Copyright: Clinics Cardive Publishing (Pty) Ltd. publisher
of Cardiovascular Journal of Africa.
Abstract
Objective:
We aimed to explore serum D-dimer plus fibrinogen (FIB) levels in acute myocardial infarction (AMI) for their efficiency in predicting subsequent left ventricular remodelling (LVRM).
Methods: With the period between September 2021 and January 2023 selected, 112 AMI patients hospitalised for treatment were enrolled as the subjects that were allocated to either the non-LVRM group (n = 76) or the LVRM group (n = 36) based on the findings of echocardiography.
Results: LVRM was found in 36 out of the 112 AMI patients, with an incidence rate of 32.14%, whereas the remaining 76 patients did not develop LVRM, accounting for 67.86%. The LVRM-related risk factors in AMI subjects included large infarction size, high D-dimer level, history of diabetes mellitus plus hypertension, infarction location (apex of left ventricle), and high FIB level (odds ratio > 1, p < 0.05). FIB and D-dimer levels had the areas under the plotted receiver operating characteristic curves for predicting LVRM in AMI patients of 0.764 and 0.875, respectively, showing high predictive values. FIB and D-dimer levels had a certain value in predicting LVRM in AMI patients within the threshold range of 0.04–0.95.
Conclusion: The D-dimer and FIB level measurement for AMI sufferers is conducive to the prediction of LVRM incidence.
Methods: With the period between September 2021 and January 2023 selected, 112 AMI patients hospitalised for treatment were enrolled as the subjects that were allocated to either the non-LVRM group (n = 76) or the LVRM group (n = 36) based on the findings of echocardiography.
Results: LVRM was found in 36 out of the 112 AMI patients, with an incidence rate of 32.14%, whereas the remaining 76 patients did not develop LVRM, accounting for 67.86%. The LVRM-related risk factors in AMI subjects included large infarction size, high D-dimer level, history of diabetes mellitus plus hypertension, infarction location (apex of left ventricle), and high FIB level (odds ratio > 1, p < 0.05). FIB and D-dimer levels had the areas under the plotted receiver operating characteristic curves for predicting LVRM in AMI patients of 0.764 and 0.875, respectively, showing high predictive values. FIB and D-dimer levels had a certain value in predicting LVRM in AMI patients within the threshold range of 0.04–0.95.
Conclusion: The D-dimer and FIB level measurement for AMI sufferers is conducive to the prediction of LVRM incidence.
Keywords:
acute myocardial infarction, D-Dimer, fibrinogen, left ventricular remodeling
Submitted: April 5, 2024;
Accepted: July 17, 2024;
Published: June 12, 2026
Cardiovasc J Afr 2025; 37: 239-244
Volume 37, Issue 2
Cardiovasc J Afr 2025; 37: 239-244
Volume 37, Issue 2
DOI Citation Reference: dx.doi.org/10.5830/CVJA-2026-018