Cardiovascular Journal of Africa

Validity testing of the novel European Society of Cardiology EURObservational Research Programme PPCM Registry score to predict left ventricular recovery in a cohort of Ugandan women with PPCM

Juliet Nabbaale, Karen Sliwa, Alice Jackson, Elena Libhaber, Emmy Okello, Annette Nakimuli, Graham Chakafana
Abstract
Background: Recently under the European Society of Cardiology (ESC) EURObservational Research Programme (EORP) PPCM registry the first predictive score was derived. This study sought to test the validity of this predictive score in a cohort of women with PPCM in Uganda.
Methods: 80 PPCM cases enrolled had a 12-lead electrocardiography, echocardiography at baseline and at 6-months follow-up. Core clinical data included LVEF, LVEDD, duration of symptoms, QRS duration and pre-eclampsia were captured.
Results: Recovered participants’ scores included one case who scored -1 and one of 2, six cases had a score of 3, fifteen cases had a score of 4, six cases had a score of 5, two cases had a score of 6 and only five cases had the highest score of 7. The discrimination analysis achieved a c-statistic of 0.67.
Conclusion: The ESC EORP PPCM LV predictive recovery score under performed in predicting LV recovery in our Ugandan PPCM cohort.
Keywords: Peripartum cardiomyopathy, LV recovery, Predictive score
Submitted: August 3, 2025; Accepted: September 12, 2025; Published: June 5, 2026
Cardiovasc J Afr 2025; 37: 215-220
Volume 37, Issue 2
DOI Citation Reference: dx.doi.org/10.5830/CVJA-2025-099
Uganda Heart Institute, Upper Mulago Hill, Mulago Hospital
Juliet Nabbaale
Emmy Okello

Cape Heart Institute, Department of Cardiology and Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Juliet Nabbaale
Karen Sliwa
Emmy Okello

School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK
Alice Jackson

University of the Witwatersrand, Johannesburg, South Africa
Elena Libhaber

Department of Obstetrics and Gynaecology, School of Medicine-Makerere University, College of Health Sciences, Kampala, Uganda
Annette Nakimuli

Hampton University, Department of Chemistry and Biochemistry, USA
Graham Chakafana

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