49 / 68
CARDIOVASCULAR JOURNAL OF AFRICA • Volume 26, No 6, November/December 2015
AFRICA
247
150
100
50
0
LV max pressure (mmHg)
Control
ISO ISO + Mg
Mg
Treatment
**
10
5
0
–5
LV end-diastolic
pressure (mmHg)
Control
ISO ISO + Mg
Mg
Treatment
9000
6000
3000
0
dP/dt max (mmHg/s)
Control
ISO ISO + Mg
Mg
Treatment
0
–3000
–6000
–9000
dP/dt min (mmHg/s)
Control
ISO ISO + Mg
Mg
Treatment
**
***
0.09
0.06
0.03
0.00
Systolic duration (s)
Control
ISO ISO + Mg
Mg
Treatment
*
0.09
0.06
0.03
0.00
Diastolic duration (s)
Control
ISO ISO + Mg
Mg
Treatment
Fig. 3.
Effects of ISO and Mg
2+
treatments on haemodynamic parameters in four different groups of rats. A: The maximum left
ventricular (LV) blood pressure, B: LV end-diastolic pressure, C: maximal rate of LV pressure change (dP/dt max), D: minimal
rate of LV pressure change (dP/dt min), E: systolic duration, and F: diastolic duration. Data are presented as mean
±
SEM
(
n
=
8–10 rats per group); *
p
<
0.05; **
p
<
0.01 and ***
p
<
0.001 (treatment vs control).
A
C
E
B
D
F
80
60
40
20
0
Conjugated dienes (
μ
mol/l)
Control
ISO ISO + Mg
Mg
Treatment
6
4
2
0
TBARS (
μ
mol/l)
Control
ISO ISO + Mg
Mg
Treatment
Fig. 4.
Effects of ISO and Mg
2+
on the plasma concentrations of markers of lipid peroxidation in four different groups of rats. Plasma
concentrations of conjugated dienes (A), and thiobarbituric acid-reactive substances (B), measured 24 hours after adminis-
tration of the drugs. Data are presented as mean
±
SEM (
n
=
8–10 rats per group).
A
B