Cardiovascular Journal of Africa: Vol 28 No 1 (January/February 2016)

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 28, No 1, January/February 2017

AFRICA

Adropin is synthesised in the intercalated duct, mucous acinus

and interlobular cells of human salivary glands, and this could

contribute to the high concentrations in saliva. Saliva adropin

levels could also be more useful than serum levels for diagnosing

some metabolic conditions.

Saliva offers advantages over blood, including that collection

is non-invasive and therefore stress free for patients, especially

children,

making it a more suitable choice than serum for

measuring adropin in diagnosing EPACS. However there are

some limitations and difficulties in using ELISA on saliva, since

inhibitors and/or binding proteins could be present and could

negatively affect the quantitative determination of peptides/

proteins.

Overall, four and six hours after EPACS, ROC curve analysis

demonstrated that the saliva adropin concentration reflected

EPACS with 91.7% (at four hours) and 91.7% (at six hours)

sensitivity and 57% (at four hours) and 57% (at six hours)

specificity. Therefore, four and six hours after EPACS, the saliva

adropin concentration showed the same sensitvity and specifity

for diagnosing EPACS as the serum level. All these data promise

new possibilities for the diagnosis of EPACS, besides measuring

other cardiac enzymes and proteins (troponins).

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