Cardiovascular Journal of Africa

Cardiovascular Topics

Admission serum bicarbonate is associated with early diuretic resistance in acute decompensated heart failure

Acute decompensated heart failure (ADHF) exhibits a heterogeneous diuretic response. Chloride-bicarbonate imbalance may reduce loop diuretic efficiency. The effect of admission bicarbonate levels on diuretic resistance in unselected ADHF patients remains unclear. We aimed to evaluate whether higher admission bicarbonate identifies patients at risk of early diuretic dose escalation and less...

Aggressive surgical approach in diffuse coronary artery disease: coronary endarterectomy and early- to mid-term outcomes

In patients with diffuse coronary artery disease (CAD), the absence of a suitable distal target vessel for standard coronary artery bypass grafting (CABG) is the main factor limiting the success of surgical revascularisation. The aim of this study was to evaluate the surgical outcomes, complication profile, and functional recovery of a high-risk patient cohort who underwent single or multiple...

Association and causality between triglycerides and hypertension: evidence from NHANES 2007–2018 and two-sample Mendelian randomisation analysis

Hypertension is a major global health issue, and elevated triglyceride levels may be an independent risk factor. However, existing studies are limited, and the association remains unclear across diverse populations. This study uses the National Health and Nutrition Examination Survey (NHANES) data to investigate this association, supporting hypertension prevention and management strategies.

Clinical outcomes and haemodynamic evolution following Perceval sutureless aortic valve implantation in high-risk aortic stenosis patients

Sutureless aortic valve replacement (AVR) has been recognised as a potential option in the management of high-risk patients, characterised by reduced procedural times and satisfactory haemodynamic results. However, mid-term results of valve-related outcomes are scarce. This study aimed to investigate clinical, echocardiographic, and valve-related outcomes of high-risk patients undergoing Perceval...

Evaluation of six-month clinical outcomes of patients with venous thromboembolism treated with apixaban, rivaroxaban, edoxaban or dabigatran

The advantages of direct oral anticoagulants (apixaban, rivaroxaban, edoxaban, dabigatran) over warfarin and low molecular weight heparin have been demonstrated in many studies in the treatment of patients with acute venous thromboembolism (VTE). However, a single-centre study comparing the effectiveness and safety of oral anticoagulants against each other has not yet been conducted.

Pre-operative MELD-Na score as an independent predictor of post-operative mortality after valve surgery in rheumatic valvular heart disease patients

Rheumatic heart disease (RHD) poses a significant global health challenge due to its high rates of premature morbidity, mortality, and disability, particularly in low-income countries. Existing risk scoring systems for valve replacement in cardiac surgery have primarily focused on non-RHD cases, making them less applicable to RHD patients due to the distinct pathology of valvular damage. This...