Cardiovascular Journal of Africa: Vol 30 No 2 (March/April 2019)

CARDIOVASCULAR JOURNAL OF AFRICA • Volume 30, No 2, March/April 2019

AFRICA

Conclusion

This study is the first to demonstrate the direct inhibitory

effect of All on the I

Na,Late

current in SHR atrial myocytes in a

concentration-dependent fashion. The underlying mechanisms

may be partially explained by their roles in reducing the sodium

channel window current. This provides, at least in part, a

potential for the application of All in anti-arrhythmia patients.

We thank the members of our laboratories for their insight and technical

support, and also the National Natural Science Foundation of China (grant

no. 81870249, 81671731, 81470542).

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