Acute decompensated heart failure (ADHF) exhibits a heterogeneous diuretic response. Chloride-bicarbonate imbalance may reduce loop diuretic efficiency. The effect of admission bicarbonate levels on diuretic resistance in unselected ADHF patients remains unclear. We aimed to evaluate whether higher admission bicarbonate identifies patients at risk of early diuretic dose escalation and less...
Cardiovascular Topics
Aggressive surgical approach in diffuse coronary artery disease: coronary endarterectomy and early- to mid-term outcomes
In patients with diffuse coronary artery disease (CAD), the absence of a suitable distal target vessel for standard coronary artery bypass grafting (CABG) is the main factor limiting the success of surgical revascularisation. The aim of this study was to evaluate the surgical outcomes, complication profile, and functional recovery of a high-risk patient cohort who underwent single or multiple...
Association and causality between triglycerides and hypertension: evidence from NHANES 2007–2018 and two-sample Mendelian randomisation analysis
Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear across diverse populations. This study uses the National Health and Nutrition Examination Survey (NHANES) data to investigate this association, supporting hypertension prevention and management strategies.
Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and myocardial bridging: a cross-sectional study
Myocardial bridging (MB) is a congenital coronary anomaly that is often regarded as a benign condition but may lead to adverse clinical outcomes. Systemic metabolic and inflammatory markers have been suggested as potential indicators of MB.
Clinical outcomes and haemodynamic evolution following Perceval sutureless aortic valve implantation in high-risk aortic stenosis patients
Sutureless aortic valve replacement (AVR) has been recognised as a potential option in the management of high-risk patients, characterised by reduced procedural times and satisfactory haemodynamic results. However, mid-term results of valve-related outcomes are scarce. This study aimed to investigate clinical, echocardiographic, and valve-related outcomes of high-risk patients undergoing Perceval...
Evaluation of six-month clinical outcomes of patients with venous thromboembolism treated with apixaban, rivaroxaban, edoxaban or dabigatran
The advantages of direct oral anticoagulants (apixaban, rivaroxaban, edoxaban, dabigatran) over warfarin and low molecular weight heparin have been demonstrated in many studies in the treatment of patients with acute venous thromboembolism (VTE). However, a single-centre study comparing the effectiveness and safety of oral anticoagulants against each other has not yet been conducted.
Patient education in cardiovascular disease in Sub-Saharan Africa: the “Heart School” pilot project at IPMS/Cheikh Anta Diop University of Dakar, Senegal
To describe a patient education (PE) pilot project named “the Heart School” at Cheikh Anta Diop University of Dakar.
Pre-operative MELD-Na score as an independent predictor of post-operative mortality after valve surgery in rheumatic valvular heart disease patients
Rheumatic heart disease (RHD) poses a significant global health challenge due to its high rates of premature morbidity, mortality, and disability, particularly in low-income countries. Existing risk scoring systems for valve replacement in cardiac surgery have primarily focused on non-RHD cases, making them less applicable to RHD patients due to the distinct pathology of valvular damage. This...
Prognostic value of dobutamine stress echocardiography: A South African experience
Dobutamine stress echocardiography (DSE) is a well-established modality for the diagnosis and risk-stratification of coronary artery disease, but no prognostic data have been reported from Southern Africa.
Predictive efficiency of serum fibrinogen and D-Dimer levels for left ventricular remodelling after acute myocardial infarction
We aimed to explore serum D-dimer plus fibrinogen (FIB) levels in acute myocardial infarction (AMI) for their efficiency in predicting subsequent left ventricular remodelling (LVRM).

