Copyright: Clinics Cardive Publishing (Pty) Ltd. publisher
of Cardiovascular Journal of Africa.
Abstract
Introduction:
This study aimed to determine the association between angiotensin converting enzyme (ACE) gene I/D polymorphism and peripartum cardiomyopathy (PPCM) in Kano, Nigeria.
Methods: 50 PPCM patients were consecutively recruited and compared with 50 apparently healthy puerperal women as controls, in Aminu Kano Teaching Hospital, Kano, Nigeria. ACE genotyping was done by polymerase chain reaction method, after obtaining written informed consent.
Results: There was no significant difference in the prevalence of ACE ID and DD genotypes in the PPCM patients versus controls (44.0% vs 36.0%, p = 0.414; and 36.0% versus 40.0%, p = 0.680, respectively). Importantly, the association between ACE gene polymorphism and PPCM was not statistically significant (odds ratio: 1.46, 95% confidence interval: 0.52-4.17; p = 0.477).
Conclusion: The prevalence of ACE gene I/D polymorphism was not significantly different between PPCM patients and controls. ACE gene I/D polymorphism was not associated with PPCM in Kano, Nigeria.
Methods: 50 PPCM patients were consecutively recruited and compared with 50 apparently healthy puerperal women as controls, in Aminu Kano Teaching Hospital, Kano, Nigeria. ACE genotyping was done by polymerase chain reaction method, after obtaining written informed consent.
Results: There was no significant difference in the prevalence of ACE ID and DD genotypes in the PPCM patients versus controls (44.0% vs 36.0%, p = 0.414; and 36.0% versus 40.0%, p = 0.680, respectively). Importantly, the association between ACE gene polymorphism and PPCM was not statistically significant (odds ratio: 1.46, 95% confidence interval: 0.52-4.17; p = 0.477).
Conclusion: The prevalence of ACE gene I/D polymorphism was not significantly different between PPCM patients and controls. ACE gene I/D polymorphism was not associated with PPCM in Kano, Nigeria.
Keywords:
peripartum cardiomyopathy, ACE gene polymorphism, Nigeria
Submitted: May 29, 2024;
Accepted: December 9, 2024;
Published: June 30, 2025
Cardiovasc J Afr 2025; 36: 122-128
Volume 36, Issue 2
Cardiovasc J Afr 2025; 36: 122-128
Volume 36, Issue 2
DOI Citation Reference: dx.doi.org/10.5830/CVJA-2025-010