Background Image
Table of Contents Table of Contents
Previous Page  60 / 68 Next Page
Information
Show Menu
Previous Page 60 / 68 Next Page
Page Background

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 26, No 3, May/June 2015

e10

AFRICA

used much earlier as a rule-out test for TB pericarditis and an

alternative cause could have been sought earlier.

Inmost cases that are treated as TB pericarditis in sub-Saharan

Africa, the clinical criteria are used to make a decision to treat.

In the majority of patients, this is the correct decision, but it

is that occasional patient such as the one described, where the

special tests to make a definitive diagnosis would have clinched

the alternative diagnosis earlier.

This patient illustrates the need to be aware of the rarer causes

of fibrinous pericardial effusion and the need to perform more

tests, such as CT or MRI scans and pericardial biopsy to make

a definitive diagnosis, even in our setting of high TB prevalence.

Unfortunately however, most cases of angiosarcoma present

with metastatic deposits and the options for therapy may not

be available, as it was for this patient. The prognosis tends to be

poor.

References

1.

Ntsekhe M, Mayosi BM. Tuberculous pericarditis with and without

HIV.

Heart Fail Rev

2013;

18

(3): 367–373.

2.

Reuter H, Burgess LJ, Doubel AF. Epidemiology of pericardial effu-

sions at a large academic hospital in South Africa.

Epidemiol Infect

2005;

133

: 393–399.

3.

Maher D, Harries AD. Tuberculous pericardial effusion: a prospective

clinical study in a low resource setting – Blantyre, Malawi.

Int J Tuberc

Lung Dis

1997;

1

: 358–364.

4.

Cegielsk JP, Lwakatare J, Dukes CS,

et al

. Tuberculous pericarditis in

Tanzanian patients with and without HIV infection.

Tuberc Lung Dis

1994;

75

: 429–434.

5.

Reuter H, Burgess L, van Vuuren W, Doubel A. Diagnosing tuberculous

pericarditis.

Q J Med

1999;

12

: 827–839.

6.

Timoteo AT, Brancho LM, Bravio I,

et al

. Primary angiosarcoma of the

pericardium: case report and review of the literature.

Kardiol Pol

2010;

68

(7): 802–805.

7.

Ong P, Greulich S, Schumm J.

et al.

Images in Cardiovascular Medicine:

Favorable course of pericardial angiosarcoma under paclitaxel followed

by pazopanib treatment documented by cardiovascular magnetic reso-

nance imaging.

Circulation

2012;

126

: e279–e281.

8.

Mayer F, Aebert H, Rudert M,

et al

. Primary malignant sarcomas of

the heart and great vessels in adult patients – a single-center experience.

Oncologist

2007;

12

: 1134–1142.

9.

Brinckman SL, van der Wouw P. Images in Cardiovascular Medicine:

Angiosarcoma of the pericardium: a fatal disease

. Circulation

2005;

111

(23): e388–389.

10. Kiyohiro O, Akio O, Motoi K,

et al

. Primary cardiac angiosarcoma

associated with cardiac tamponade. Case report.

Japan Circ J

1999;

63

(10): 822–824.

11. Riles E, Gupta S, Wang D, Tobin K. Primary cardiac angiosarcoma: a

diagnostic challenge in a young man with recurrent pericardial effusions.

Exp Clin Cardiol

2012;

17

(1): 39–42.

12. Syed FF, Mayosi BM. A modern approach to tuberculous pericarditis.

Prog Cardiovasc Dis

2007;

50

(3): 218–236.

13. Pandie S, Peter JG, Kerbelker ZS,

et al

. Diagnostic accuracy of quan-

titative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared

to adenosine deaminase and unstimulated interferon g in a high burden

setting: a prospective study.

BMC Med

2014;

12

: 101. doi: 10.1186/1741-

7015-12-101.