Cardiovascular Journal of Africa

Cardiovascular Topics

Assessment of the aortic root and ascending aorta in swine using CTA

Swine are widely recognised as an essential experimental platform for evaluating prosthetic heart valves and testing novel catheter-based deployment methods. Our study aimed to establish baseline normative diameters for the aortic root and ascending aorta in swine using spiral computed tomography angiography (CTA), enhancing the success of preclinical research and device development.

Association of ACE I/D and ACE (rs4343) polymorphism with MACE development in hypertensive patients

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and ACE rs4343 polymorphism have been considered important and extensively studied for their association with cardiovascular conditions. This study investigates the association of this variant with the development of major adverse cardiovascular...

Predictive Value of the Endothelial Activation and Stress Index for No-Reflow in NSTEMI Patients Undergoing Percutaneous Coronary Intervention

The no-reflow phenomenon, defined as inadequate myocardial perfusion despite successful epicardial recanalisation, remains a major complication after PCI in NSTEMI. Endothelial dysfunction and microvascular injury are key mechanisms. The Endothelial Activation and Stress Index (EASIX), calculated as (LDH × creatinine) / platelet count, reflects systemic endothelial stress and may predict no...

Intra- and inter-rater reproducibility of the echocardiographic data of the Nigerian UPRIGHT-HTM trial participants

Echocardiography is the guideline- recommended tool for risk stratification in asymptomatic high-risk patients, but its reproducibility in sub-Saharan Africa remains largely undocumented. This study assessed the intra- and inter-rater repeatability of the risk-carrying echocardiographic traits among 42 patients enrolled in the UPRIGHT-HTM trial at three Nigerian sites.