Copyright: Clinics Cardive Publishing (Pty) Ltd. publisher
of Cardiovascular Journal of Africa.
Abstract
Background:
Prolonged Tp–Te interval is strongly associated with fatal ventricular arrhythmias and mortality. This association has been demonstrated in various diseases. However, the current literature does not give any information on Tp–Te interval in cardiac amyloid light-chain (AL) amyloidosis.
Methods: We retrospectively screened 116 cardiac AL amyloidosis patients and 35 patients were included in the study. Demographic, laboratory, 12-lead electrocardiographic (QTc, Tp–Te V1–V6) and transthoracic echocardiographic data of the patients were analysed and compared with 35 healthy controls.
Results: QTc and Tp–Te V2–V5 were significantly prolonged in the cardiac AL amyloidosis group (p < 0.05). Also, there was a positive and statistically significant correlation between the parameters of QTc and Tp–Te V3–V6, and also between the parameters of interventricular septum thickness at enddiastole and Tp–Te V2–V5.
Conclusion: We present the first strong evidence of prolonged Tp–Te intervals in patients with cardiac AL amyloidosis. There may also be a relationship between prolonged Tp–Te interval and the development of arrhythmia in this patient group, as in some other groups. There is a need for prospective studies examining the relationship of prolonged Tp–Te interval with arrhythmias and its prognostic significance in cardiac AL amyloidosis.
Methods: We retrospectively screened 116 cardiac AL amyloidosis patients and 35 patients were included in the study. Demographic, laboratory, 12-lead electrocardiographic (QTc, Tp–Te V1–V6) and transthoracic echocardiographic data of the patients were analysed and compared with 35 healthy controls.
Results: QTc and Tp–Te V2–V5 were significantly prolonged in the cardiac AL amyloidosis group (p < 0.05). Also, there was a positive and statistically significant correlation between the parameters of QTc and Tp–Te V3–V6, and also between the parameters of interventricular septum thickness at enddiastole and Tp–Te V2–V5.
Conclusion: We present the first strong evidence of prolonged Tp–Te intervals in patients with cardiac AL amyloidosis. There may also be a relationship between prolonged Tp–Te interval and the development of arrhythmia in this patient group, as in some other groups. There is a need for prospective studies examining the relationship of prolonged Tp–Te interval with arrhythmias and its prognostic significance in cardiac AL amyloidosis.
Keywords:
Tp–Te interval, immunoglobulin light-chain amyloidosis, cardiac amyloidosis, arrhythmia
Submitted: October 14, 2023;
Accepted: November 7, 2023;
Published Online First: January 15, 2024;
Published: December 15, 2024
Cardiovasc J Afr 2024; 35: 351-355
Volume 35, Issue 4
Cardiovasc J Afr 2024; 35: 351-355
Volume 35, Issue 4
DOI Citation Reference: dx.doi.org/10.5830/CVJA-2023-059