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…continued from page 80
His glucose hypothesis has stood the test of time, and his
discovery of the role of excess cyclic AMP in fatal myocardial
infarction made UCT famous. His scholarship on myocardial
reperfusion proved that insulin can directly protect themyocardium
from ischaemia–reperfusion injury and established the concept of
preconditioning as a powerful form of cardiac protection.
At the time of his retirement, Lionel had published just
under 600 articles in peer-reviewed scientific journals, 31 books
on heart disease (including
Drugs for the Heart
, now in its 9th
edition, and
Heart Physiology
, now in its 4th edition) and 141
book chapters. The National Research Foundation supported
him for 10 years and awarded him an A1 research rating in 2008.
In 2003, Lionel entered a research partnership with Professor
Derek Yellon of the Hatter Institute at the University College
London and established the Hatter Institute at UCT. Together,
they had a prolific research collaboration and established the
cardiology, diabetes and nephrology ‘At The Limits’ conferences,
with
The Lancet
as a partner.
Lionel is remembered by many as the doyen of cardiovascular
medicine and research in Africa and a global leader in the field of
cardioprotection. During his illustrious career, he received many
awards, including the National Order of Mapungubwe in Silver
in 2005, the highest national award in South Africa. He received
honorary doctorates from the Universities of Stellenbosch and
Copenhagen, and election to fellowship of many prestigious
medical societies in this country and globally.
He is survived by wife, Carol, and daughters, Jessica and
Amelia, and grandchildren, Liam and Eva.