariate logistic
regression analyses showed that MPV was the only variable
independently associated with myocardial perfusion defects
(OR: 2.401, 95% CI: 1.298–4.440,
p
=
0.013).
Conclusion:
This study showed that higher MPV was associat-
ed with myocardial perfusion defects. Higher MPV in diabetic
patients was independently related to myocardial perfusion
defects and may be an indicator of myocardial ischaemia.
Keywords:
myocardial perfusion defect, mean platelet volume,
diabetes mellitus
Submitted 18/7/13, accepted 14/3/14
Cardiovasc J Afr
2014;
25
: 110–113
DOI: 10.5830/CVJA-2014-013
Diabetes mellitus (DM) is considered a coronary artery
risk equivalent.
1
DM is associated with an increased risk
of cardiovascular morbidity and mortality.
2,3
DM may cause
myocardial perfusion defects involving the main coronary artery
and myocardial microvascular circulation. Myocardial perfusion
imaging (MPI) is a useful non-invasive tool to determine whether
there is a myocardial perfusion defect.
4
Platelet volume is a marker of platelet activation and function
and is measured as mean platelet volume (MPV).
5
MPV has
become a prognostic factor in coronary heart disease and may
eventually be accepted as a parameter of platelet activity.
6
MPV
is emerging as a new risk factor for vascular complications of
DM of which atherothrombosis plays a crucial role.
7
However, to the best of our knowledge, there have been no
reports in the literature to evaluate the relationship between
MPV and myocardial perfusion defect using MPI in patients with
diabetes. Our aimwas to evaluate whether there was a relationship
between myocardial perfusion defect using myocardial perfusion
scintigraphy and MPV in selected diabetic patients.
Methods
Eighty-eight patients with type 2 diabetes who had MPI between
January and May 2013 in Bozok and Gaziosmanpa
ş
a universities
were retrospectively examined. Eighty-eight patients were
enrolled in the study and divided into two groups, matched for
age and gender: the myocardial perfusion defect group (group
1) and a group with no myocardial perfusion defect (group 2).
Group 1 consisted of 44 subjects (14 men and 30 women, mean
age: 61.75
±
7.86 years). Group 2 consisted of 44 subjects (12
men and 32 women, mean age: 60.48
±
9.28 years).
Patients with a history of myocardial infarction, unstable
angina pectoris, cardiac surgery, angiographically proven
coronary artery disease, endocrine disorder without diabetes,
systemic inflammatory disease, rhythm disorder, any medication
that could affect the MPV, suspicious scintigraphy results due
to breast attenuation, and aperture and fixed (scar) perfusion
defects were excluded.
The blood samples were withdrawn following a 12-hour fast.
Glucose, creatinine and lipid profiles were determined using
standard methods. For both groups, we measured the MPV from
blood samples that were obtained following venipuncture. The
Department of Cardiology, School of Medicine, Bozok
University, Yozgat, Turkey
Savas Sarikaya, MD
Ali Riza Erbay, MD
Department of Internal Medicine, School of Medicine,
Gaziosmanpaşa University, Tokat, Turkey
Safak Sahin, MD,
Department of Internal Medicine, School of Medicine,
Bozok University, Yozgat, Turkey
Lutfi Akyol, MD
Elif Borekci, MD
Department of Cardiovascular Surgery, School of
Medicine, Bozok University, Yozgat, Turkey
Yunus Keser Yilmaz, MD
Department of Cardiology, School of Medicine,
Gaziosmanpaşa University, Tokat, Turkey
Fatih Altunkas, MD
Kayihan Karaman, MD
Department of Nuclear Medicine, School of Medicine,
Bozok University, Yozgat, Turkey
Seyhan Karacavus, MD
